Eczema Steroids Treatments

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OVERALL HIGHEST EFFICACY

Halobetasol

(Halobetasol propionate)

If you respond to corticosteroids and need short-term relief through a very strong steroid

Topical daily

Medium

Side Effect	Affected
Application site reactions	3%
Skin dryness
Itching at application site

$40/month

Buy Now — $40/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate
📄 Halobetasol propionate 0.05% ointment was significantly more effective than vehicle (placebo) in treating eczema. After 2 weeks of treatment, 83% of patients using halobetasol showed complete or marked improvement compared to 28% using vehicle. The medication was well-tolerated with no skin thinning reported. A review of two controlled multicenter trials comparing 0.05% halobetasol propionate ointment to its vehicle in the treatment of chronic eczematous dermatoses	Clinical Trial	Total Patients: 224	Halobetasol was significantly more effective than vehicle in treating chronic eczema

Halobetasol is generally safe and well-tolerated. Side effects are uncommon (occurring in only 2-5% of patients) and usually mild, mainly including skin dryness, itching, or burning sensations at the application site.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The cream improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111 Severity: Chronic Age: Not specified	Significant improvement in all symptoms compared to vehicle (p<0.001)

The medication is available in both cream and ointment forms, and can be effective in both adults and children. In pediatric patients, it showed excellent results with 100% success rate for eczema treatment.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates

Halobetasol propionate is highly effective at treating eczema, with success rates (defined as 'healed' or 'marked improvement') ranging from 88% to 94% in various studies. It starts working quickly, with many patients seeing improvement within 3 days of starting treatment.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The medication improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111	Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

In children with severe eczema, the combination of halobetasol propionate cream during the day and ointment at night was extremely effective, with a 100% success rate. However, careful monitoring is needed as one case of mild skin thinning was reported.

Study Summary	Study Type	Studied Population	Results

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Summary:

Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

Summary:

Halobetasol propionate 0.05% ointment was significantly more effective than vehicle (placebo) in treating eczema. After 2 weeks of treatment, 83% of patients using halobetasol showed complete or marked improvement compared to 28% using vehicle. The medication was well-tolerated with no skin thinning reported.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 224

Results:

Halobetasol was significantly more effective than vehicle in treating chronic eczema

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The cream improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Severity: Chronic

Age: Not specified

Results:

Significant improvement in all symptoms compared to vehicle (p<0.001)

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The medication improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Results:

Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

LOWEST SIDE EFFECTS

Desonide

(Desonide)

If you need a low-potency steroid treatment

Topical daily

Low

Side Effect	Affected
Cortisol suppression

$35/month

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Desonide is effective at treating atopic dermatitis, with studies showing significant improvements in symptoms like itching and inflammation. When combined with moisturizers, it shows even better results with up to 100% effectiveness compared to 60% with desonide alone.

Study Summary	Study Type	Studied Population	Results

Desonide is particularly safe for children, including infants. Studies show it rarely affects the body's natural hormone (cortisol) production, making it safer than stronger steroids like betamethasone.

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05%, a low-potency steroid, was found to be safe and effective in treating children aged 6 months to 6 years with moderate-to-severe atopic dermatitis. The treatment showed good results in improving symptoms while having minimal impact on the body's hormone system. Effect of desonide hydrogel 0.05% on the hypothalamic-pituitary-adrenal axis in pediatric subjects with moderate to severe atopic dermatitis	Clinical Trial	Total Patients: 40 Severity: moderate to severe Age: 6 months-6 years	Treatment was generally safe with minimal impact on the body's hormone system
📄 Both desonide 0.05% ointment and hydrocortisone 2.5% ointment were found to be safe for children with atopic dermatitis when used for 4 weeks. Neither medication affected the body's natural cortisol production system. Effect of desonide ointment, 0.05%, on the hypothalamic-pituitary-adrenal axis of children with atopic dermatitis	Clinical Trial		Both medications were safe for use in children and did not affect their natural cortisol production system
📄 Both desonide cream 0.1% and betamethasone cream were equally effective in treating childhood atopic dermatitis. However, desonide had less impact on the body's cortisol levels, making it potentially safer for children. [Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]	Clinical Trial	Total Patients: 29 Severity: Not specified Age: mean 13.8 months	Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05% was found to be safe and effective in treating mild to moderate atopic dermatitis in children aged 3 months to 18 years. The treatment was well-tolerated and showed significant improvements compared to the vehicle (gel without medication). Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis	Clinical Trial	Total Patients: 582	The medication showed significant improvement compared to the vehicle alone

When used with moisturizers, desonide can help prevent disease recurrence. Studies show this combination can extend the time before symptoms return to about 69 days compared to 49 days with desonide alone.

Study Summary	Study Type	Studied Population	Results

Summary:

Desonide hydrogel 0.05%, a low-potency steroid, was found to be safe and effective in treating children aged 6 months to 6 years with moderate-to-severe atopic dermatitis. The treatment showed good results in improving symptoms while having minimal impact on the body's hormone system.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 40

Severity: moderate to severe

Age: 6 months-6 years

Results:

Treatment was generally safe with minimal impact on the body's hormone system

Summary:

Both desonide 0.05% ointment and hydrocortisone 2.5% ointment were found to be safe for children with atopic dermatitis when used for 4 weeks. Neither medication affected the body's natural cortisol production system.

Study Type:

Clinical Trial

Studied Population:

Results:

Both medications were safe for use in children and did not affect their natural cortisol production system

Summary:

Both desonide cream 0.1% and betamethasone cream were equally effective in treating childhood atopic dermatitis. However, desonide had less impact on the body's cortisol levels, making it potentially safer for children.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 29

Severity: Not specified

Age: mean 13.8 months

Results:

Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Summary:

Desonide hydrogel 0.05% was found to be safe and effective in treating mild to moderate atopic dermatitis in children aged 3 months to 18 years. The treatment was well-tolerated and showed significant improvements compared to the vehicle (gel without medication).

Study Type:

Clinical Trial

Studied Population:

Total Patients: 582

Results:

The medication showed significant improvement compared to the vehicle alone

Clobetasol

(Clobetasol propionate)

If you need a super-high potency corticosteroid treatment (but should not be used for more than 2 weeks)

Topical daily

Medium

Side Effect	Affected
Morning plasma cortisol reductions	6%

$25/month

Buy Now — $25/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate cream 0.05% was tested against a vehicle (cream without active ingredient) in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

Using clobetasol propionate twice weekly as maintenance therapy can help prevent relapses in chronic eczema, with studies showing it kept 70% of patients free from relapses during the observation period

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Study Summary	Study Type	Studied Population	Results

Clobetasol propionate is highly effective at treating eczema, with success rates of over 90% in multiple studies. It typically starts working within a few days and can clear symptoms within 2-4 weeks of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate (a very strong steroid) was more effective than flupredniden acetate (a medium-strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses when used twice weekly

While generally safe for short-term use, side effects can occur in about 4% of patients. These are usually mild but can include skin thinning and temporary changes in cortisol levels. Regular monitoring by a doctor is recommended for long-term use.

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

Study Summary	Study Type	Studied Population	Results

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Summary:

Clobetasol propionate cream 0.05% was tested against a vehicle (cream without active ingredient) in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Results:

Summary:

Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%).

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Summary:

Clobetasol propionate (a very strong steroid) was more effective than flupredniden acetate (a medium-strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses when used twice weekly

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

OVERALL HIGHEST EFFICACY

Halobetasol (Halobetasol propionate)

Who is this for?:

If you respond to corticosteroids and need short-term relief through a very strong steroid

Effectiveness:

Side Effects:

Medium

Cost:

$40/month

Delivery:

Topical 1-2 daily

See Evidence

Buy Now — $40/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate
📄 Halobetasol propionate 0.05% ointment was significantly more effective than vehicle (placebo) in treating eczema. After 2 weeks of treatment, 83% of patients using halobetasol showed complete or marked improvement compared to 28% using vehicle. The medication was well-tolerated with no skin thinning reported. A review of two controlled multicenter trials comparing 0.05% halobetasol propionate ointment to its vehicle in the treatment of chronic eczematous dermatoses	Clinical Trial	Total Patients: 224	Halobetasol was significantly more effective than vehicle in treating chronic eczema

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The cream improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111 Severity: Chronic Age: Not specified	Significant improvement in all symptoms compared to vehicle (p<0.001)

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The medication improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111	Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

Study Summary	Study Type	Studied Population	Results

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 224

Results:

Halobetasol was significantly more effective than vehicle in treating chronic eczema

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Severity: Chronic

Age: Not specified

Results:

Significant improvement in all symptoms compared to vehicle (p<0.001)

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Results:

Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

LOWEST SIDE EFFECTS

Desonide (Desonide)

Who is this for?:

If you need a low-potency steroid treatment

Effectiveness:

Side Effects:

Low

Cost:

$35/month

Delivery:

Topical daily

See Evidence

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05%, a low-potency steroid, was found to be safe and effective in treating children aged 6 months to 6 years with moderate-to-severe atopic dermatitis. The treatment showed good results in improving symptoms while having minimal impact on the body's hormone system. Effect of desonide hydrogel 0.05% on the hypothalamic-pituitary-adrenal axis in pediatric subjects with moderate to severe atopic dermatitis	Clinical Trial	Total Patients: 40 Severity: moderate to severe Age: 6 months-6 years	Treatment was generally safe with minimal impact on the body's hormone system
📄 Both desonide 0.05% ointment and hydrocortisone 2.5% ointment were found to be safe for children with atopic dermatitis when used for 4 weeks. Neither medication affected the body's natural cortisol production system. Effect of desonide ointment, 0.05%, on the hypothalamic-pituitary-adrenal axis of children with atopic dermatitis	Clinical Trial		Both medications were safe for use in children and did not affect their natural cortisol production system
📄 Both desonide cream 0.1% and betamethasone cream were equally effective in treating childhood atopic dermatitis. However, desonide had less impact on the body's cortisol levels, making it potentially safer for children. [Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]	Clinical Trial	Total Patients: 29 Severity: Not specified Age: mean 13.8 months	Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05% was found to be safe and effective in treating mild to moderate atopic dermatitis in children aged 3 months to 18 years. The treatment was well-tolerated and showed significant improvements compared to the vehicle (gel without medication). Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis	Clinical Trial	Total Patients: 582	The medication showed significant improvement compared to the vehicle alone

Study Summary	Study Type	Studied Population	Results

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 40

Severity: moderate to severe

Age: 6 months-6 years

Results:

Treatment was generally safe with minimal impact on the body's hormone system

Summary:

Study Type:

Clinical Trial

Studied Population:

Results:

Both medications were safe for use in children and did not affect their natural cortisol production system

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 29

Severity: Not specified

Age: mean 13.8 months

Results:

Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 582

Results:

The medication showed significant improvement compared to the vehicle alone

Clobetasol (Clobetasol propionate)

Who is this for?:

If you need a super-high potency corticosteroid treatment (but should not be used for more than 2 weeks)

Effectiveness:

Side Effects:

Medium

Cost:

$25/month

Delivery:

Topical 2 daily

See Evidence

Buy Now — $25/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate cream 0.05% was tested against a vehicle (cream without active ingredient) in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Study Summary	Study Type	Studied Population	Results

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate (a very strong steroid) was more effective than flupredniden acetate (a medium-strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses when used twice weekly

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

Study Summary	Study Type	Studied Population	Results

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Results:

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses when used twice weekly

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

All Steroids Treatments

Treatment

Who is this for?

Delivery

Effectiveness

Side Effects

Estimated Cost

OVERALL HIGHEST EFFICACY

Halobetasol

(Halobetasol propionate)

If you respond to corticosteroids and need short-term relief through a very strong steroid

Topical daily

Medium

Side Effect	Affected
Application site reactions	3%
Skin dryness
Itching at application site

$40/month

Buy Now — $40/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate
📄 Halobetasol propionate 0.05% ointment was significantly more effective than vehicle (placebo) in treating eczema. After 2 weeks of treatment, 83% of patients using halobetasol showed complete or marked improvement compared to 28% using vehicle. The medication was well-tolerated with no skin thinning reported. A review of two controlled multicenter trials comparing 0.05% halobetasol propionate ointment to its vehicle in the treatment of chronic eczematous dermatoses	Clinical Trial	Total Patients: 224	Halobetasol was significantly more effective than vehicle in treating chronic eczema

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The cream improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111 Severity: Chronic Age: Not specified	Significant improvement in all symptoms compared to vehicle (p<0.001)

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The medication improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111	Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

Study Summary	Study Type	Studied Population	Results

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 224

Results:

Halobetasol was significantly more effective than vehicle in treating chronic eczema

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Severity: Chronic

Age: Not specified

Results:

Significant improvement in all symptoms compared to vehicle (p<0.001)

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Results:

Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

LOWEST SIDE EFFECTS

Desonide

(Desonide)

If you need a low-potency steroid treatment

Topical daily

Low

Side Effect	Affected
Cortisol suppression

$35/month

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05%, a low-potency steroid, was found to be safe and effective in treating children aged 6 months to 6 years with moderate-to-severe atopic dermatitis. The treatment showed good results in improving symptoms while having minimal impact on the body's hormone system. Effect of desonide hydrogel 0.05% on the hypothalamic-pituitary-adrenal axis in pediatric subjects with moderate to severe atopic dermatitis	Clinical Trial	Total Patients: 40 Severity: moderate to severe Age: 6 months-6 years	Treatment was generally safe with minimal impact on the body's hormone system
📄 Both desonide 0.05% ointment and hydrocortisone 2.5% ointment were found to be safe for children with atopic dermatitis when used for 4 weeks. Neither medication affected the body's natural cortisol production system. Effect of desonide ointment, 0.05%, on the hypothalamic-pituitary-adrenal axis of children with atopic dermatitis	Clinical Trial		Both medications were safe for use in children and did not affect their natural cortisol production system
📄 Both desonide cream 0.1% and betamethasone cream were equally effective in treating childhood atopic dermatitis. However, desonide had less impact on the body's cortisol levels, making it potentially safer for children. [Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]	Clinical Trial	Total Patients: 29 Severity: Not specified Age: mean 13.8 months	Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05% was found to be safe and effective in treating mild to moderate atopic dermatitis in children aged 3 months to 18 years. The treatment was well-tolerated and showed significant improvements compared to the vehicle (gel without medication). Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis	Clinical Trial	Total Patients: 582	The medication showed significant improvement compared to the vehicle alone

Study Summary	Study Type	Studied Population	Results

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 40

Severity: moderate to severe

Age: 6 months-6 years

Results:

Treatment was generally safe with minimal impact on the body's hormone system

Summary:

Study Type:

Clinical Trial

Studied Population:

Results:

Both medications were safe for use in children and did not affect their natural cortisol production system

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 29

Severity: Not specified

Age: mean 13.8 months

Results:

Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 582

Results:

The medication showed significant improvement compared to the vehicle alone

Clobetasol

(Clobetasol propionate)

If you need a super-high potency corticosteroid treatment (but should not be used for more than 2 weeks)

Topical daily

Medium

Side Effect	Affected
Morning plasma cortisol reductions	6%

$25/month

Buy Now — $25/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate cream 0.05% was tested against a vehicle (cream without active ingredient) in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Study Summary	Study Type	Studied Population	Results

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate (a very strong steroid) was more effective than flupredniden acetate (a medium-strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses when used twice weekly

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

Study Summary	Study Type	Studied Population	Results

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Results:

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses when used twice weekly

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

Betamethasone

(Betamethasone)

If you are 13 or older and responds to corticosteroids

If you respond to corticosteroids

Topical daily

Medium

Side Effect	Affected
Skin thinning (atrophy)

$35/month

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Betamethasone is effective at reducing inflammation and symptoms of eczema, with studies showing 76-94% of patients experiencing significant improvement within 2-3 weeks of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Both betamethasone and tacrolimus treatments effectively reduced eczema severity and inflammation. Betamethasone was better at reducing inflammation, while tacrolimus was better at improving skin hydration. Skin and systemic inflammation in adults with atopic dermatitis before and after whole-body topical betamethasone 17-valerate 0.1% or tacrolimus 0.1% treatment: A randomized controlled study	Randomized Controlled Trial	Total Patients: 36 Severity: moderate Age: 18+	Both treatments effectively reduced disease severity

While betamethasone provides quick relief, long-term use may damage the skin barrier and cause skin thinning. It's better suited for short-term treatment of severe flares rather than long-term maintenance therapy.

Study Summary	Study Type	Studied Population	Results
📄 Both betamethasone and pimecrolimus improved skin barrier function and reduced symptoms in atopic dermatitis. While betamethasone was better at reducing symptoms, it caused skin thinning, making pimecrolimus potentially better for long-term use. Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis	Randomized Controlled Trial	Total Patients: 15 Severity: not available Age: not available	Betamethasone was more effective at reducing clinical symptoms
📄 Betamethasone was more effective at reducing inflammation compared to pimecrolimus in atopic dermatitis skin samples. However, betamethasone may impair skin barrier repair, while pimecrolimus helps maintain it, suggesting pimecrolimus might be better for long-term treatment. Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis	Clinical Trial	Severity: not available Age: not available
📄 In people with controlled atopic dermatitis, betamethasone cream damaged the skin barrier after 4 weeks of use, while tacrolimus ointment improved skin barrier function. Tacrolimus was better at maintaining skin hydration and natural moisturizing factors. The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis	Randomized Controlled Trial	Total Patients: 20	Tacrolimus was superior to betamethasone for maintaining skin barrier health

When combined with antibacterial agents like fusidic acid, betamethasone is more effective at treating infected eczema, eliminating 67% of bacteria compared to 51% with betamethasone alone.

Study Summary	Study Type	Studied Population	Results
📄 A new cream containing fusidic acid and betamethasone (Fucicort Lipid cream) was found to be as effective as the existing cream formulation in treating infected atopic dermatitis. Both creams reduced severity scores by about 83% and cleared bacterial infection in about 90% of patients after 2 weeks of treatment. An efficient new formulation of fusidic acid and betamethasone 17-valerate (fucicort lipid cream) for treatment of clinically infected atopic dermatitis	Randomized Controlled Trial	Total Patients: 629 Severity: Not specified Age: Not specified	Both Fucicort formulations showed similar effectiveness, significantly better than vehicle

Alternative treatments like tacrolimus or pimecrolimus may be better for long-term use as they improve skin barrier function without causing the skin thinning associated with betamethasone.

Study Summary	Study Type	Studied Population	Results
📄 Both tacrolimus and betamethasone improved skin barrier function during treatment. However, after stopping treatment, the benefits lasted longer with tacrolimus while the improvement from betamethasone partially wore off. Comparative effect of tacrolimus and betamethasone valerate on the passive sustainable hydration of the stratum corneum in atopic dermatitis	Randomized Controlled Trial	Total Patients: 21 Severity: moderate Age: not available	Both treatments improved skin barrier function, but tacrolimus benefits lasted longer after stopping treatment
📄 In people with controlled atopic dermatitis, betamethasone cream damaged the skin barrier after 4 weeks of use, while tacrolimus ointment improved skin barrier function. Tacrolimus was better at maintaining skin hydration and natural moisturizing factors. The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis	Randomized Controlled Trial	Total Patients: 20	Tacrolimus was superior to betamethasone for maintaining skin barrier health
📄 Both betamethasone and pimecrolimus improved skin barrier function and reduced symptoms in atopic dermatitis. While betamethasone was better at reducing symptoms, it caused skin thinning, making pimecrolimus potentially better for long-term use. Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis	Randomized Controlled Trial	Total Patients: 15 Severity: not available Age: not available	Betamethasone was more effective at reducing clinical symptoms

Betamethasone is effective at reducing inflammation and symptoms of eczema, with studies showing 76-94% of patients experiencing significant improvement within 2-3 weeks of treatment.

Summary:

Both betamethasone and tacrolimus treatments effectively reduced eczema severity and inflammation. Betamethasone was better at reducing inflammation, while tacrolimus was better at improving skin hydration.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 36

Severity: moderate

Age: 18+

Results:

Both treatments effectively reduced disease severity

Summary:

Both betamethasone and pimecrolimus improved skin barrier function and reduced symptoms in atopic dermatitis. While betamethasone was better at reducing symptoms, it caused skin thinning, making pimecrolimus potentially better for long-term use.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 15

Severity: not available

Age: not available

Results:

Betamethasone was more effective at reducing clinical symptoms

Summary:

Betamethasone was more effective at reducing inflammation compared to pimecrolimus in atopic dermatitis skin samples. However, betamethasone may impair skin barrier repair, while pimecrolimus helps maintain it, suggesting pimecrolimus might be better for long-term treatment.

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: not available

Results:

Summary:

In people with controlled atopic dermatitis, betamethasone cream damaged the skin barrier after 4 weeks of use, while tacrolimus ointment improved skin barrier function. Tacrolimus was better at maintaining skin hydration and natural moisturizing factors.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 20

Results:

Tacrolimus was superior to betamethasone for maintaining skin barrier health

When combined with antibacterial agents like fusidic acid, betamethasone is more effective at treating infected eczema, eliminating 67% of bacteria compared to 51% with betamethasone alone.

Summary:

A new cream containing fusidic acid and betamethasone (Fucicort Lipid cream) was found to be as effective as the existing cream formulation in treating infected atopic dermatitis. Both creams reduced severity scores by about 83% and cleared bacterial infection in about 90% of patients after 2 weeks of treatment.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 629

Severity: Not specified

Age: Not specified

Results:

Both Fucicort formulations showed similar effectiveness, significantly better than vehicle

Alternative treatments like tacrolimus or pimecrolimus may be better for long-term use as they improve skin barrier function without causing the skin thinning associated with betamethasone.

Summary:

Both tacrolimus and betamethasone improved skin barrier function during treatment. However, after stopping treatment, the benefits lasted longer with tacrolimus while the improvement from betamethasone partially wore off.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 21

Severity: moderate

Age: not available

Results:

Both treatments improved skin barrier function, but tacrolimus benefits lasted longer after stopping treatment

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 20

Results:

Tacrolimus was superior to betamethasone for maintaining skin barrier health

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 15

Severity: not available

Age: not available

Results:

Betamethasone was more effective at reducing clinical symptoms

Mometasone

(Mometasone furoate)

If you respond to corticosteroids and need short-term relief through a very strong steroid

If you respond to corticosteroids

Topical daily

Medium

$35/month

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Mometasone furoate cream is effective in treating atopic dermatitis, with success rates ranging from 80% to 90%. It can be used once daily, making it convenient for patients.

Study Summary	Study Type	Studied Population	Results
📄 Using mometasone cream together with an Alginate Skin Repair Mask was more effective than using mometasone cream alone for treating atopic dermatitis. The combination treatment showed better results with 97.5% effectiveness compared to 80% for cream alone, and had fewer side effects and disease recurrences. Efficacy of Mometasone Furoate Cream Sodium Alginate Skin Repair Mask in Atopic Dermatitis Treatment	Randomized Controlled Trial	Total Patients: 80 Severity: Not specified Age: 20-47 years	Combination therapy resulted in significantly lower SCORAD scores

The treatment is generally safe, especially in children. In studies, it showed minimal side effects and didn't affect children's growth when used as directed. Morning cortisol levels remained normal in most cases, indicating minimal impact on the body's hormone system.

Study Summary	Study Type	Studied Population	Results
📄 In children with mild to moderate eczema, neither mometasone furoate 0.1% nor tacrolimus 0.1% affected their short-term growth rates. This suggests these treatments are safe to use in children without concerns about growth suppression. Short-term growth in children with eczema during treatment with topical mometasone furoate and tacrolimus	Randomized Controlled Trial	Total Patients: 20 Severity: mild to moderate Age: 5-12 years	No statistically significant effect on growth rate was observed with either treatment

Long-term intermittent use (2-3 times per week) can help prevent disease recurrence. In one study, 83% of patients using it three times per week had no recurrences, compared to only 26% of those who stopped treatment completely.

Study Summary	Study Type	Studied Population	Results
📄 Long-term intermittent treatment with mometasone furoate cream was effective for chronic hand eczema. Using the cream 3 times per week was more effective than using it 2 times per week or stopping treatment, with 83% of patients having no recurrence when using it 3 times weekly. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate	Clinical Trial	Total Patients: 120 Severity: chronic hand eczema Age: not available	Three-times-weekly maintenance therapy was most effective at preventing recurrence

The effectiveness of mometasone can be enhanced when combined with other treatments. For example, using it with wet wrap dressings or skin repair masks showed better results than using mometasone alone.

Study Summary	Study Type	Studied Population	Results
📄 Using mometasone cream together with an Alginate Skin Repair Mask was more effective than using mometasone cream alone for treating atopic dermatitis. The combination treatment showed better results with 97.5% effectiveness compared to 80% for cream alone, and had fewer side effects and disease recurrences. Efficacy of Mometasone Furoate Cream Sodium Alginate Skin Repair Mask in Atopic Dermatitis Treatment	Randomized Controlled Trial	Total Patients: 80 Severity: Not specified Age: 20-47 years	Combination therapy resulted in significantly lower SCORAD scores
📄 Both mometasone and fluticasone ointments were effective in treating moderate to severe atopic dermatitis in children. Using wet wrap dressings after 2 weeks of treatment provided additional improvement in symptoms. The effectiveness of wet wrap dressings using 0.1% mometasone furoate and 0.005% fluticasone proprionate ointments in the treatment of moderate to severe atopic dermatitis in children	Clinical Trial	Total Patients: 40 Severity: moderate to severe Age: children (age range not specified)	Both treatments were effective, with additional benefits when wet wraps were added

Mometasone furoate cream is effective in treating atopic dermatitis, with success rates ranging from 80% to 90%. It can be used once daily, making it convenient for patients.

Summary:

Using mometasone cream together with an Alginate Skin Repair Mask was more effective than using mometasone cream alone for treating atopic dermatitis. The combination treatment showed better results with 97.5% effectiveness compared to 80% for cream alone, and had fewer side effects and disease recurrences.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 80

Severity: Not specified

Age: 20-47 years

Results:

Combination therapy resulted in significantly lower SCORAD scores

Summary:

In children with mild to moderate eczema, neither mometasone furoate 0.1% nor tacrolimus 0.1% affected their short-term growth rates. This suggests these treatments are safe to use in children without concerns about growth suppression.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 20

Severity: mild to moderate

Age: 5-12 years

Results:

No statistically significant effect on growth rate was observed with either treatment

Summary:

Long-term intermittent treatment with mometasone furoate cream was effective for chronic hand eczema. Using the cream 3 times per week was more effective than using it 2 times per week or stopping treatment, with 83% of patients having no recurrence when using it 3 times weekly.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Severity: chronic hand eczema

Age: not available

Results:

Three-times-weekly maintenance therapy was most effective at preventing recurrence

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 80

Severity: Not specified

Age: 20-47 years

Results:

Combination therapy resulted in significantly lower SCORAD scores

Summary:

Both mometasone and fluticasone ointments were effective in treating moderate to severe atopic dermatitis in children. Using wet wrap dressings after 2 weeks of treatment provided additional improvement in symptoms.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 40

Severity: moderate to severe

Age: children (age range not specified)

Results:

Both treatments were effective, with additional benefits when wet wraps were added

Triamcinolone acetonide

(Triamcinolone acetonide)

If you are looking for short-term relief through a potent topical corticosteroid

Topical daily

Medium

Side Effect	Affected
Local reactions
skin irritation

$30/month

Buy Now — $30/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Triamcinolone acetonide is effective at reducing inflammation and improving symptoms of atopic dermatitis, with significant improvements seen within 2-4 weeks of treatment

Study Summary	Study Type	Studied Population	Results
📄 A cream containing triamcinolone acetonide combined with laurocapram was more effective at treating atopic dermatitis compared to triamcinolone acetonide alone or vehicle control. The combination improved redness, skin thickness, and itching with minimal side effects. Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis	Clinical Trial	Total Patients: 150	TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control
📄 Adding tetracycline to triamcinolone acetonide (a steroid) cream did not improve eczema symptoms more than using triamcinolone acetonide alone. However, the combination did reduce bacterial skin infection better than the steroid alone. A randomized, double-blind study to assess the efficacy of addition of tetracycline to triamcinolone acetonide in the treatment of moderate to severe atopic dermatitis	Randomized Controlled Trial	Total Patients: 44

The medication is equally effective whether used as a cream or ointment with wet wraps, so patients can choose the form they prefer. While ointments were harder to apply, patients often preferred them for future use

Study Summary	Study Type	Studied Population	Results
📄 Both cream and ointment forms of triamcinolone acetonide were equally effective when used with wet wraps for treating atopic dermatitis in children. While patients found the ointment more difficult to apply, they preferred it for future treatments. Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: A randomized split-body control study	Randomized Controlled Trial	Total Patients: 39 Severity: not available Age: pediatric	No significant difference in effectiveness between cream and ointment formulations

Triamcinolone acetonide appears to be safe, with only minor local reactions reported in a small number of patients (around 4-6% of users)

Study Summary	Study Type	Studied Population	Results
📄 A cream containing triamcinolone acetonide combined with laurocapram was more effective at treating atopic dermatitis compared to triamcinolone acetonide alone or vehicle control. The combination improved redness, skin thickness, and itching with minimal side effects. Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis	Clinical Trial	Total Patients: 150	TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control

Surprisingly, even very low doses of triamcinolone acetonide (40 times lower than typical commercial products) can be effective at reducing inflammation in mild to moderate atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 A low-dose steroid cream (triamcinolone acetonide) at 25 microg/g concentration was effective in treating mild to moderate atopic dermatitis. The low-dose steroid showed significant improvement compared to the cream without steroid after just one week of treatment. Low-dose triamcinolone acetonide in the phytocosmetic lichtena reduces inflammation in mild to moderate atopic dermatitis	Randomized Controlled Trial	Total Patients: 14	Low-dose steroid cream showed significant improvement in SCORAD scores starting from week 1, while the plain cream showed no improvement

Triamcinolone acetonide is effective at reducing inflammation and improving symptoms of atopic dermatitis, with significant improvements seen within 2-4 weeks of treatment

Summary:

A cream containing triamcinolone acetonide combined with laurocapram was more effective at treating atopic dermatitis compared to triamcinolone acetonide alone or vehicle control. The combination improved redness, skin thickness, and itching with minimal side effects.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 150

Results:

TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control

Summary:

Adding tetracycline to triamcinolone acetonide (a steroid) cream did not improve eczema symptoms more than using triamcinolone acetonide alone. However, the combination did reduce bacterial skin infection better than the steroid alone.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 44

Results:

Summary:

Both cream and ointment forms of triamcinolone acetonide were equally effective when used with wet wraps for treating atopic dermatitis in children. While patients found the ointment more difficult to apply, they preferred it for future treatments.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 39

Severity: not available

Age: pediatric

Results:

No significant difference in effectiveness between cream and ointment formulations

Triamcinolone acetonide appears to be safe, with only minor local reactions reported in a small number of patients (around 4-6% of users)

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 150

Results:

TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control

Surprisingly, even very low doses of triamcinolone acetonide (40 times lower than typical commercial products) can be effective at reducing inflammation in mild to moderate atopic dermatitis

Summary:

A low-dose steroid cream (triamcinolone acetonide) at 25 microg/g concentration was effective in treating mild to moderate atopic dermatitis. The low-dose steroid showed significant improvement compared to the cream without steroid after just one week of treatment.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 14

Results:

Low-dose steroid cream showed significant improvement in SCORAD scores starting from week 1, while the plain cream showed no improvement

Hydrocortisone cream

(Hydrocortisone)

For temporary relief of itch and rashes

Topical daily

Medium

Side Effect	Affected
Adrenal suppression	8%
Burning sensation	2%
Cutaneous reactions
Skin burning

$25/month

Buy Hydrocortisone cream

No prescription needed

KEY TAKEAWAYS

Topical corticosteroids are effective as a first-line treatment for atopic dermatitis, with studies showing significant improvement in symptoms within weeks of proper use

Study Summary	Study Type	Studied Population	Results
📄 A spray form of the steroid desoximetasone was tested in adults with atopic dermatitis. The spray significantly reduced itch and improved symptoms within 1 week, and these improvements lasted throughout the 4-week study. No side effects were reported. Efficacy and Safety of Desoximetasone 0.25% Spray in Adult Atopic Dermatitis Subjects: Pilot Study. (2017)	Clinical Trial	Severity: not available Age: 18+	Skin appearance improved within 1 week and stayed better for 4 weeks
📄 Using a strong steroid cream (fluticasone) worked better than a mild steroid cream (hydrocortisone) for treating moderate eczema flare-ups in children. Children using the stronger steroid had better symptom improvement and quality of life over 24 weeks. Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial (2024)	Randomized Controlled Trial	Total Patients: 32 Severity: moderate Age: 3 months-17 years	Strong steroid showed significantly better symptom control throughout the study period
📄 The study compared two ways of applying steroid cream in children with eczema - either on wet skin after a bath (soak and smear) or on dry skin. Both methods worked equally well, improving eczema by about 80-85%. A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD). (2016)	Randomized Controlled Trial	Total Patients: 45 Severity: not available Age: children (specific range not available)	Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Potent (stronger) topical corticosteroids may be more effective than mild ones for moderate flare-ups, showing better symptom improvement and quality of life scores over 24 weeks

Study Summary	Study Type	Studied Population	Results
📄 Using a strong steroid cream (fluticasone) worked better than a mild steroid cream (hydrocortisone) for treating moderate eczema flare-ups in children. Children using the stronger steroid had better symptom improvement and quality of life over 24 weeks. Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial (2024)	Randomized Controlled Trial	Total Patients: 32 Severity: moderate Age: 3 months-17 years	Strong steroid showed significantly better symptom control throughout the study period

The method of applying topical steroids (whether to wet or dry skin) does not significantly affect treatment outcomes, suggesting flexibility in application methods

Study Summary	Study Type	Studied Population	Results
📄 The study compared two ways of applying steroid cream in children with eczema - either on wet skin after a bath (soak and smear) or on dry skin. Both methods worked equally well, improving eczema by about 80-85%. A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD). (2016)	Randomized Controlled Trial	Total Patients: 45 Severity: not available Age: children (specific range not available)	Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Topical corticosteroids are effective as a first-line treatment for atopic dermatitis, with studies showing significant improvement in symptoms within weeks of proper use

Summary:

A spray form of the steroid desoximetasone was tested in adults with atopic dermatitis. The spray significantly reduced itch and improved symptoms within 1 week, and these improvements lasted throughout the 4-week study. No side effects were reported.

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: 18+

Results:

Skin appearance improved within 1 week and stayed better for 4 weeks

Summary:

Using a strong steroid cream (fluticasone) worked better than a mild steroid cream (hydrocortisone) for treating moderate eczema flare-ups in children. Children using the stronger steroid had better symptom improvement and quality of life over 24 weeks.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 32

Severity: moderate

Age: 3 months-17 years

Results:

Strong steroid showed significantly better symptom control throughout the study period

Summary:

The study compared two ways of applying steroid cream in children with eczema - either on wet skin after a bath (soak and smear) or on dry skin. Both methods worked equally well, improving eczema by about 80-85%.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 45

Severity: not available

Age: children (specific range not available)

Results:

Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Potent (stronger) topical corticosteroids may be more effective than mild ones for moderate flare-ups, showing better symptom improvement and quality of life scores over 24 weeks

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 32

Severity: moderate

Age: 3 months-17 years

Results:

Strong steroid showed significantly better symptom control throughout the study period

The method of applying topical steroids (whether to wet or dry skin) does not significantly affect treatment outcomes, suggesting flexibility in application methods

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 45

Severity: not available

Age: children (specific range not available)

Results:

Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Fluocinonide

(Fluocinonide)

If you need a strong topical steroid

Topical daily

Medium

Side Effect	Affected
mild drug-related effects	12%
burning sensation	4%

$30/month

Discuss with a Dermatologist

KEY TAKEAWAYS

Fluocinonide cream is effective at treating atopic dermatitis, with studies showing significant improvement in symptoms like itching and rash severity within 2 weeks of treatment. In one study, itching decreased by 79% and overall severity decreased by 76%.

Study Summary	Study Type	Studied Population	Results
📄 A 3-day treatment with fluocinonide cream showed high patient adherence (100%) and significant improvement in eczema symptoms. By day 14, patients experienced 79% reduction in itching and 76% improvement in eczema severity, with more than half of patients achieving clear or almost clear skin. Improvement in treatment adherence with a 3-day course of fluocinonide cream 0.1% for atopic dermatitis	Clinical Trial	Total Patients: 20 Severity: mild to severe Age: not available	Significant reduction in itching after treatment
📄 A two-week treatment with fluocinonide 0.1% cream improved skin barrier function and reduced symptoms in patients with moderate-to-severe atopic dermatitis. 28% of patients achieved clear or almost clear skin after treatment. Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis	Clinical Trial	Total Patients: 25	Significant improvement in eczema severity

Once-daily application of fluocinonide appears to be as effective as twice-daily use, with a lower risk of side effects. The medication is generally well-tolerated, though some patients may experience mild burning sensation during the first few days of use.

Study Summary	Study Type	Studied Population	Results
📄 Fluocinonide cream 0.1% was found to be safe and effective when used once daily in children with moderate to severe atopic dermatitis. Over 90% of patients showed improvement in their condition, and applying it once daily was as effective as twice daily with lower risk of side effects. An open-label adrenal suppression study of 0.1% fluocinonide cream in pediatric patients with atopic dermatitis	Randomized Controlled Trial		Treatment was highly effective with both once-daily and twice-daily application
📄 A two-week treatment with fluocinonide 0.1% cream improved skin barrier function and reduced symptoms in patients with moderate-to-severe atopic dermatitis. 28% of patients achieved clear or almost clear skin after treatment. Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis	Clinical Trial	Total Patients: 25	Significant improvement in eczema severity

Short-term use (2-3 weeks) of fluocinonide actually helps improve the skin barrier function in people with atopic dermatitis, though long-term use should be avoided as it can cause skin thinning.

Study Summary	Study Type	Studied Population	Results
📄 A two-week treatment with fluocinonide 0.1% cream improved skin barrier function and reduced symptoms in patients with moderate-to-severe atopic dermatitis. 28% of patients achieved clear or almost clear skin after treatment. Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis	Clinical Trial	Total Patients: 25	Significant improvement in eczema severity

Studies show fluocinonide is more effective than some other topical steroids like halcinonide for treating atopic dermatitis.

Study Summary	Study Type	Studied Population	Results

Summary:

A 3-day treatment with fluocinonide cream showed high patient adherence (100%) and significant improvement in eczema symptoms. By day 14, patients experienced 79% reduction in itching and 76% improvement in eczema severity, with more than half of patients achieving clear or almost clear skin.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 20

Severity: mild to severe

Age: not available

Results:

Significant reduction in itching after treatment

Summary:

A two-week treatment with fluocinonide 0.1% cream improved skin barrier function and reduced symptoms in patients with moderate-to-severe atopic dermatitis. 28% of patients achieved clear or almost clear skin after treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 25

Results:

Significant improvement in eczema severity

Summary:

Fluocinonide cream 0.1% was found to be safe and effective when used once daily in children with moderate to severe atopic dermatitis. Over 90% of patients showed improvement in their condition, and applying it once daily was as effective as twice daily with lower risk of side effects.

Study Type:

Randomized Controlled Trial

Studied Population:

Results:

Treatment was highly effective with both once-daily and twice-daily application

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 25

Results:

Significant improvement in eczema severity

Short-term use (2-3 weeks) of fluocinonide actually helps improve the skin barrier function in people with atopic dermatitis, though long-term use should be avoided as it can cause skin thinning.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 25

Results:

Significant improvement in eczema severity

Studies show fluocinonide is more effective than some other topical steroids like halcinonide for treating atopic dermatitis.

Prednisone

(Prednisone)

If you're open to steroids and growth suppression is not a concern

If you're open to steroids and topical treatments haven't worked for you

Oral daily

Medium

Side Effect	Affected
Sodium retention	9999%
Congestive heart failure	9999%
Muscle weakness	9999%
Osteoporosis	9999%

$25/month

Buy Now — $25/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Oral prednisolone is not recommended as a first-line treatment for severe adult eczema. In a direct comparison study, ciclosporin was found to be significantly more effective than prednisolone for treating severe eczema in adults.

Study Summary	Study Type	Studied Population	Results
📄 Ciclosporin was found to be more effective than prednisolone for treating severe eczema in adults. Only 1 out of 21 patients on prednisolone achieved stable improvement compared to 6 out of 17 patients on ciclosporin. The study was stopped early due to many patients on prednisolone experiencing significant worsening of their eczema. Prednisolone vs. ciclosporin for severe adult eczema. An investigator-initiated double-blind placebo-controlled multicentre trial	Randomized Controlled Trial	Total Patients: 38	Ciclosporin was significantly more effective than prednisolone

Topical forms of prednisolone (like methylprednisolone aceponate) can be effective for treating eczema flares and preventing relapses. When used twice weekly along with moisturizers, it reduced the risk of flares by 87% over 16 weeks.

Study Summary	Study Type	Studied Population	Results
📄 Using methylprednisolone aceponate cream twice weekly along with moisturizer was more effective at preventing eczema flares than using moisturizer alone. After 16 weeks, 87.1% of patients using the steroid cream remained free from flares compared to 65.8% using just moisturizer. Reduction of relapses of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient: a multicentre, randomized, double-blind, controlled study	Randomized Controlled Trial	Total Patients: 249	Patients using the steroid cream were 3.5 times less likely to experience a relapse

Topical methylprednisolone aceponate provides fast itch relief, with patients experiencing significant reduction in itching within 1-2 days of starting treatment.

Study Summary	Study Type	Studied Population	Results
📄 In a study of experimental eczema caused by nickel allergy, methylprednisolone aceponate (a topical corticosteroid) provided fast itch relief. On average, significant itch relief was achieved within 1 day of treatment. Fast itch relief in an experimental model for methylprednisolone aceponate topical corticosteroid activity, based on allergic contact eczema to nickel sulphate	Clinical Trial	Total Patients: 16 Severity: not available Age: not available	Treatment provided fast and effective itch relief

In children and adolescents with severe eczema, topical methylprednisolone aceponate 0.1% was found to be as effective as tacrolimus 0.03% for overall improvement, and better for reducing itch and improving sleep. It also had fewer side effects and lower cost.

Study Summary	Study Type	Studied Population	Results
📄 Both methylprednisolone aceponate 0.1% ointment and tacrolimus 0.03% ointment were effective in treating severe atopic dermatitis in children and adolescents. Methylprednisolone showed better results for reducing itch and improving sleep, and was more cost-effective. Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis	Randomized Controlled Trial	Total Patients: 265 Severity: severe to very severe Age: children and adolescents	Both treatments were equally effective in achieving clear or almost clear skin

Summary:

Ciclosporin was found to be more effective than prednisolone for treating severe eczema in adults. Only 1 out of 21 patients on prednisolone achieved stable improvement compared to 6 out of 17 patients on ciclosporin. The study was stopped early due to many patients on prednisolone experiencing significant worsening of their eczema.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 38

Results:

Ciclosporin was significantly more effective than prednisolone

Summary:

Using methylprednisolone aceponate cream twice weekly along with moisturizer was more effective at preventing eczema flares than using moisturizer alone. After 16 weeks, 87.1% of patients using the steroid cream remained free from flares compared to 65.8% using just moisturizer.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 249

Results:

Patients using the steroid cream were 3.5 times less likely to experience a relapse

Topical methylprednisolone aceponate provides fast itch relief, with patients experiencing significant reduction in itching within 1-2 days of starting treatment.

Summary:

In a study of experimental eczema caused by nickel allergy, methylprednisolone aceponate (a topical corticosteroid) provided fast itch relief. On average, significant itch relief was achieved within 1 day of treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 16

Severity: not available

Age: not available

Results:

Treatment provided fast and effective itch relief

Summary:

Both methylprednisolone aceponate 0.1% ointment and tacrolimus 0.03% ointment were effective in treating severe atopic dermatitis in children and adolescents. Methylprednisolone showed better results for reducing itch and improving sleep, and was more cost-effective.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 265

Severity: severe to very severe

Age: children and adolescents

Results:

Both treatments were equally effective in achieving clear or almost clear skin

OVERALL HIGHEST EFFICACY

Halobetasol (Halobetasol propionate)

Who is this for?:

If you respond to corticosteroids and need short-term relief through a very strong steroid

Effectiveness:

Side Effects:

Medium

Cost:

$40/month

Delivery:

Topical 1-2 daily

See Evidence

Buy Now — $40/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate
📄 Halobetasol propionate 0.05% ointment was significantly more effective than vehicle (placebo) in treating eczema. After 2 weeks of treatment, 83% of patients using halobetasol showed complete or marked improvement compared to 28% using vehicle. The medication was well-tolerated with no skin thinning reported. A review of two controlled multicenter trials comparing 0.05% halobetasol propionate ointment to its vehicle in the treatment of chronic eczematous dermatoses	Clinical Trial	Total Patients: 224	Halobetasol was significantly more effective than vehicle in treating chronic eczema

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The cream improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111 Severity: Chronic Age: Not specified	Significant improvement in all symptoms compared to vehicle (p<0.001)

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-93% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not specified	All three treatments showed similar high success rates

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate cream 0.05% was significantly more effective than placebo in treating atopic dermatitis symptoms when applied twice daily for 14 days. The medication improved itching, redness, scaling, and thickened skin, with benefits seen within 7 days of treatment. Double-blind bilateral paired comparison of 0.05% halobetasol propionate cream and its vehicle in patients with chronic atopic dermatitis and other eczematous dermatoses	Clinical Trial	Total Patients: 111	Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

Study Summary	Study Type	Studied Population	Results

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Study Summary	Study Type	Studied Population	Results
📄 Halobetasol propionate cream was found to be as effective as two other steroid creams (clobetasol and betamethasone) in treating severe atopic dermatitis. About 88-90% of patients showed significant improvement, with effects starting within 3 days for about 40% of patients. Double-blind, comparative clinical trials with halobetasol propionate cream in patients with atopic dermatitis	Clinical Trial	Total Patients: 264 Severity: severe Age: Not available	All three treatments showed similar high effectiveness
📄 Halobetasol propionate ointment was more effective than diflucortolone valerate ointment in treating severe atopic dermatitis, with 91.5% of patients showing significant improvement compared to 83.6%. It also worked faster, with 70% of patients seeing improvements within 3 days, and had fewer side effects. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus	Clinical Trial	Total Patients: 120	Halobetasol propionate showed better overall success rate

Halobetasol is highly effective at treating eczema, with success rates between 88-94% across multiple studies. Most patients see significant improvement or complete healing of their eczema.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication works quickly, with many patients seeing improvements within the first 3 days of treatment. This fast action makes it particularly useful for quick relief of symptoms.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 224

Results:

Halobetasol was significantly more effective than vehicle in treating chronic eczema

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Severity: Chronic

Age: Not specified

Results:

Significant improvement in all symptoms compared to vehicle (p<0.001)

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not specified

Results:

All three treatments showed similar high success rates

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

The medication is generally well-tolerated with a low rate of side effects (2-5% of patients). The most common side effects are skin dryness, itching, or burning at the application site.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 111

Results:

Significant improvement in all symptoms compared to vehicle by day 7 and day 14 (p<0.001)

The medication performs as well as or better than other strong topical steroids like clobetasol propionate and betamethasone dipropionate, making it a reliable option for treating severe eczema.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 264

Severity: severe

Age: Not available

Results:

All three treatments showed similar high effectiveness

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Results:

Halobetasol propionate showed better overall success rate

LOWEST SIDE EFFECTS

Desonide (Desonide)

Who is this for?:

If you need a low-potency steroid treatment

Effectiveness:

Side Effects:

Low

Cost:

$35/month

Delivery:

Topical daily

See Evidence

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05%, a low-potency steroid, was found to be safe and effective in treating children aged 6 months to 6 years with moderate-to-severe atopic dermatitis. The treatment showed good results in improving symptoms while having minimal impact on the body's hormone system. Effect of desonide hydrogel 0.05% on the hypothalamic-pituitary-adrenal axis in pediatric subjects with moderate to severe atopic dermatitis	Clinical Trial	Total Patients: 40 Severity: moderate to severe Age: 6 months-6 years	Treatment was generally safe with minimal impact on the body's hormone system
📄 Both desonide 0.05% ointment and hydrocortisone 2.5% ointment were found to be safe for children with atopic dermatitis when used for 4 weeks. Neither medication affected the body's natural cortisol production system. Effect of desonide ointment, 0.05%, on the hypothalamic-pituitary-adrenal axis of children with atopic dermatitis	Clinical Trial		Both medications were safe for use in children and did not affect their natural cortisol production system
📄 Both desonide cream 0.1% and betamethasone cream were equally effective in treating childhood atopic dermatitis. However, desonide had less impact on the body's cortisol levels, making it potentially safer for children. [Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]	Clinical Trial	Total Patients: 29 Severity: Not specified Age: mean 13.8 months	Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Desonide hydrogel 0.05% was found to be safe and effective in treating mild to moderate atopic dermatitis in children aged 3 months to 18 years. The treatment was well-tolerated and showed significant improvements compared to the vehicle (gel without medication). Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis	Clinical Trial	Total Patients: 582	The medication showed significant improvement compared to the vehicle alone

Study Summary	Study Type	Studied Population	Results

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 40

Severity: moderate to severe

Age: 6 months-6 years

Results:

Treatment was generally safe with minimal impact on the body's hormone system

Summary:

Study Type:

Clinical Trial

Studied Population:

Results:

Both medications were safe for use in children and did not affect their natural cortisol production system

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 29

Severity: Not specified

Age: mean 13.8 months

Results:

Both treatments showed similar clinical effectiveness

The hydrogel form of desonide helps improve skin moisture and barrier function, with significant improvements seen in as little as 1-2 weeks of treatment.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 582

Results:

The medication showed significant improvement compared to the vehicle alone

Clobetasol (Clobetasol propionate)

Who is this for?:

If you need a super-high potency corticosteroid treatment (but should not be used for more than 2 weeks)

Effectiveness:

Side Effects:

Medium

Cost:

$25/month

Delivery:

Topical 2 daily

See Evidence

Buy Now — $25/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate cream 0.05% was tested against a vehicle (cream without active ingredient) in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate, a very strong topical steroid, was more effective than flupredniden acetate (medium strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Study Summary	Study Type	Studied Population	Results

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol propionate (a very strong steroid) was more effective than flupredniden acetate (a medium-strength steroid) in preventing hand eczema from coming back. When using clobetasol twice weekly, 70% of patients remained free from eczema flares compared to 30% with flupredniden. Intermittent maintenance therapy in chronic hand eczema with clobetasol propionate and flupredniden acetate	Clinical Trial	Total Patients: 55	Clobetasol was more effective at preventing relapses when used twice weekly

Study Summary	Study Type	Studied Population	Results
📄 Clobetasol cream was more effective than fluocinonide cream in treating eczema when applied three times daily for 2 weeks. Clobetasol showed faster healing and fewer side effects (4%) compared to fluocinonide (12%). Clobetasol propionate versus fluocinonide creams in psoriasis and eczema	Clinical Trial	Total Patients: 113 Severity: not available Age: adolescent and adult	Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week
📄 Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application. Clobetasol propionate emollient 0.05% in the treatment of atopic dermatitis	Clinical Trial	Total Patients: 81 Severity: moderate to severe Age: ≥12 years	not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

Study Summary	Study Type	Studied Population	Results

Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Results:

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses than flupredniden

The medication comes in different forms (cream, lotion, ointment) with similar effectiveness, though the lotion form may provide better long-term results after stopping treatment

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

When used twice weekly for maintenance therapy, clobetasol can help prevent eczema from coming back. In one study, 70% of patients remained free from relapses using this approach.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 55

Results:

Clobetasol was more effective at preventing relapses when used twice weekly

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 113

Severity: not available

Age: adolescent and adult

Results:

Clobetasol showed faster healing and maintained efficacy, while fluocinonide's healing rate slowed after first week

Summary:

Clobetasol propionate emollient cream 0.05% was tested against a placebo cream in patients with moderate-to-severe atopic dermatitis. The study lasted 4 weeks with twice daily application.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 81

Severity: moderate to severe

Age: ≥12 years

Results:

not available

Different formulations (cream, lotion, emollient) appear to be similarly effective, though some studies suggest the lotion form may provide better long-term results than the cream version.

Betamethasone (Betamethasone)

Who is this for?:

If you respond to corticosteroids

If you are 13 or older and responds to corticosteroids

Effectiveness:

Side Effects:

Medium

Cost:

$35/month

Delivery:

Topical 1-2 daily

See Evidence

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Betamethasone is effective at reducing inflammation and symptoms of eczema, with studies showing 76-94% of patients experiencing significant improvement within 2-3 weeks of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Both betamethasone and tacrolimus treatments effectively reduced eczema severity and inflammation. Betamethasone was better at reducing inflammation, while tacrolimus was better at improving skin hydration. Skin and systemic inflammation in adults with atopic dermatitis before and after whole-body topical betamethasone 17-valerate 0.1% or tacrolimus 0.1% treatment: A randomized controlled study	Randomized Controlled Trial	Total Patients: 36 Severity: moderate Age: 18+	Both treatments effectively reduced disease severity

Study Summary	Study Type	Studied Population	Results
📄 Both betamethasone and pimecrolimus improved skin barrier function and reduced symptoms in atopic dermatitis. While betamethasone was better at reducing symptoms, it caused skin thinning, making pimecrolimus potentially better for long-term use. Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis	Randomized Controlled Trial	Total Patients: 15 Severity: not available Age: not available	Betamethasone was more effective at reducing clinical symptoms
📄 Betamethasone was more effective at reducing inflammation compared to pimecrolimus in atopic dermatitis skin samples. However, betamethasone may impair skin barrier repair, while pimecrolimus helps maintain it, suggesting pimecrolimus might be better for long-term treatment. Gene expression is differently affected by pimecrolimus and betamethasone in lesional skin of atopic dermatitis	Clinical Trial	Severity: not available Age: not available
📄 In people with controlled atopic dermatitis, betamethasone cream damaged the skin barrier after 4 weeks of use, while tacrolimus ointment improved skin barrier function. Tacrolimus was better at maintaining skin hydration and natural moisturizing factors. The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis	Randomized Controlled Trial	Total Patients: 20	Tacrolimus was superior to betamethasone for maintaining skin barrier health

When combined with antibacterial agents like fusidic acid, betamethasone is more effective at treating infected eczema, eliminating 67% of bacteria compared to 51% with betamethasone alone.

Study Summary	Study Type	Studied Population	Results
📄 A new cream containing fusidic acid and betamethasone (Fucicort Lipid cream) was found to be as effective as the existing cream formulation in treating infected atopic dermatitis. Both creams reduced severity scores by about 83% and cleared bacterial infection in about 90% of patients after 2 weeks of treatment. An efficient new formulation of fusidic acid and betamethasone 17-valerate (fucicort lipid cream) for treatment of clinically infected atopic dermatitis	Randomized Controlled Trial	Total Patients: 629 Severity: Not specified Age: Not specified	Both Fucicort formulations showed similar effectiveness, significantly better than vehicle

Alternative treatments like tacrolimus or pimecrolimus may be better for long-term use as they improve skin barrier function without causing the skin thinning associated with betamethasone.

Study Summary	Study Type	Studied Population	Results
📄 Both tacrolimus and betamethasone improved skin barrier function during treatment. However, after stopping treatment, the benefits lasted longer with tacrolimus while the improvement from betamethasone partially wore off. Comparative effect of tacrolimus and betamethasone valerate on the passive sustainable hydration of the stratum corneum in atopic dermatitis	Randomized Controlled Trial	Total Patients: 21 Severity: moderate Age: not available	Both treatments improved skin barrier function, but tacrolimus benefits lasted longer after stopping treatment
📄 In people with controlled atopic dermatitis, betamethasone cream damaged the skin barrier after 4 weeks of use, while tacrolimus ointment improved skin barrier function. Tacrolimus was better at maintaining skin hydration and natural moisturizing factors. The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis	Randomized Controlled Trial	Total Patients: 20	Tacrolimus was superior to betamethasone for maintaining skin barrier health
📄 Both betamethasone and pimecrolimus improved skin barrier function and reduced symptoms in atopic dermatitis. While betamethasone was better at reducing symptoms, it caused skin thinning, making pimecrolimus potentially better for long-term use. Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis	Randomized Controlled Trial	Total Patients: 15 Severity: not available Age: not available	Betamethasone was more effective at reducing clinical symptoms

Betamethasone is effective at reducing inflammation and symptoms of eczema, with studies showing 76-94% of patients experiencing significant improvement within 2-3 weeks of treatment.

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 36

Severity: moderate

Age: 18+

Results:

Both treatments effectively reduced disease severity

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 15

Severity: not available

Age: not available

Results:

Betamethasone was more effective at reducing clinical symptoms

Summary:

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: not available

Results:

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 20

Results:

Tacrolimus was superior to betamethasone for maintaining skin barrier health

When combined with antibacterial agents like fusidic acid, betamethasone is more effective at treating infected eczema, eliminating 67% of bacteria compared to 51% with betamethasone alone.

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 629

Severity: Not specified

Age: Not specified

Results:

Both Fucicort formulations showed similar effectiveness, significantly better than vehicle

Alternative treatments like tacrolimus or pimecrolimus may be better for long-term use as they improve skin barrier function without causing the skin thinning associated with betamethasone.

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 21

Severity: moderate

Age: not available

Results:

Both treatments improved skin barrier function, but tacrolimus benefits lasted longer after stopping treatment

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 20

Results:

Tacrolimus was superior to betamethasone for maintaining skin barrier health

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 15

Severity: not available

Age: not available

Results:

Betamethasone was more effective at reducing clinical symptoms

Mometasone (Mometasone furoate)

Who is this for?:

If you respond to corticosteroids

If you respond to corticosteroids and need short-term relief through a very strong steroid

Effectiveness:

Side Effects:

Medium

Cost:

$35/month

Delivery:

Topical daily

See Evidence

Buy Now — $35/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Mometasone furoate cream is effective in treating atopic dermatitis, with success rates ranging from 80% to 90%. It can be used once daily, making it convenient for patients.

Study Summary	Study Type	Studied Population	Results
📄 Using mometasone cream together with an Alginate Skin Repair Mask was more effective than using mometasone cream alone for treating atopic dermatitis. The combination treatment showed better results with 97.5% effectiveness compared to 80% for cream alone, and had fewer side effects and disease recurrences. Efficacy of Mometasone Furoate Cream Sodium Alginate Skin Repair Mask in Atopic Dermatitis Treatment	Randomized Controlled Trial	Total Patients: 80 Severity: Not specified Age: 20-47 years	Combination therapy resulted in significantly lower SCORAD scores

Study Summary	Study Type	Studied Population	Results
📄 In children with mild to moderate eczema, neither mometasone furoate 0.1% nor tacrolimus 0.1% affected their short-term growth rates. This suggests these treatments are safe to use in children without concerns about growth suppression. Short-term growth in children with eczema during treatment with topical mometasone furoate and tacrolimus	Randomized Controlled Trial	Total Patients: 20 Severity: mild to moderate Age: 5-12 years	No statistically significant effect on growth rate was observed with either treatment

Study Summary	Study Type	Studied Population	Results
📄 Long-term intermittent treatment with mometasone furoate cream was effective for chronic hand eczema. Using the cream 3 times per week was more effective than using it 2 times per week or stopping treatment, with 83% of patients having no recurrence when using it 3 times weekly. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate	Clinical Trial	Total Patients: 120 Severity: chronic hand eczema Age: not available	Three-times-weekly maintenance therapy was most effective at preventing recurrence

Study Summary	Study Type	Studied Population	Results
📄 Using mometasone cream together with an Alginate Skin Repair Mask was more effective than using mometasone cream alone for treating atopic dermatitis. The combination treatment showed better results with 97.5% effectiveness compared to 80% for cream alone, and had fewer side effects and disease recurrences. Efficacy of Mometasone Furoate Cream Sodium Alginate Skin Repair Mask in Atopic Dermatitis Treatment	Randomized Controlled Trial	Total Patients: 80 Severity: Not specified Age: 20-47 years	Combination therapy resulted in significantly lower SCORAD scores
📄 Both mometasone and fluticasone ointments were effective in treating moderate to severe atopic dermatitis in children. Using wet wrap dressings after 2 weeks of treatment provided additional improvement in symptoms. The effectiveness of wet wrap dressings using 0.1% mometasone furoate and 0.005% fluticasone proprionate ointments in the treatment of moderate to severe atopic dermatitis in children	Clinical Trial	Total Patients: 40 Severity: moderate to severe Age: children (age range not specified)	Both treatments were effective, with additional benefits when wet wraps were added

Mometasone furoate cream is effective in treating atopic dermatitis, with success rates ranging from 80% to 90%. It can be used once daily, making it convenient for patients.

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 80

Severity: Not specified

Age: 20-47 years

Results:

Combination therapy resulted in significantly lower SCORAD scores

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 20

Severity: mild to moderate

Age: 5-12 years

Results:

No statistically significant effect on growth rate was observed with either treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 120

Severity: chronic hand eczema

Age: not available

Results:

Three-times-weekly maintenance therapy was most effective at preventing recurrence

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 80

Severity: Not specified

Age: 20-47 years

Results:

Combination therapy resulted in significantly lower SCORAD scores

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 40

Severity: moderate to severe

Age: children (age range not specified)

Results:

Both treatments were effective, with additional benefits when wet wraps were added

Triamcinolone acetonide (Triamcinolone acetonide)

Who is this for?:

If you are looking for short-term relief through a potent topical corticosteroid

Effectiveness:

Side Effects:

Medium

Cost:

$30/month

Delivery:

Topical 1-2 daily

See Evidence

Buy Now — $30/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Triamcinolone acetonide is effective at reducing inflammation and improving symptoms of atopic dermatitis, with significant improvements seen within 2-4 weeks of treatment

Study Summary	Study Type	Studied Population	Results
📄 A cream containing triamcinolone acetonide combined with laurocapram was more effective at treating atopic dermatitis compared to triamcinolone acetonide alone or vehicle control. The combination improved redness, skin thickness, and itching with minimal side effects. Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis	Clinical Trial	Total Patients: 150	TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control
📄 Adding tetracycline to triamcinolone acetonide (a steroid) cream did not improve eczema symptoms more than using triamcinolone acetonide alone. However, the combination did reduce bacterial skin infection better than the steroid alone. A randomized, double-blind study to assess the efficacy of addition of tetracycline to triamcinolone acetonide in the treatment of moderate to severe atopic dermatitis	Randomized Controlled Trial	Total Patients: 44

Study Summary	Study Type	Studied Population	Results
📄 Both cream and ointment forms of triamcinolone acetonide were equally effective when used with wet wraps for treating atopic dermatitis in children. While patients found the ointment more difficult to apply, they preferred it for future treatments. Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: A randomized split-body control study	Randomized Controlled Trial	Total Patients: 39 Severity: not available Age: pediatric	No significant difference in effectiveness between cream and ointment formulations

Triamcinolone acetonide appears to be safe, with only minor local reactions reported in a small number of patients (around 4-6% of users)

Study Summary	Study Type	Studied Population	Results
📄 A cream containing triamcinolone acetonide combined with laurocapram was more effective at treating atopic dermatitis compared to triamcinolone acetonide alone or vehicle control. The combination improved redness, skin thickness, and itching with minimal side effects. Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis	Clinical Trial	Total Patients: 150	TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control

Surprisingly, even very low doses of triamcinolone acetonide (40 times lower than typical commercial products) can be effective at reducing inflammation in mild to moderate atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 A low-dose steroid cream (triamcinolone acetonide) at 25 microg/g concentration was effective in treating mild to moderate atopic dermatitis. The low-dose steroid showed significant improvement compared to the cream without steroid after just one week of treatment. Low-dose triamcinolone acetonide in the phytocosmetic lichtena reduces inflammation in mild to moderate atopic dermatitis	Randomized Controlled Trial	Total Patients: 14	Low-dose steroid cream showed significant improvement in SCORAD scores starting from week 1, while the plain cream showed no improvement

Triamcinolone acetonide is effective at reducing inflammation and improving symptoms of atopic dermatitis, with significant improvements seen within 2-4 weeks of treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 150

Results:

TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 44

Results:

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 39

Severity: not available

Age: pediatric

Results:

No significant difference in effectiveness between cream and ointment formulations

Triamcinolone acetonide appears to be safe, with only minor local reactions reported in a small number of patients (around 4-6% of users)

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 150

Results:

TNX showed significantly higher improvement in signs and symptoms compared to both TN and vehicle control

Surprisingly, even very low doses of triamcinolone acetonide (40 times lower than typical commercial products) can be effective at reducing inflammation in mild to moderate atopic dermatitis

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 14

Results:

Low-dose steroid cream showed significant improvement in SCORAD scores starting from week 1, while the plain cream showed no improvement

Hydrocortisone cream (Hydrocortisone)

Who is this for?:

For temporary relief of itch and rashes

Effectiveness:

Side Effects:

Medium

Cost:

$25/month

Delivery:

Topical 1-4 daily

See Evidence

Buy Hydrocortisone cream

No prescription needed

KEY TAKEAWAYS

Topical corticosteroids are effective as a first-line treatment for atopic dermatitis, with studies showing significant improvement in symptoms within weeks of proper use

Study Summary	Study Type	Studied Population	Results
📄 A spray form of the steroid desoximetasone was tested in adults with atopic dermatitis. The spray significantly reduced itch and improved symptoms within 1 week, and these improvements lasted throughout the 4-week study. No side effects were reported. Efficacy and Safety of Desoximetasone 0.25% Spray in Adult Atopic Dermatitis Subjects: Pilot Study. (2017)	Clinical Trial	Severity: not available Age: 18+	Skin appearance improved within 1 week and stayed better for 4 weeks
📄 Using a strong steroid cream (fluticasone) worked better than a mild steroid cream (hydrocortisone) for treating moderate eczema flare-ups in children. Children using the stronger steroid had better symptom improvement and quality of life over 24 weeks. Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial (2024)	Randomized Controlled Trial	Total Patients: 32 Severity: moderate Age: 3 months-17 years	Strong steroid showed significantly better symptom control throughout the study period
📄 The study compared two ways of applying steroid cream in children with eczema - either on wet skin after a bath (soak and smear) or on dry skin. Both methods worked equally well, improving eczema by about 80-85%. A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD). (2016)	Randomized Controlled Trial	Total Patients: 45 Severity: not available Age: children (specific range not available)	Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Potent (stronger) topical corticosteroids may be more effective than mild ones for moderate flare-ups, showing better symptom improvement and quality of life scores over 24 weeks

Study Summary	Study Type	Studied Population	Results
📄 Using a strong steroid cream (fluticasone) worked better than a mild steroid cream (hydrocortisone) for treating moderate eczema flare-ups in children. Children using the stronger steroid had better symptom improvement and quality of life over 24 weeks. Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial (2024)	Randomized Controlled Trial	Total Patients: 32 Severity: moderate Age: 3 months-17 years	Strong steroid showed significantly better symptom control throughout the study period

The method of applying topical steroids (whether to wet or dry skin) does not significantly affect treatment outcomes, suggesting flexibility in application methods

Study Summary	Study Type	Studied Population	Results
📄 The study compared two ways of applying steroid cream in children with eczema - either on wet skin after a bath (soak and smear) or on dry skin. Both methods worked equally well, improving eczema by about 80-85%. A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD). (2016)	Randomized Controlled Trial	Total Patients: 45 Severity: not available Age: children (specific range not available)	Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Topical corticosteroids are effective as a first-line treatment for atopic dermatitis, with studies showing significant improvement in symptoms within weeks of proper use

Summary:

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: 18+

Results:

Skin appearance improved within 1 week and stayed better for 4 weeks

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 32

Severity: moderate

Age: 3 months-17 years

Results:

Strong steroid showed significantly better symptom control throughout the study period

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 45

Severity: not available

Age: children (specific range not available)

Results:

Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Potent (stronger) topical corticosteroids may be more effective than mild ones for moderate flare-ups, showing better symptom improvement and quality of life scores over 24 weeks

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 32

Severity: moderate

Age: 3 months-17 years

Results:

Strong steroid showed significantly better symptom control throughout the study period

The method of applying topical steroids (whether to wet or dry skin) does not significantly affect treatment outcomes, suggesting flexibility in application methods

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 45

Severity: not available

Age: children (specific range not available)

Results:

Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

Fluocinonide (Fluocinonide)

Who is this for?:

If you need a strong topical steroid

Effectiveness:

Side Effects:

Medium

Cost:

$30/month

Delivery:

Topical daily

See Evidence

Discuss with a Dermatologist

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 A 3-day treatment with fluocinonide cream showed high patient adherence (100%) and significant improvement in eczema symptoms. By day 14, patients experienced 79% reduction in itching and 76% improvement in eczema severity, with more than half of patients achieving clear or almost clear skin. Improvement in treatment adherence with a 3-day course of fluocinonide cream 0.1% for atopic dermatitis	Clinical Trial	Total Patients: 20 Severity: mild to severe Age: not available	Significant reduction in itching after treatment
📄 A two-week treatment with fluocinonide 0.1% cream improved skin barrier function and reduced symptoms in patients with moderate-to-severe atopic dermatitis. 28% of patients achieved clear or almost clear skin after treatment. Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis	Clinical Trial	Total Patients: 25	Significant improvement in eczema severity

Study Summary	Study Type	Studied Population	Results
📄 Fluocinonide cream 0.1% was found to be safe and effective when used once daily in children with moderate to severe atopic dermatitis. Over 90% of patients showed improvement in their condition, and applying it once daily was as effective as twice daily with lower risk of side effects. An open-label adrenal suppression study of 0.1% fluocinonide cream in pediatric patients with atopic dermatitis	Randomized Controlled Trial		Treatment was highly effective with both once-daily and twice-daily application
📄 A two-week treatment with fluocinonide 0.1% cream improved skin barrier function and reduced symptoms in patients with moderate-to-severe atopic dermatitis. 28% of patients achieved clear or almost clear skin after treatment. Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis	Clinical Trial	Total Patients: 25	Significant improvement in eczema severity

Short-term use (2-3 weeks) of fluocinonide actually helps improve the skin barrier function in people with atopic dermatitis, though long-term use should be avoided as it can cause skin thinning.

Study Summary	Study Type	Studied Population	Results
📄 A two-week treatment with fluocinonide 0.1% cream improved skin barrier function and reduced symptoms in patients with moderate-to-severe atopic dermatitis. 28% of patients achieved clear or almost clear skin after treatment. Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis	Clinical Trial	Total Patients: 25	Significant improvement in eczema severity

Studies show fluocinonide is more effective than some other topical steroids like halcinonide for treating atopic dermatitis.

Study Summary	Study Type	Studied Population	Results

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 20

Severity: mild to severe

Age: not available

Results:

Significant reduction in itching after treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 25

Results:

Significant improvement in eczema severity

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Results:

Treatment was highly effective with both once-daily and twice-daily application

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 25

Results:

Significant improvement in eczema severity

Short-term use (2-3 weeks) of fluocinonide actually helps improve the skin barrier function in people with atopic dermatitis, though long-term use should be avoided as it can cause skin thinning.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 25

Results:

Significant improvement in eczema severity

Studies show fluocinonide is more effective than some other topical steroids like halcinonide for treating atopic dermatitis.

Prednisone (Prednisone)

Who is this for?:

If you're open to steroids and topical treatments haven't worked for you

If you're open to steroids and growth suppression is not a concern

Effectiveness:

Side Effects:

Medium

Cost:

$25/month

Delivery:

Oral daily

See Evidence

Buy Now — $25/mo

Plus $45 one-time consultation fee

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Ciclosporin was found to be more effective than prednisolone for treating severe eczema in adults. Only 1 out of 21 patients on prednisolone achieved stable improvement compared to 6 out of 17 patients on ciclosporin. The study was stopped early due to many patients on prednisolone experiencing significant worsening of their eczema. Prednisolone vs. ciclosporin for severe adult eczema. An investigator-initiated double-blind placebo-controlled multicentre trial	Randomized Controlled Trial	Total Patients: 38	Ciclosporin was significantly more effective than prednisolone

Study Summary	Study Type	Studied Population	Results
📄 Using methylprednisolone aceponate cream twice weekly along with moisturizer was more effective at preventing eczema flares than using moisturizer alone. After 16 weeks, 87.1% of patients using the steroid cream remained free from flares compared to 65.8% using just moisturizer. Reduction of relapses of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient: a multicentre, randomized, double-blind, controlled study	Randomized Controlled Trial	Total Patients: 249	Patients using the steroid cream were 3.5 times less likely to experience a relapse

Topical methylprednisolone aceponate provides fast itch relief, with patients experiencing significant reduction in itching within 1-2 days of starting treatment.

Study Summary	Study Type	Studied Population	Results
📄 In a study of experimental eczema caused by nickel allergy, methylprednisolone aceponate (a topical corticosteroid) provided fast itch relief. On average, significant itch relief was achieved within 1 day of treatment. Fast itch relief in an experimental model for methylprednisolone aceponate topical corticosteroid activity, based on allergic contact eczema to nickel sulphate	Clinical Trial	Total Patients: 16 Severity: not available Age: not available	Treatment provided fast and effective itch relief

Study Summary	Study Type	Studied Population	Results
📄 Both methylprednisolone aceponate 0.1% ointment and tacrolimus 0.03% ointment were effective in treating severe atopic dermatitis in children and adolescents. Methylprednisolone showed better results for reducing itch and improving sleep, and was more cost-effective. Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with an acute flare of severe atopic dermatitis	Randomized Controlled Trial	Total Patients: 265 Severity: severe to very severe Age: children and adolescents	Both treatments were equally effective in achieving clear or almost clear skin

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 38

Results:

Ciclosporin was significantly more effective than prednisolone

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 249

Results:

Patients using the steroid cream were 3.5 times less likely to experience a relapse

Topical methylprednisolone aceponate provides fast itch relief, with patients experiencing significant reduction in itching within 1-2 days of starting treatment.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 16

Severity: not available

Age: not available

Results:

Treatment provided fast and effective itch relief

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 265

Severity: severe to very severe

Age: children and adolescents

Results:

Both treatments were equally effective in achieving clear or almost clear skin

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