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HIGHEST EFFICACY IN CATEGORY

Zyrtec

(Cetirizine)

If your AD is related to allergies

Oral daily

Low

Side Effect	Affected
Urticaria (skin rash)	5%

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KEY TAKEAWAYS

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine helped reduce itching and other symptoms of atopic dermatitis in adults, with better results at higher doses (40mg). The medication was most effective at reducing itching, redness, and skin thickening compared to placebo. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults	Clinical Trial	Total Patients: 178 Severity: not available Age: 18+	Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment. Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis. ETAC Study Group. Early Treatment of the Atopic Child	Clinical Trial	Total Patients: 817 Severity: not available Age: 12-24 months	This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Long-term use of cetirizine in infants with atopic dermatitis helped reduce the need for stronger topical steroids, especially in patients with more severe disease. The medication also significantly reduced the occurrence of hives compared to placebo (5.8% vs 16.2%). Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months	Clinical Trial	Total Patients: 817 Severity: not specified Age: 12-24 months

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Study Summary	Study Type	Studied Population	Results
📄 In infants with atopic dermatitis who were allergic to grass pollen or house dust mites, cetirizine treatment for 18 months helped prevent or delay the development of asthma. This protective effect was particularly strong and lasted for 36 months in children allergic to grass pollen. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up	Clinical Trial	Severity: not available Age: 1-2 years	Cetirizine prevented/delayed asthma development in sensitized infants

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Summary:

Cetirizine helped reduce itching and other symptoms of atopic dermatitis in adults, with better results at higher doses (40mg). The medication was most effective at reducing itching, redness, and skin thickening compared to placebo.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 178

Severity: not available

Age: 18+

Results:

Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Summary:

Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not available

Age: 12-24 months

Results:

This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Summary:

Long-term use of cetirizine in infants with atopic dermatitis helped reduce the need for stronger topical steroids, especially in patients with more severe disease. The medication also significantly reduced the occurrence of hives compared to placebo (5.8% vs 16.2%).

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not specified

Age: 12-24 months

Results:

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Summary:

In infants with atopic dermatitis who were allergic to grass pollen or house dust mites, cetirizine treatment for 18 months helped prevent or delay the development of asthma. This protective effect was particularly strong and lasted for 36 months in children allergic to grass pollen.

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: 1-2 years

Results:

Cetirizine prevented/delayed asthma development in sensitized infants

NONE

Allegra

(Fexofenadine)

If your AD is related to allergies

Oral daily

Low

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KEY TAKEAWAYS

When combined with topical corticosteroids, fexofenadine significantly reduces itching (pruritus) in people with atopic dermatitis. The improvement in itching can be noticed after just 1 day of treatment.

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Summary:

Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

LOWEST SIDE EFFECTS

Mupirocin

(Mupirocin)

If your AD is related to a bacterial infection (staphylococcus aureus)

Topical daily

Low

Side Effect	Affected
diarrhea
nausea

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KEY TAKEAWAYS

Mupirocin combined with steroid creams (like hydrocortisone or fluticasone) is effective and safe for treating atopic dermatitis, especially when there might be bacterial infection present. In one study, 74% of patients improved with this combination treatment.

Study Summary	Study Type	Studied Population	Results
📄 Using hydrocortisone cream combined with mupirocin was more effective (74% success) than hydrocortisone alone (65% success) or moisturizer (36% success) in treating mild to moderate atopic dermatitis in infants. The combination treatment was safe and helped address potential bacterial infection. Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age - a randomized double blind pilot trial	Randomized Controlled Trial	Total Patients: 83	Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient
📄 A combination ointment containing fluticasone propionate and mupirocin was effective in treating atopic dermatitis with suspected bacterial infection. After 2 weeks of treatment, the majority of patients (67.2%) had only mild disease, and patient comfort improved from 33.65% to 78.60%. Efficacy and safety of combination ointment "fluticasone propionate 0.005% plus mupirocin 2.0%" for the treatment of atopic dermatitis with clinical suspicion of secondary bacterial infection: an open label uncontrolled study	Clinical Trial	Total Patients: 122 Severity: mild to severe Age: not available	Significant improvement in disease severity with majority of patients achieving mild disease status

Mupirocin cream is as effective as oral antibiotics (like cephalexin) for treating infected eczema, with fewer side effects. It's also preferred by patients because it's applied directly to the skin rather than taken as pills.

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin

While mupirocin can effectively reduce bacteria (particularly Staphylococcus aureus) on the skin during treatment, bacteria levels may return to normal after stopping treatment. However, this doesn't necessarily mean symptoms will get worse.

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Summary:

Using hydrocortisone cream combined with mupirocin was more effective (74% success) than hydrocortisone alone (65% success) or moisturizer (36% success) in treating mild to moderate atopic dermatitis in infants. The combination treatment was safe and helped address potential bacterial infection.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 83

Results:

Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient

Summary:

A combination ointment containing fluticasone propionate and mupirocin was effective in treating atopic dermatitis with suspected bacterial infection. After 2 weeks of treatment, the majority of patients (67.2%) had only mild disease, and patient comfort improved from 33.65% to 78.60%.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 122

Severity: mild to severe

Age: not available

Results:

Significant improvement in disease severity with majority of patients achieving mild disease status

Summary:

Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

LOWEST SIDE EFFECTS

Claritin

(Loratadine)

If your AD is related to allergies

Oral daily

Low

Side Effect	Affected
somnolence/sedation

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KEY TAKEAWAYS

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Study Summary	Study Type	Studied Population	Results
📄 Loratadine significantly reduced itching (pruritus) in patients with atopic dermatitis compared to placebo, both during day and night. At least 9 out of 16 patients responded positively to the treatment. Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study	Clinical Trial	Total Patients: 16	Majority of patients (at least 56%) responded positively to loratadine treatment
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

Loratadine is as effective as hydroxyzine (another antihistamine) for treating symptoms, but causes much less drowsiness. Only 5% of patients on loratadine reported feeling sleepy compared to 40% of those taking hydroxyzine.

Study Summary	Study Type	Studied Population	Results
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Study Summary	Study Type	Studied Population	Results
📄 The study found that adding loratadine (an antihistamine) to mometasone cream treatment did not provide additional benefits for children with atopic dermatitis. The mometasone cream alone was very effective in treating the condition. Therapeutic efficacy and safety of loratadine syrup in childhood atopic dermatitis treated with mometasone furoate 0.1 per cent cream	Clinical Trial	Total Patients: 48 Severity: not available Age: mean age 73.67 months (approximately 6 years)	Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Study Summary	Study Type	Studied Population	Results
📄 The combination of desloratadine citrate and compound glycyrrhizin was more effective in treating subacute eczema compared to compound glycyrrhizin alone. The combination therapy showed lower inflammation markers and fewer side effects. Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial	Randomized Controlled Trial	Total Patients: 100 Severity: subacute Age: not available	The combination therapy was more effective in reducing inflammation

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Summary:

Loratadine significantly reduced itching (pruritus) in patients with atopic dermatitis compared to placebo, both during day and night. At least 9 out of 16 patients responded positively to the treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 16

Results:

Majority of patients (at least 56%) responded positively to loratadine treatment

Summary:

Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Summary:

The study found that adding loratadine (an antihistamine) to mometasone cream treatment did not provide additional benefits for children with atopic dermatitis. The mometasone cream alone was very effective in treating the condition.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 48

Severity: not available

Age: mean age 73.67 months (approximately 6 years)

Results:

Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Summary:

The combination of desloratadine citrate and compound glycyrrhizin was more effective in treating subacute eczema compared to compound glycyrrhizin alone. The combination therapy showed lower inflammation markers and fewer side effects.

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 100

Severity: subacute

Age: not available

Results:

The combination therapy was more effective in reducing inflammation

HIGHEST EFFICACY IN CATEGORY

Zyrtec (Cetirizine)

Who is this for?:

If your AD is related to allergies

Effectiveness:

Side Effects:

Low

Cost:

Share Cost of Medication

Delivery:

Oral daily

See Evidence

Get This Treatment

KEY TAKEAWAYS

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine helped reduce itching and other symptoms of atopic dermatitis in adults, with better results at higher doses (40mg). The medication was most effective at reducing itching, redness, and skin thickening compared to placebo. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults	Clinical Trial	Total Patients: 178 Severity: not available Age: 18+	Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment. Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis. ETAC Study Group. Early Treatment of the Atopic Child	Clinical Trial	Total Patients: 817 Severity: not available Age: 12-24 months	This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Long-term use of cetirizine in infants with atopic dermatitis helped reduce the need for stronger topical steroids, especially in patients with more severe disease. The medication also significantly reduced the occurrence of hives compared to placebo (5.8% vs 16.2%). Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months	Clinical Trial	Total Patients: 817 Severity: not specified Age: 12-24 months

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Study Summary	Study Type	Studied Population	Results
📄 In infants with atopic dermatitis who were allergic to grass pollen or house dust mites, cetirizine treatment for 18 months helped prevent or delay the development of asthma. This protective effect was particularly strong and lasted for 36 months in children allergic to grass pollen. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up	Clinical Trial	Severity: not available Age: 1-2 years	Cetirizine prevented/delayed asthma development in sensitized infants

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 178

Severity: not available

Age: 18+

Results:

Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Summary:

Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not available

Age: 12-24 months

Results:

This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not specified

Age: 12-24 months

Results:

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Summary:

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: 1-2 years

Results:

Cetirizine prevented/delayed asthma development in sensitized infants

NONE

Allegra (Fexofenadine)

Who is this for?:

If your AD is related to allergies

Effectiveness:

Side Effects:

Low

Cost:

Share Cost of Medication

Delivery:

Oral daily

See Evidence

Get This Treatment

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

LOWEST SIDE EFFECTS

Mupirocin (Mupirocin)

Who is this for?:

If your AD is related to a bacterial infection (staphylococcus aureus)

Effectiveness:

Side Effects:

Low

Cost:

Share Cost of Medication

Delivery:

Topical 3-4 daily

See Evidence

Get This Treatment

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Using hydrocortisone cream combined with mupirocin was more effective (74% success) than hydrocortisone alone (65% success) or moisturizer (36% success) in treating mild to moderate atopic dermatitis in infants. The combination treatment was safe and helped address potential bacterial infection. Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age - a randomized double blind pilot trial	Randomized Controlled Trial	Total Patients: 83	Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient
📄 A combination ointment containing fluticasone propionate and mupirocin was effective in treating atopic dermatitis with suspected bacterial infection. After 2 weeks of treatment, the majority of patients (67.2%) had only mild disease, and patient comfort improved from 33.65% to 78.60%. Efficacy and safety of combination ointment "fluticasone propionate 0.005% plus mupirocin 2.0%" for the treatment of atopic dermatitis with clinical suspicion of secondary bacterial infection: an open label uncontrolled study	Clinical Trial	Total Patients: 122 Severity: mild to severe Age: not available	Significant improvement in disease severity with majority of patients achieving mild disease status

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 83

Results:

Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 122

Severity: mild to severe

Age: not available

Results:

Significant improvement in disease severity with majority of patients achieving mild disease status

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

LOWEST SIDE EFFECTS

Claritin (Loratadine)

Who is this for?:

If your AD is related to allergies

Effectiveness:

Side Effects:

Low

Cost:

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Delivery:

Oral daily

See Evidence

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KEY TAKEAWAYS

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Study Summary	Study Type	Studied Population	Results
📄 Loratadine significantly reduced itching (pruritus) in patients with atopic dermatitis compared to placebo, both during day and night. At least 9 out of 16 patients responded positively to the treatment. Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study	Clinical Trial	Total Patients: 16	Majority of patients (at least 56%) responded positively to loratadine treatment
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

Study Summary	Study Type	Studied Population	Results
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Study Summary	Study Type	Studied Population	Results
📄 The study found that adding loratadine (an antihistamine) to mometasone cream treatment did not provide additional benefits for children with atopic dermatitis. The mometasone cream alone was very effective in treating the condition. Therapeutic efficacy and safety of loratadine syrup in childhood atopic dermatitis treated with mometasone furoate 0.1 per cent cream	Clinical Trial	Total Patients: 48 Severity: not available Age: mean age 73.67 months (approximately 6 years)	Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Study Summary	Study Type	Studied Population	Results
📄 The combination of desloratadine citrate and compound glycyrrhizin was more effective in treating subacute eczema compared to compound glycyrrhizin alone. The combination therapy showed lower inflammation markers and fewer side effects. Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial	Randomized Controlled Trial	Total Patients: 100 Severity: subacute Age: not available	The combination therapy was more effective in reducing inflammation

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 16

Results:

Majority of patients (at least 56%) responded positively to loratadine treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 48

Severity: not available

Age: mean age 73.67 months (approximately 6 years)

Results:

Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 100

Severity: subacute

Age: not available

Results:

The combination therapy was more effective in reducing inflammation

All Supportive & Adjunct Medications Treatments

Treatment

Who is this for?

Delivery

Effectiveness

Side Effects

Estimated Cost

HIGHEST EFFICACY IN CATEGORY

Zyrtec

(Cetirizine)

If your AD is related to allergies

Oral daily

Low

Side Effect	Affected
Urticaria (skin rash)	5%

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KEY TAKEAWAYS

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine helped reduce itching and other symptoms of atopic dermatitis in adults, with better results at higher doses (40mg). The medication was most effective at reducing itching, redness, and skin thickening compared to placebo. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults	Clinical Trial	Total Patients: 178 Severity: not available Age: 18+	Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment. Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis. ETAC Study Group. Early Treatment of the Atopic Child	Clinical Trial	Total Patients: 817 Severity: not available Age: 12-24 months	This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Long-term use of cetirizine in infants with atopic dermatitis helped reduce the need for stronger topical steroids, especially in patients with more severe disease. The medication also significantly reduced the occurrence of hives compared to placebo (5.8% vs 16.2%). Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months	Clinical Trial	Total Patients: 817 Severity: not specified Age: 12-24 months

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Study Summary	Study Type	Studied Population	Results
📄 In infants with atopic dermatitis who were allergic to grass pollen or house dust mites, cetirizine treatment for 18 months helped prevent or delay the development of asthma. This protective effect was particularly strong and lasted for 36 months in children allergic to grass pollen. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up	Clinical Trial	Severity: not available Age: 1-2 years	Cetirizine prevented/delayed asthma development in sensitized infants

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 178

Severity: not available

Age: 18+

Results:

Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Summary:

Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not available

Age: 12-24 months

Results:

This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not specified

Age: 12-24 months

Results:

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Summary:

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: 1-2 years

Results:

Cetirizine prevented/delayed asthma development in sensitized infants

NONE

Allegra

(Fexofenadine)

If your AD is related to allergies

Oral daily

Low

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KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

LOWEST SIDE EFFECTS

Mupirocin

(Mupirocin)

If your AD is related to a bacterial infection (staphylococcus aureus)

Topical daily

Low

Side Effect	Affected
diarrhea
nausea

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KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Using hydrocortisone cream combined with mupirocin was more effective (74% success) than hydrocortisone alone (65% success) or moisturizer (36% success) in treating mild to moderate atopic dermatitis in infants. The combination treatment was safe and helped address potential bacterial infection. Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age - a randomized double blind pilot trial	Randomized Controlled Trial	Total Patients: 83	Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient
📄 A combination ointment containing fluticasone propionate and mupirocin was effective in treating atopic dermatitis with suspected bacterial infection. After 2 weeks of treatment, the majority of patients (67.2%) had only mild disease, and patient comfort improved from 33.65% to 78.60%. Efficacy and safety of combination ointment "fluticasone propionate 0.005% plus mupirocin 2.0%" for the treatment of atopic dermatitis with clinical suspicion of secondary bacterial infection: an open label uncontrolled study	Clinical Trial	Total Patients: 122 Severity: mild to severe Age: not available	Significant improvement in disease severity with majority of patients achieving mild disease status

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 83

Results:

Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 122

Severity: mild to severe

Age: not available

Results:

Significant improvement in disease severity with majority of patients achieving mild disease status

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

LOWEST SIDE EFFECTS

Claritin

(Loratadine)

If your AD is related to allergies

Oral daily

Low

Side Effect	Affected
somnolence/sedation

Share Cost of Medication

Get This Treatment

KEY TAKEAWAYS

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Study Summary	Study Type	Studied Population	Results
📄 Loratadine significantly reduced itching (pruritus) in patients with atopic dermatitis compared to placebo, both during day and night. At least 9 out of 16 patients responded positively to the treatment. Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study	Clinical Trial	Total Patients: 16	Majority of patients (at least 56%) responded positively to loratadine treatment
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

Study Summary	Study Type	Studied Population	Results
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Study Summary	Study Type	Studied Population	Results
📄 The study found that adding loratadine (an antihistamine) to mometasone cream treatment did not provide additional benefits for children with atopic dermatitis. The mometasone cream alone was very effective in treating the condition. Therapeutic efficacy and safety of loratadine syrup in childhood atopic dermatitis treated with mometasone furoate 0.1 per cent cream	Clinical Trial	Total Patients: 48 Severity: not available Age: mean age 73.67 months (approximately 6 years)	Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Study Summary	Study Type	Studied Population	Results
📄 The combination of desloratadine citrate and compound glycyrrhizin was more effective in treating subacute eczema compared to compound glycyrrhizin alone. The combination therapy showed lower inflammation markers and fewer side effects. Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial	Randomized Controlled Trial	Total Patients: 100 Severity: subacute Age: not available	The combination therapy was more effective in reducing inflammation

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 16

Results:

Majority of patients (at least 56%) responded positively to loratadine treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 48

Severity: not available

Age: mean age 73.67 months (approximately 6 years)

Results:

Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 100

Severity: subacute

Age: not available

Results:

The combination therapy was more effective in reducing inflammation

Hydroxyzine

(Hydroxyzine)

If you need support for managing sleep and anxiety that worsens your eczema flare

Oral daily

Medium

Side Effect	Affected
somnolence/sedation
sedation

Share Cost of Medication

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KEY TAKEAWAYS

Hydroxyzine is effective at reducing itching (pruritus) in atopic dermatitis, with significant itch suppression lasting up to 24 hours after taking the medication. The best itch control (over 85% reduction) occurs between 2-12 hours after taking the medicine.

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

The medication can reduce daily symptoms of atopic dermatitis by about 38%, which is similar to other antihistamines like loratadine.

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

The main side effect is drowsiness/sedation, which is more common with hydroxyzine compared to newer antihistamines. In one study, 40% of patients on hydroxyzine reported feeling sleepy, compared to only 5% on loratadine.

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Both medications reduced symptoms more than placebo, with loratadine showing better efficacy
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

For children with atopic dermatitis, a lower dose (0.7 mg/kg three times daily) can be just as effective as a higher dose (1.4 mg/kg three times daily) while causing less drowsiness.

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

Summary:

Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results:

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

The medication can reduce daily symptoms of atopic dermatitis by about 38%, which is similar to other antihistamines like loratadine.

Summary:

Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

Summary:

Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results:

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

For children with atopic dermatitis, a lower dose (0.7 mg/kg three times daily) can be just as effective as a higher dose (1.4 mg/kg three times daily) while causing less drowsiness.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results:

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

HIGHEST EFFICACY IN CATEGORY

Zyrtec (Cetirizine)

Who is this for?:

If your AD is related to allergies

Effectiveness:

Side Effects:

Low

Cost:

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Delivery:

Oral daily

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KEY TAKEAWAYS

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine helped reduce itching and other symptoms of atopic dermatitis in adults, with better results at higher doses (40mg). The medication was most effective at reducing itching, redness, and skin thickening compared to placebo. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults	Clinical Trial	Total Patients: 178 Severity: not available Age: 18+	Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Study Summary	Study Type	Studied Population	Results
📄 Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment. Prospective, long-term safety evaluation of the H1-receptor antagonist cetirizine in very young children with atopic dermatitis. ETAC Study Group. Early Treatment of the Atopic Child	Clinical Trial	Total Patients: 817 Severity: not available Age: 12-24 months	This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Study Summary	Study Type	Studied Population	Results
📄 Long-term use of cetirizine in infants with atopic dermatitis helped reduce the need for stronger topical steroids, especially in patients with more severe disease. The medication also significantly reduced the occurrence of hives compared to placebo (5.8% vs 16.2%). Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months	Clinical Trial	Total Patients: 817 Severity: not specified Age: 12-24 months

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Study Summary	Study Type	Studied Population	Results
📄 In infants with atopic dermatitis who were allergic to grass pollen or house dust mites, cetirizine treatment for 18 months helped prevent or delay the development of asthma. This protective effect was particularly strong and lasted for 36 months in children allergic to grass pollen. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up	Clinical Trial	Severity: not available Age: 1-2 years	Cetirizine prevented/delayed asthma development in sensitized infants

Cetirizine is effective at reducing itching and other skin symptoms in both children and adults with atopic dermatitis

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 178

Severity: not available

Age: 18+

Results:

Higher doses of cetirizine were more effective at improving symptoms, with 40mg showing the best results

Long-term use of cetirizine is safe, even in young children. Studies showed no negative effects on behavior, thinking ability, or physical development when used for up to 18 months

Summary:

Cetirizine was found to be safe for long-term use in young children with atopic dermatitis. The medication showed similar or fewer side effects compared to placebo over 18 months of treatment.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not available

Age: 12-24 months

Results:

This was primarily a safety study

Cetirizine can help reduce the need for strong topical steroids in patients with moderate-to-severe atopic dermatitis

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 817

Severity: not specified

Age: 12-24 months

Results:

In children with atopic dermatitis who are allergic to grass pollen or dust mites, cetirizine may help prevent or delay the development of asthma

Summary:

Study Type:

Clinical Trial

Studied Population:

Severity: not available

Age: 1-2 years

Results:

Cetirizine prevented/delayed asthma development in sensitized infants

NONE

Allegra (Fexofenadine)

Who is this for?:

If your AD is related to allergies

Effectiveness:

Side Effects:

Low

Cost:

Share Cost of Medication

Delivery:

Oral daily

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KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Study Summary	Study Type	Studied Population	Results
📄 Adding fexofenadine (an antihistamine) to topical hydrocortisone helped reduce itching in patients with atopic dermatitis more effectively than hydrocortisone alone. The improvement in itching was seen after just 1 day of treatment and continued throughout the study week. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study	Clinical Trial	Total Patients: 400 Severity: not available Age: 16+	Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine helps reduce itching both during the day and at night, and can decrease the area of skin affected by itching.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

Fexofenadine is generally safe to use, with side effects similar to those experienced by people taking a placebo (sugar pill).

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 400

Severity: not available

Age: 16+

Results:

Fexofenadine significantly reduced itching compared to placebo, with improvements seen after 1 day and maintained throughout the week

LOWEST SIDE EFFECTS

Mupirocin (Mupirocin)

Who is this for?:

If your AD is related to a bacterial infection (staphylococcus aureus)

Effectiveness:

Side Effects:

Low

Cost:

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Delivery:

Topical 3-4 daily

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KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Using hydrocortisone cream combined with mupirocin was more effective (74% success) than hydrocortisone alone (65% success) or moisturizer (36% success) in treating mild to moderate atopic dermatitis in infants. The combination treatment was safe and helped address potential bacterial infection. Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age - a randomized double blind pilot trial	Randomized Controlled Trial	Total Patients: 83	Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient
📄 A combination ointment containing fluticasone propionate and mupirocin was effective in treating atopic dermatitis with suspected bacterial infection. After 2 weeks of treatment, the majority of patients (67.2%) had only mild disease, and patient comfort improved from 33.65% to 78.60%. Efficacy and safety of combination ointment "fluticasone propionate 0.005% plus mupirocin 2.0%" for the treatment of atopic dermatitis with clinical suspicion of secondary bacterial infection: an open label uncontrolled study	Clinical Trial	Total Patients: 122 Severity: mild to severe Age: not available	Significant improvement in disease severity with majority of patients achieving mild disease status

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Study Summary	Study Type	Studied Population	Results
📄 Mupirocin cream was found to be as effective as oral cephalexin (an antibiotic) for treating infected eczema. The cream worked better at killing bacteria and was preferred by patients over taking oral medication. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema	Clinical Trial	Total Patients: 159 Severity: secondarily infected eczema Age: not available	Mupirocin cream was similarly effective to oral cephalexin
📄 Mupirocin, a topical antibiotic, significantly reduced Staphylococcus aureus bacteria on the skin of atopic dermatitis patients and improved their symptoms. Although bacteria returned after stopping treatment, patients' symptoms didn't get worse during the study period. Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy	Clinical Trial	Total Patients: 49 Severity: not available Age: not available	Mupirocin significantly reduced bacterial counts

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 83

Results:

Combined treatment with hydrocortisone and mupirocin was most effective, followed by hydrocortisone alone, both significantly better than emollient

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 122

Severity: mild to severe

Age: not available

Results:

Significant improvement in disease severity with majority of patients achieving mild disease status

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

Short-term use of mupirocin appears to be safe, with minimal side effects. The most common side effects reported were mild and included diarrhea and nausea.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 159

Severity: secondarily infected eczema

Age: not available

Results:

Mupirocin cream was similarly effective to oral cephalexin

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 49

Severity: not available

Age: not available

Results:

Mupirocin significantly reduced bacterial counts

LOWEST SIDE EFFECTS

Claritin (Loratadine)

Who is this for?:

If your AD is related to allergies

Effectiveness:

Side Effects:

Low

Cost:

Share Cost of Medication

Delivery:

Oral daily

See Evidence

Get This Treatment

KEY TAKEAWAYS

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Study Summary	Study Type	Studied Population	Results
📄 Loratadine significantly reduced itching (pruritus) in patients with atopic dermatitis compared to placebo, both during day and night. At least 9 out of 16 patients responded positively to the treatment. Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study	Clinical Trial	Total Patients: 16	Majority of patients (at least 56%) responded positively to loratadine treatment
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

Study Summary	Study Type	Studied Population	Results
📄 Loratadine was found to be as effective as hydroxyzine in treating atopic dermatitis symptoms, reducing symptoms by 57%. Importantly, loratadine caused much less drowsiness than hydroxyzine, with only one patient reporting sleepiness compared to eight patients on hydroxyzine. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Study Summary	Study Type	Studied Population	Results
📄 The study found that adding loratadine (an antihistamine) to mometasone cream treatment did not provide additional benefits for children with atopic dermatitis. The mometasone cream alone was very effective in treating the condition. Therapeutic efficacy and safety of loratadine syrup in childhood atopic dermatitis treated with mometasone furoate 0.1 per cent cream	Clinical Trial	Total Patients: 48 Severity: not available Age: mean age 73.67 months (approximately 6 years)	Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Study Summary	Study Type	Studied Population	Results
📄 The combination of desloratadine citrate and compound glycyrrhizin was more effective in treating subacute eczema compared to compound glycyrrhizin alone. The combination therapy showed lower inflammation markers and fewer side effects. Desloratadine citrate combined with compound glycyrrhizin in the treatment of subacute eczema: A randomized trial	Randomized Controlled Trial	Total Patients: 100 Severity: subacute Age: not available	The combination therapy was more effective in reducing inflammation

Loratadine can help reduce itching (pruritus) in people with atopic dermatitis, both during the day and night. More than half of patients showed positive response to the treatment.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 16

Results:

Majority of patients (at least 56%) responded positively to loratadine treatment

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Loratadine showed better symptom reduction than both hydroxyzine and placebo

When used alongside strong topical steroids (like mometasone cream), loratadine may not provide additional benefits, though it remains safe to use with no serious side effects.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 48

Severity: not available

Age: mean age 73.67 months (approximately 6 years)

Results:

Both groups showed significant improvement, with no difference between loratadine and placebo groups (p = 0.99)

A newer version of loratadine (desloratadine) combined with other medications may be effective for treating eczema and reducing inflammation.

Summary:

Study Type:

Randomized Controlled Trial

Studied Population:

Total Patients: 100

Severity: subacute

Age: not available

Results:

The combination therapy was more effective in reducing inflammation

Hydroxyzine (Hydroxyzine)

Who is this for?:

If you need support for managing sleep and anxiety that worsens your eczema flare

Effectiveness:

Side Effects:

Medium

Cost:

Share Cost of Medication

Delivery:

Oral 3-4 daily

See Evidence

Get This Treatment

KEY TAKEAWAYS

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

The medication can reduce daily symptoms of atopic dermatitis by about 38%, which is similar to other antihistamines like loratadine.

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Both medications reduced symptoms more than placebo, with loratadine showing better efficacy
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

For children with atopic dermatitis, a lower dose (0.7 mg/kg three times daily) can be just as effective as a higher dose (1.4 mg/kg three times daily) while causing less drowsiness.

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results:

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

The medication can reduce daily symptoms of atopic dermatitis by about 38%, which is similar to other antihistamines like loratadine.

Summary:

Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

Summary:

Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.

Study Type:

Clinical Trial

Studied Population:

Total Patients: 41

Severity: not available

Age: 18-65

Results:

Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results:

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

For children with atopic dermatitis, a lower dose (0.7 mg/kg three times daily) can be just as effective as a higher dose (1.4 mg/kg three times daily) while causing less drowsiness.

Summary:

Study Type:

Clinical Trial

Studied Population:

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results:

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

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