This paper examines the safety and effectiveness of Pimecrolimus cream compared to topical corticosteroids in treating atopic dermatitis in Chinese infants. The study is a sub-group analysis of a larger study (PETITE study) focusing specifically on Chinese participants.
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Safety and efficacy of Pimecrolimus in atopic dermatitis among Chinese infants: a sub-group analysis of a five-year open-label study
Safety and efficacy of Pimecrolimus in atopic dermatitis among Chinese infants: a sub-group analysis of a five-year open-label study
Xia Dou, Lingling Liu, Xuejun Zhu, Weijing Wen, Chunya Ni, Yi Zhao, Zhixin He, Hongchun Li, Qiuning Sun, Qinping Yang, Xinfen Sun, Yifeng Guo
DOI: 10.1080/09546634.2023.2229464
Randomized Controlled Trial
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120 participants
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2023
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2 citations
Key insights related to Elidel from this study:
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What is this paper about?
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How did the authors study this?
The researchers divided infants with atopic dermatitis into two equal groups - one group received Pimecrolimus 1% cream while the other received topical corticosteroids. They tracked both safety (primary goal) and effectiveness (secondary goal) over 26 weeks.
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What populations did the authors study?
The study focused on Chinese infants between 3 months and 12 months of age with atopic dermatitis. A total of 120 infants participated, with 61 receiving Pimecrolimus and 59 receiving topical corticosteroids.
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What did the authors find?
Both treatments showed similar safety profiles with comparable rates of side effects. After 26 weeks, Pimecrolimus was successful in treating 82.9% of patients, which was similar to the success rate of topical corticosteroids at 88.5%.
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What conclusions can we draw?
The authors concluded that Pimecrolimus is both safe and effective for treating atopic dermatitis in Chinese infants. They noted that it provided sustained improvement while reducing the need for corticosteroids.
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