This study tested whether loratadine (an antihistamine) could help reduce itching in people with atopic dermatitis. The researchers wanted to see if loratadine could provide relief from itching both during day and night.
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Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study
Therapeutic effect of loratadine on pruritus in patients with atopic dermatitis. A multi-crossover-designed study
T Langeland, H E Fagertun, S Larsen
DOI: 10.1111/j.1398-9995.1994.tb00768.x
Controlled Clinical Trial
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16 participants
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1994
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8 citations
Key insights related to Claritin from this study:
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What is this paper about?
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How did the authors study this?
The study was double-blind and placebo-controlled, meaning neither patients nor doctors knew who was getting the real medicine. Patients alternated between taking loratadine and placebo every 2 weeks. They recorded their itching levels twice daily using a 10-cm scale.
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What populations did the authors study?
The study included 16 patients with moderate or severe atopic dermatitis, with an average age of 24.8 years. All patients had significant itching as a symptom.
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What did the authors find?
Loratadine significantly reduced itching compared to placebo, both during day and night. It also improved the severity of skin rash. Nine out of 16 patients showed clear improvement with loratadine, while only one patient didn't respond to the treatment.
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What conclusions can we draw?
The authors concluded that loratadine could be useful as an additional treatment for people with moderate to severe atopic dermatitis who suffer from itching.
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