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Highlights
- Significant skin clearance in both adults and children
- Safe for sensitive areas like face and neck
- Reduces itching and improves symptoms
- Mild burning, stinging, or itching that improves over time
Tapinarof cream 1% applied once daily was effective in treating moderate to severe atopic dermatitis in both adults and children as young as 2 years old. In clinical trials, 45-46% of patients achieved clear or almost clear skin after 8 weeks of treatment compared to 14-18% with vehicle (placebo) cream.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
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📄
Tapinarof cream 1%, applied once daily, was effective in treating moderate to severe eczema in both adults and children as young as 2 years old. After 8 weeks, about 46% of patients using tapinarof had clear or almost clear skin, compared to only about 16% using the vehicle cream.
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Clinical Trial |
Total Patients: 813
Severity: moderate to severe Age: 2 years and older
|
Tapinarof was significantly more effective than vehicle in achieving clear or almost clear skin |
|
📄
Tapinarof cream 1% applied once daily was effective in treating moderate to severe eczema in both adults and children as young as 2 years old. After 8 weeks, about 46% of patients using tapinarof had clear or almost clear skin compared to only about 16% using placebo cream. The medication was generally safe with mostly mild side effects.
|
JournalArticle |
Total Patients: 813
Severity: moderate to severe Age: 2-81 years
|
Tapinarof cream 1%, applied once daily, was effective in treating moderate to severe eczema in both adults and children as young as 2 years old. After 8 weeks, about 46% of patients using tapinarof had clear or almost clear skin, compared to only about 16% using the vehicle cream.
Tapinarof Cream 1% Once Daily: Significant Efficacy in the Treatment of Moderate to Severe Atopic Dermatitis in Adults and Children Down to 2 Years of Age in the Pivotal Phase 3 ADORING Trials.Tapinarof cream 1% applied once daily was effective in treating moderate to severe eczema in both adults and children as young as 2 years old. After 8 weeks, about 46% of patients using tapinarof had clear or almost clear skin compared to only about 16% using placebo cream. The medication was generally safe with mostly mild side effects.
514 - Tapinarof cream 1% once daily: significant efficacy in the treatment of atopic dermatitis in two pivotal phase 3 trials in adults and children down to 2 years of age-
Vtama working magic for eczema itch
Sept. 3, 2024I've had eczema on some spots on my hands and toe a few other places for a decade+ now, constantly going in and out of flare ups. Tried steroid creams (Betamethozole, Fluocinonide) and non-steroidals (Tacrolimus) but they only seemed to work after 2+ weeks of constant 3-times-a-day applications with wrapping. They didn't really get rid of the itching until near the end of the two weeks, and within two weeks of stopping use the patches would come right back if I even itched it for 5 seconds, restarting the endless cycle. I even tried the injections in which they needle a steroid into the patch, which was faster acting but 1) hurt like hell getting it done and 2) also only lasted 2 or so weeks before issues came back. Anyway the dermatologist gave me samples of Vtama and some other one to try, and I have to say I'm shocked my Vtama. It's the only cream in which the itching stops basically immediately after I apply it to my hands or toe, like goddamn magic. This is despite me reading reviews on how it can actually cause itching, though that was for people with psoriasis I think. It did take a bit to get my skin layer thinned out back to normal, which I think helps Vtama absorb better and consistently keep the itch away everyday. Although I did cheat on occasion early on some days and apply it twice, just for the instant itch relief. Apparent the drug is expensive as hell and I just started the process of having a specialty pharmacy figure out a price, so we'll see. But as my eczema areas are smallish and not too widespread, spending a lot for a tube that will last me half a year and possibly permanently end the eczema feels like it'll be worth it. Thought I'd share.
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Latest eczema treatment options
June 12, 2024What is your experience or thoughts on some of the newer eczema treatments coming onto the market or in the process of being approved? Examples I'm thinking of are biologics, JAK inhibitors and non steroid topicals - Rinvoq, Adbry, Dupixent, VTAMA (tapinarof). The most exciting one seems to be VTAMA which is due to be approved by the FDA in Q4 2024. Seems like we have come a long way from steroid only treatment options 5 years ago. Seems like there is hope!
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Im happy but it’s not gonna last long..
Dec. 27, 2024I’m using the primecorlimus cream 1% on my cheeks and it basically vanished my contact dermatitis and red inflamed skin I had on my cheeks. I’m happy but I know like once I stop using it it might come back. So it just depressing because what even is the point and it’s not like I can use this cream forever :/
The medication provided rapid itch relief, with improvements seen as early as 24 hours after the first application. By week 8, about 31-33% of patients achieved minimal to no itch compared to 14-17% with vehicle cream.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
|
📄
Tapinarof cream 1% applied once daily showed rapid improvement in itch symptoms in patients with atopic dermatitis, with effects seen as early as 24 hours after first use. The improvement in itch continued to increase through 8 weeks of treatment.
|
JournalArticle |
Total Patients: 813
Severity: moderate to severe Age: 2 years and older
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📄
Tapinarof cream 1% applied once daily helped reduce itching and improve sleep in people with atopic dermatitis. About one-third of patients achieved minimal to no itching after 8 weeks of treatment, compared to only 14-17% of those using a placebo cream.
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JournalArticle |
Total Patients: 813
Severity: moderate to severe Age: 2 years and older
|
Tapinarof significantly improved itch compared to vehicle |
Tapinarof cream 1% applied once daily showed rapid improvement in itch symptoms in patients with atopic dermatitis, with effects seen as early as 24 hours after first use. The improvement in itch continued to increase through 8 weeks of treatment.
515 - Rapid and early onset of itch relief with tapinarof cream 1% once daily in two pivotal phase 3 trials in adults and children down to two years of age with atopic dermatitisTapinarof cream 1% applied once daily helped reduce itching and improve sleep in people with atopic dermatitis. About one-third of patients achieved minimal to no itching after 8 weeks of treatment, compared to only 14-17% of those using a placebo cream.
Achievement of No-to-minimal Itch and Sleep Improvement with Tapinarof Cream 1% Once Daily in Two Pivotal Phase 3 Trials in Adults and Children Down to 2 Years of Age with Atopic Dermatitis-
Tapinarof/VTAMA 1% cream
Aug. 7, 2024I’ve been through pretty much most steroid and non steroid creams throughout the past year. I’m on dupixent currently and my derm prescribed me Tapinarof to help with facial flares since dupixent isn’t really helping in that area at all. Anyone have experience with this cream and any positives/negatives? I did some research and it seems fairly new so not much history posted on Reddit yet.
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Need help with mouth
Nov. 10, 2024Hi, I’ve been struggling with eczema for all my life, but around a few years ago, the skin around my mouth has become thickened into like a crust and dry skin and it has really irritated me, something like angular cheilitis. I’ve been going from doctor to doctor about possible treatments and none of them worked. I’ve tried dupixent, steroids, prescribed creams like opzelura and vtama. I also use aquaphor daily. None of them worked. They’ve checked for my skin to see if there was a fungal infection but there wasn’t. Is there anything that has worked for you guys on this issue?
Tapinarof was well-tolerated across all age groups and skin types. The most common side effects were mild to moderate and included folliculitis (hair follicle inflammation), headache, and nasopharyngitis (common cold). Very few patients (less than 2%) had to stop treatment due to side effects.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
|
📄
Tapinarof cream 1% applied once daily was effective in treating moderate to severe eczema in both adults and children as young as 2 years old. After 8 weeks, about 46% of patients using tapinarof had clear or almost clear skin compared to only about 16% using placebo cream. The medication was generally safe with mostly mild side effects.
|
JournalArticle |
Total Patients: 813
Severity: moderate to severe Age: 2-81 years
|
|
|
📄
Tapinarof cream 1% was tested for skin safety in healthy adults. The cream was found to be safe, causing only very mild skin irritation, and did not cause allergic reactions or increased sensitivity to sunlight.
|
Clinical Trial |
Total Patients: 376
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This was a safety study, not an efficacy study |
Tapinarof cream 1% applied once daily was effective in treating moderate to severe eczema in both adults and children as young as 2 years old. After 8 weeks, about 46% of patients using tapinarof had clear or almost clear skin compared to only about 16% using placebo cream. The medication was generally safe with mostly mild side effects.
514 - Tapinarof cream 1% once daily: significant efficacy in the treatment of atopic dermatitis in two pivotal phase 3 trials in adults and children down to 2 years of ageTapinarof cream 1% was tested for skin safety in healthy adults. The cream was found to be safe, causing only very mild skin irritation, and did not cause allergic reactions or increased sensitivity to sunlight.
Dermal Safety of Tapinarof Cream 1%: Results From 4 Phase 1 Trials.-
Vtama?
Oct. 31, 2023Has anyone else been prescribed vtama? I was just prescribed it by my derm and was wondering if anyone has any experiences with it. I know it’s fairly new but I haven’t seen a lot of talk about it so I’m curious.
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Nummular eczema
June 23, 2024Hey guys, so I recently got diagnosed with nummular eczema. I had a big spot on the side of my foot which I got the biopsy. I started to get some in between my legs and then spread to my stomach as well as breasts and back. I’ve became really insecure. I’ve been using vtama which has helped also moisturizing with Larosche posay. Any tips on how to deal with flare ups? Also is it normal to get the eczema on my private area that itches?
The medication worked consistently well across all racial groups and skin types, including patients with darker skin tones who made up about 50% of the study participants.
| Study Summary | Study Type | Studied Population | Results |
|---|---|---|---|
|
📄
Tapinarof cream 1% applied once daily was effective in treating atopic dermatitis across all skin colors and races in both adults and children as young as 2 years old. The medication worked significantly better than the vehicle (cream without active ingredient) in clearing or almost clearing eczema symptoms.
|
JournalArticle |
Total Patients: 813
Severity: moderate to severe Age: 2 years and older
|
Tapinarof was significantly more effective than vehicle in achieving clear or almost clear skin across all racial groups |
|
📄
Tapinarof cream 1% applied once daily was effective in treating atopic dermatitis across all skin colors and races, including children as young as 2 years old. About 40-50% of patients achieved clear or almost clear skin after 8 weeks of treatment, which was significantly better than the placebo group.
|
JournalArticle |
Total Patients: 813
Severity: moderate to severe Age: 2 years+
|
Tapinarof showed significantly higher rates of clear/almost clear skin compared to vehicle across all populations |
Tapinarof cream 1% applied once daily was effective in treating atopic dermatitis across all skin colors and races in both adults and children as young as 2 years old. The medication worked significantly better than the vehicle (cream without active ingredient) in clearing or almost clearing eczema symptoms.
Tapinarof Cream 1% Once Daily is Efficacious for the Treatment of Atopic Dermatitis in Patients with Skin of Color Down to 2 Years of Age in Two Pivotal Phase 3 TrialsTapinarof cream 1% applied once daily was effective in treating atopic dermatitis across all skin colors and races, including children as young as 2 years old. About 40-50% of patients achieved clear or almost clear skin after 8 weeks of treatment, which was significantly better than the placebo group.
670 - Tapinarof cream 1% once daily is efficacious for the treatment of atopic dermatitis in patients with skin of color down to 2 years of age in two pivotal phase 3 trials-
Starting VTAMA cream
Jan. 10, 2025Finally received VTAMA from my doctor, I will update and let you all know if it helps over the next couple weeks/months. My doctor sent the prescription to a "specialty pharmacy" in town that only cost me $35 due to a manufacturer discount/coupon. Otherwise the price with my insurance at CVS was over $1K for one tube of it.
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Eczema and maple tree allergy
May 13, 2024So my son, who is 3, has had a severe case of eczema since he was 9 months old. We’ve gone through allergy testing, and staying clear from his allergens, plus a shot of dupixent every 4 weeks, and Vtama daily has cleared his skin to what I consider 90% (he still has some patches but we celebrate what small wins we have). I have a weird question. He’s allergic to maple trees. Would he also be allergic to maple syrup? His allergist said probably not, but he (my son) has a pretty severe sunflower seed allergy that we deal with daily (apparently sunflower seed oil is in a LOT of products). His skin has been clear from flare ups for 2 months now and I don’t want another to happen. I just wanted to see if anyone else has had a maple allergy that has made their eczema flare.
Is Vtama Right For Me?
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You are 2 years of age or older
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You have atopic dermatitis
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You can use it with or without other treatments
Interested in eczema products?
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Discover effective treatments with board‑certified dermatologists.
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Ensure that you have everything you need to maintain your relief.
Don't worry - your coordinator will remain available to you.
Enjoy 24/7/365 access to your dedicated care team.
Discover effective treatments with board‑certified dermatologists.
Get prescriptions for immediate relief.
Get your medications.
Design a plan for sustained relief with your personal care coordinator.
Experience less itch, reduced inflammation, better sleep, and improved wellbeing.
Enjoy 24/7/365 access to your dedicated care team.
Ensure that you have everything you need to maintain your relief.
Don't worry - your coordinator will remain available to you.
Review progress with your care team and fine-tune your plan.
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What are other patients saying?
It's the only cream in which the itching stops basically immediately after I apply it to my hands or toe, like goddamn magic.
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