This paper studies how hydroxyzine (an antihistamine medication) works in children with atopic dermatitis, looking at both how the body processes the drug and how well it helps with itching.
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Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis
Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis
F E Simons, K J Simons, A B Becker, R P Haydey
Clinical Trial
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12 participants
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1984
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14 citations
Key insights related to Hydroxyzine from this study:
- Hydroxyzine is effective at reducing itching (pruritus) in atopic dermatitis, with significant itch suppression lasting up to 24 hours after taking the medication. The best itch control (over 85% reduction) occurs between 2-12 hours after taking the medicine.
- The main side effect is drowsiness/sedation, which is more common with hydroxyzine compared to newer antihistamines. In one study, 40% of patients on hydroxyzine reported feeling sleepy, compared to only 5% on loratadine.
- For children with atopic dermatitis, a lower dose (0.7 mg/kg three times daily) can be just as effective as a higher dose (1.4 mg/kg three times daily) while causing less drowsiness.
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What is this paper about?
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How did the authors study this?
The researchers conducted two studies. First, they gave children a single dose of hydroxyzine and measured its levels in their blood over time. Then, they did a two-week study comparing two different doses of hydroxyzine to see which worked better for itching.
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What populations did the authors study?
The study included 12 children with severe atopic dermatitis, with an average age of 6.1 years.
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What conclusions can we draw?
The authors conclude that hydroxyzine effectively reduces itching in children with atopic dermatitis. They found that the lower dose (0.7 mg/kg three times daily) is just as effective as the higher dose but has fewer side effects, making it the better choice for treatment.
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