This paper compares two treatments for atopic dermatitis in children: tacrolimus ointment (0.03%) and hydrocortisone acetate (1%). The study aimed to evaluate which treatment was more effective and safer for children with atopic dermatitis.
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Topical Tacrolimus versus Hydrocortisone on Atopic Dermatitis in Paediatric Patients: A Randomized Controlled Trial.
Topical Tacrolimus versus Hydrocortisone on Atopic Dermatitis in Paediatric Patients: A Randomized Controlled Trial.
M F Rahman, A K Nandi, S Kabir, M Kamal, M S Basher, L A Banu
Randomized Controlled Trial
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60 participants
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2015
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7 citations
Key insights related to Protopic from this study:
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What is this paper about?
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How did the authors study this?
The researchers conducted a randomized controlled trial with 60 patients. Patients were randomly split into two groups - one group received tacrolimus 0.03% twice daily, while the other received 1% hydrocortisone acetate for three weeks. They measured the effectiveness using the Eczema Area and Severity Index (EASI) score at the start and after three weeks of treatment.
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What populations did the authors study?
The study included children aged 2 to 10 years who had atopic dermatitis for at least one year. All participants met the Hanifin-Rajka criteria for atopic dermatitis diagnosis.
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What did the authors find?
Tacrolimus showed significantly better results than hydrocortisone. The tacrolimus group's EASI score decreased by 56.07%, while the hydrocortisone group's score only decreased by 27.16%. The final EASI scores were 4.86 for the tacrolimus group and 7.97 for the hydrocortisone group, showing a statistically significant difference.
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What conclusions can we draw?
The authors concluded that tacrolimus ointment (0.03%) is both effective and safe as a non-steroid treatment option for children with atopic dermatitis. It performed better than hydrocortisone in reducing the severity and extent of atopic dermatitis.
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