This study compared the effectiveness of tacrolimus (0.03% ointment) versus hydrocortisone (1% cream) in treating atopic dermatitis in children. The researchers specifically looked at how these medications affected inflammatory markers in the blood, including TARC, CTACK, TSLP, and E-selectin, as well as quality of life measures.
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Tacrolimus versus hydrocortisone in management of atopic dermatitis in children, a randomized controlled double‐blind study: New insights on TARC, CTACK, TSLP, and E‐selectin
Tacrolimus versus hydrocortisone in management of atopic dermatitis in children, a randomized controlled double‐blind study: New insights on TARC, CTACK, TSLP, and E‐selectin
Ammena Y Binsaleh, Fedaa A Kotkata, Mostafa M Bahaa, Amir O Hamouda, Mohamad A El-Gammal, Aya Ibrahim Elberri, Hend Mostafa Selim, Marwa Ahmed El-Samongy, Manal A Hamouda, Fatma A Mokhtar, Sherif Ashraf Fahmy, Thanaa A Elmasri, Eman I Elberri
DOI: 10.1002/iid3.70028
Randomized Controlled Trial
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100 participants
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2024
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0 citations
Key insights related to Protopic from this study:
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What is this paper about?
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How did the authors study this?
This was a double-blind, randomized controlled trial conducted at Tanta University from November 2022 to August 2023. 100 patients were randomly divided into two groups - one receiving tacrolimus ointment twice daily and the other receiving hydrocortisone cream twice daily for 4 months. The researchers measured blood levels of various inflammatory markers before and after treatment, and assessed quality of life using standardized scales.
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What populations did the authors study?
The study included children aged 5-16 years diagnosed with atopic dermatitis using standard criteria. They included all severity levels except very severe cases. Patients were excluded if they were on biological therapy, immune suppressing medications, anti-inflammatory drugs, or systemic steroids in the previous 4 weeks.
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What did the authors find?
Both treatments reduced inflammatory markers in the blood, but tacrolimus showed superior results compared to hydrocortisone in reducing TARC, CTACK, and TSLP levels. Both treatments similarly improved quality of life measures. Both medications also reduced levels of IL-6 and IL-10, with no significant difference between the two treatments for these markers.
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What conclusions can we draw?
The authors concluded that tacrolimus 0.03% ointment was more effective than hydrocortisone cream at reducing key inflammatory markers in children with atopic dermatitis. However, both treatments showed similar improvements in quality of life measures. The authors recommend further long-term, multi-center studies to better assess potential side effects.
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