This study compared two different steroid creams (desonide 0.1% and betamethasone dipropionate 0.05%) for treating atopic dermatitis in children. The researchers wanted to see which cream worked better and how they affected cortisol levels in the blood.
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[Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]
[Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1 p. 100 versus betamethasone dipropionate cream 0.05 p. 100 In the treatment of childhood atopic dermatitis]
B Lebrun-Vignes, V Legrain, J Amoric, A Taïeb
Controlled Clinical Trial
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29 participants
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2000
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3 citations
Key insights related to Desonide from this study:
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What is this paper about?
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How did the authors study this?
This was a double-blind randomized trial where children were assigned to use either desonide or betamethasone cream. The creams were applied twice daily for 5 days, then once daily for 2 days, and then every other day until day 15. They measured the affected skin area and cortisol levels in the blood throughout the study.
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What populations did the authors study?
The study included 29 young children with an average age of 13.8 months who had atopic dermatitis. They were split into two groups - 15 children used desonide cream and 14 used betamethasone cream.
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What did the authors find?
Both creams were equally effective at improving skin symptoms. However, betamethasone caused a bigger drop in blood cortisol levels compared to desonide, especially during the first 5 days of treatment. The effect on cortisol levels lasted longer with betamethasone, continuing up to day 2
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What conclusions can we draw?
The researchers concluded that desonide cream 0.1% works just as well as betamethasone dipropionate cream 0.05% for treating atopic dermatitis in children, but has less impact on cortisol levels in the body. This suggests desonide might be safer while providing the same benefits.
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