This paper compares two treatments for moderate-to-severe atopic dermatitis in young children: topical tacrolimus and mild corticosteroids. The study aimed to gather evidence about safety and effectiveness of these treatments.
-
Young children with moderate‐to‐severe atopic dermatitis can be treated safely and effectively with either topical tacrolimus or mild corticosteroids
Young children with moderate‐to‐severe atopic dermatitis can be treated safely and effectively with either topical tacrolimus or mild corticosteroids
Miia Perälä, Maria Ahola, Tytti Mikkola, Anna S Pelkonen, Anita Remitz, Mika J Mäkelä
DOI: 10.1111/apa.15001
Randomized Controlled Trial
•
75 participants
•
2020
•
5 citations
Key insights related to Protopic from this study:
- Tacrolimus is effective in treating moderate-to-severe atopic dermatitis, showing significant improvement in symptoms and disease severity compared to standard treatments like hydrocortisone.
- Tacrolimus appears to be particularly beneficial for patients who show signs of early allergic sensitization, and it can improve quality of life measures for both patients and caregivers.
-
What is this paper about?
-
How did the authors study this?
The researchers conducted a 3-year randomized open-label study, analyzing data from 75 patients after 1 year. They measured several factors including eczema severity (EASI), investigator assessment (IGA), water loss through skin (TEWL), eczema area, and blood markers (IgE and eosinophil count).
-
What populations did the authors study?
The study included children aged 1-3 years with moderate-to-severe eczema who were treated at the Skin and Allergy Hospital in Helsinki, Finland. 55% of the 75 participants were female.
-
What did the authors find?
Both treatments led to improvements in eczema symptoms and severity. However, children who showed early signs of allergies (high IgE levels, high eosinophil count, or positive allergy tests) did better with tacrolimus, showing less water loss through skin and smaller affected areas after 12 months. No serious side effects were observed with either treatment.
-
What conclusions can we draw?
The authors concluded that young children with atopic dermatitis who show early signs of allergies may benefit more from tacrolimus than from corticosteroids. They also noted that young children with moderate-to-severe atopic dermatitis may need stronger treatments that are still safe to use.
Did this article interest you?
As a member of the Lemma Health community, you'll stay up to date with research, hear about new products, and get exclusive access to discounts.
Ready for better skin health?
At Lemma Health, we provide evidence-based skin care. Access dermatologists in all 50 states. Appointments available within 3 days. Receive your medications delivered. Get ongoing 24/7/365 support. Coordinate your care across specialties.