(2.91)
Based on 42 studies
| Side Effect | Affected |
|---|---|
| somnolence/sedation | |
| sedation |
Image for illustration purposes only. Actual medication may appear different.
Get Hydroxyzine
Consult with a board-certified medical professional
Image for illustration purposes only. Actual medication may appear different.
Highlights
- Reduces itch by >85% within 2-12 hours
- Itch control lasts up to 24 hours
- Reduces daily symptoms by 38%
- Drowsiness in 40% of patients
- Higher sedation risk compared to newer antihistamines
Hydroxyzine is effective at reducing itching (pruritus) in atopic dermatitis, with significant itch suppression lasting up to 24 hours after taking the medication. The best itch control (over 85% reduction) occurs between 2-12 hours after taking the medicine.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
|
📄
Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.
|
Clinical Trial |
Total Patients: 12
Severity: severe Age: children (mean 6.1 ± 4.6 years)
|
Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation |
Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.
Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitisThe medication can reduce daily symptoms of atopic dermatitis by about 38%, which is similar to other antihistamines like loratadine.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
|
📄
Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.
|
Clinical Trial |
Total Patients: 41
Severity: not available Age: 18-65
|
Both medications reduced symptoms more than placebo, with loratadine showing better efficacy |
Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.
Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitisThe main side effect is drowsiness/sedation, which is more common with hydroxyzine compared to newer antihistamines. In one study, 40% of patients on hydroxyzine reported feeling sleepy, compared to only 5% on loratadine.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
|
📄
Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.
|
Clinical Trial |
Total Patients: 41
Severity: not available Age: 18-65
|
Both medications reduced symptoms more than placebo, with loratadine showing better efficacy |
|
📄
Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.
|
Clinical Trial |
Total Patients: 12
Severity: severe Age: children (mean 6.1 ± 4.6 years)
|
Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation |
Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.
Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitisHydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.
Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitisFor children with atopic dermatitis, a lower dose (0.7 mg/kg three times daily) can be just as effective as a higher dose (1.4 mg/kg three times daily) while causing less drowsiness.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
|
📄
Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.
|
Clinical Trial |
Total Patients: 12
Severity: severe Age: children (mean 6.1 ± 4.6 years)
|
Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation |
Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.
Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitisIs Hydroxyzine Right For Me?
-
You have itching due to allergic conditions like chronic hives or atopic dermatitis
-
You need relief from anxiety related to your skin condition
-
You are not in early pregnancy
-
You do not have a heart condition called prolonged QT interval
-
You are not allergic to hydroxyzine, cetirizine, or levocetirizine
Interested in eczema products?
As a member of the Lemma Health community, you'll stay up to date with research, hear about new products, and get exclusive access to discounts.
Personalized Eczema Care—Powered by AI
AI that understands your skin
Our AI learns from your symptoms, triggers, and lifestyle to recommend treatments tailored to you. As your skin changes, your plan adapts—for lasting relief.
Data-backed suggestions in seconds
Instantly analyzes real-world reviews and clinical research to skip months of trial and error. Get trusted, proven treatment ideas—fast.
Doctors who listen—and move fast
You’re in control. Found a treatment that resonates? We’ll connect you to a dermatologist who respects your plan and helps you get care from home.
How Lemma Health Works
Get Smart, Personalized Recommendations
Skip the guesswork
Our AI reviews thousands of research studies and real-world results to match you with the most effective treatments for your unique skin profile.
Talk to a Dermatologist who Listens — Fast
Found something you want to try?
We’ll connect you with a board-certified dermatologist who respects your preferences and helps you get what you need without the wait.
Let AI Fine-Tune Your Plan Over Time
Eczema isn’t static—
and neither is our support
As you log what’s working (or not), our AI adapts your plan to keep improving it. We help you adjust, optimize, and stay ahead of flare-ups.
Your Skin Will Thank You
Take our 2-minute profile quiz and see what’s working for people just like you.
What are others saying?
The following comments are sourced from publicly available forums, including Reddit. They reflect personal opinions and anecdotal experiences, and do not constitute medical advice. Lemma Health does not verify the accuracy, completeness, or authorship of these statements, nor does it endorse any specific treatment, medication, or outcome mentioned. These excerpts are provided for informational purposes only.
No reviews available yet
We collect reviews of treatments from various sources including social media and are not always able to verify whether these have been written by actual patients.