Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults

M Hannuksela, K Kalimo, K Lammintausta, T Mattila, K Turjanmaa, E Varjonen, P J Coulie

Clinical Trial

•

178 participants

•

1993

•

11 citations

Key insights related to Zyrtec from this study:

What is this paper about?

This paper studied how different doses of cetirizine (an antihistamine) affect atopic dermatitis symptoms in adults. The researchers compared placebo to three different doses of cetirizine (10mg, 20mg, and 40mg) taken daily for 4 weeks.
How did the authors study this?

This was a double-blind, randomized study comparing four groups of patients. They measured symptoms like itching (using visual scales), redness, blisters, scratching marks, and skin thickening across 14 body areas. All patients were allowed to use basic treatments like moisturizers and 1% hydrocortisone.
What populations did the authors study?

The study included 178 adults with atopic dermatitis, with 127 of them completing the study for effectiveness analysis.
What conclusions can we draw?

Cetirizine showed dose-dependent effectiveness in treating atopic dermatitis symptoms, with the 40mg dose being most effective. The medication was particularly helpful in reducing itching, even at lower doses.

Did this article interest you?

As a member of the Lemma Health community, you'll stay up to date with research, hear about new products, and get exclusive access to discounts.

At Lemma Health, we provide evidence-based skin care. Access providers in all 50 states. Receive your medications delivered.