Hydroxyzine Product Details

Hydroxyzine (hydroxyzine)

Available Online

Oral

Daily

Available by Prescription

As Low as $

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Highlights

Reduces itch by >85% within 2-12 hours
Itch control lasts up to 24 hours
Reduces daily symptoms by 38%
Drowsiness in 40% of patients
Higher sedation risk compared to newer antihistamines

How well does Hydroxyzine work?

Hydroxyzine is below average for atopic dermatitis "Other Non-Steroid Prescription Medication" treatments.

What is the evidence behind Hydroxyzine?

Hydroxyzine is effective at reducing itching (pruritus) in atopic dermatitis, with significant itch suppression lasting up to 24 hours after taking the medication. The best itch control (over 85% reduction) occurs between 2-12 hours after taking the medicine.

What does the research say?

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

Study Summary

Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness.

Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis

Study Type

Clinical Trial

Studied Population

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

What are other patients saying?

The medication can reduce daily symptoms of atopic dermatitis by about 38%, which is similar to other antihistamines like loratadine.

What does the research say?

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

Study Summary

Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.

Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis

Study Type

Clinical Trial

Studied Population

Total Patients: 41

Severity: not available

Age: 18-65

Results

Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

What are other patients saying?

The main side effect is drowsiness/sedation, which is more common with hydroxyzine compared to newer antihistamines. In one study, 40% of patients on hydroxyzine reported feeling sleepy, compared to only 5% on loratadine.

What does the research say?

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis	Clinical Trial	Total Patients: 41 Severity: not available Age: 18-65	Both medications reduced symptoms more than placebo, with loratadine showing better efficacy
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

Study Summary

Hydroxyzine reduced symptoms by 38% in patients with atopic dermatitis, but caused significant drowsiness in 40% of patients. The medication was as effective as loratadine but had more side effects.

Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis

Study Type

Clinical Trial

Studied Population

Total Patients: 41

Severity: not available

Age: 18-65

Results

Both medications reduced symptoms more than placebo, with loratadine showing better efficacy

Study Summary

Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis

Study Type

Clinical Trial

Studied Population

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

What are other patients saying?

For children with atopic dermatitis, a lower dose (0.7 mg/kg three times daily) can be just as effective as a higher dose (1.4 mg/kg three times daily) while causing less drowsiness.

What does the research say?

Study Summary	Study Type	Studied Population	Results
📄 Hydroxyzine effectively reduced itching in children with severe eczema, with over 85% reduction in itching from 2-12 hours after taking the medicine. A lower dose (0.7 mg/kg three times daily) was just as effective as a higher dose (1.4 mg/kg) but caused less drowsiness. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis	Clinical Trial	Total Patients: 12 Severity: severe Age: children (mean 6.1 ± 4.6 years)	Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

Study Summary

Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis

Study Type

Clinical Trial

Studied Population

Total Patients: 12

Severity: severe

Age: children (mean 6.1 ± 4.6 years)

Results

Lower dose (0.7 mg/kg) was as effective as higher dose (1.4 mg/kg) with less sedation

What are other patients saying?

Is Hydroxyzine Right For Me?

Hydroxyzine is an antihistamine medication that helps relieve itching and anxiety. It's commonly used to treat allergic conditions and can help with sleep.

Hydroxyzine might be right for you if:

You have itching due to allergic conditions like chronic hives or atopic dermatitis
You need relief from anxiety related to your skin condition
You are not in early pregnancy
You do not have a heart condition called prolonged QT interval
You are not allergic to hydroxyzine, cetirizine, or levocetirizine

Hydroxyzine works by blocking histamine, a substance in your body that causes allergic symptoms like itching. It also has calming effects on the brain, which helps reduce anxiety and promote sleep.

Hydroxyzine can be used in children. The dosage depends on the child's age: Children under 6 years can take 50 mg daily in divided doses, while children over 6 years can take 50-100 mg daily in divided doses.

Elderly patients can use hydroxyzine but should start at lower doses and be monitored closely. Older adults may be more sensitive to side effects like confusion and excessive sedation. The doctor should be careful with dosing because elderly patients often have decreased liver, kidney, or heart function.

Hydroxyzine is contraindicated (should not be used) in early pregnancy. Studies in animals have shown it can cause birth defects at doses much higher than those used in humans. There isn't enough data to confirm its safety during pregnancy in humans.

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Your journey with lemma health

Today

Discover effective treatments with board‑certified dermatologists.

Get prescriptions for immediate relief.

Within a week

Get your medications.

Design a plan for sustained relief with your personal care coordinator.

2-4 weeks

Experience less itch, reduced inflammation, better sleep, and improved wellbeing.

4–6 weeks

Review progress with your care team and fine-tune your plan.

3 months

Ensure that you have everything you need to maintain your relief.

Don't worry - your coordinator will remain available to you.

Always

Enjoy 24/7/365 access to your dedicated care team.

Today

Discover effective treatments with board‑certified dermatologists.

Get prescriptions for immediate relief.

Within a week

Get your medications.

Design a plan for sustained relief with your personal care coordinator.

2-4 weeks

Experience less itch, reduced inflammation, better sleep, and improved wellbeing.

Always

Enjoy 24/7/365 access to your dedicated care team.

3 months

Ensure that you have everything you need to maintain your relief.

Don't worry - your coordinator will remain available to you.

4–6 weeks

Review progress with your care team and fine-tune your plan.

Illustrative journey. Individual timelines and results may vary.

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