This paper compares two steroid creams (clobetasol propionate and fluocinonide) to see which works better for treating psoriasis and eczema. The study looked at how well each cream worked and how safe they were.
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Clobetasol propionate versus fluocinonide creams in psoriasis and eczema
Clobetasol propionate versus fluocinonide creams in psoriasis and eczema
B Jegasothy, C Jacobson, N Levine, L Millikan, E Olsen, S Pinnell, G Cole, G Weinstein, M Porter
DOI: 10.1111/j.1365-4362.1985.tb05821.x
Controlled Clinical Trial
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113 participants
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1985
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4 citations
Key insights related to Clobetasol from this study:
- Clobetasol propionate is a highly effective treatment for eczema, with studies showing significant improvement in symptoms like redness, itching, and inflammation within 2-4 weeks of treatment
- The medication can be safely used with minimal side effects when used as directed. Side effects, when they occur, are generally mild and affect about 4% of patients
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What is this paper about?
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How did the authors study this?
The researchers conducted a double-blind study where patients applied either clobetasol or fluocinonide cream three times daily for 2 weeks. They evaluated the results through doctors' assessments, measurement of specific symptoms, and patients' own reports of improvement.
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What populations did the authors study?
The study included 113 patients with eczema and 114 with psoriasis who were adolescents and adults. No specific information was provided about disease severity or prior treatments.
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What did the authors find?
Clobetasol worked better and faster than fluocinonide for both conditions. Fewer side effects occurred with clobetasol (4% of patients) compared to fluocinonide (12% of patients). Some patients using clobetasol (6%) had temporary drops in their morning cortisol levels, but these returned to normal within a week after stopping treatment.
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What conclusions can we draw?
The authors concluded that clobetasol propionate cream was more effective than fluocinonide for treating both eczema and psoriasis. Both treatments were considered safe, though clobetasol had fewer side effects than fluocinonide.
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