Hydrocortisone cream (hydrocortisone)
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  • Effective in 65-75% of patients for reducing itching, redness and scaling
  • Safe for children as young as 3 months old
  • Available in multiple formulations (cream, lotion, ointment)
  • Mild burning sensation in 2-4% of patients, usually temporary
How well does Hydrocortisone cream work?
Hydrocortisone cream is below average for atopic dermatitis "Steroids" treatments.
What is the evidence behind Hydrocortisone cream?
Topical corticosteroids are effective as a first-line treatment for atopic dermatitis, with studies showing significant improvement in symptoms within weeks of proper use
What does the research say?
Study Summary

A spray form of the steroid desoximetasone was tested in adults with atopic dermatitis. The spray significantly reduced itch and improved symptoms within 1 week, and these improvements lasted throughout the 4-week study. No side effects were reported.

Efficacy and Safety of Desoximetasone 0.25% Spray in Adult Atopic Dermatitis Subjects: Pilot Study.
Study Type
Clinical Trial
Studied Population
Severity: not available
Age: 18+
Results
Skin appearance improved within 1 week and stayed better for 4 weeks

Study Summary

Using a strong steroid cream (fluticasone) worked better than a mild steroid cream (hydrocortisone) for treating moderate eczema flare-ups in children. Children using the stronger steroid had better symptom improvement and quality of life over 24 weeks.

Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial
Study Type
Randomized Controlled Trial
Studied Population
Total Patients: 32
Severity: moderate
Age: 3 months-17 years
Results
Strong steroid showed significantly better symptom control throughout the study period

Study Summary

The study compared two ways of applying steroid cream in children with eczema - either on wet skin after a bath (soak and smear) or on dry skin. Both methods worked equally well, improving eczema by about 80-85%.

A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD).
Study Type
Randomized Controlled Trial
Studied Population
Total Patients: 45
Severity: not available
Age: children (specific range not available)
Results
Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

What are other patients saying?
  • TSW is rare. Please use steroids.
    Dec. 7, 2023
    Edit: Take this as a grain of salt please. You may have had TSW, you may have not. I don't need people calling me an idiot for saying TSW is rare. In this sub we see so many people scared to death that using hydrocortisone once will result in TSW. It won't. Hydrocortisone would have to be used for years upon years on very thin skin to even effect you in the slightest. Steroids are the first line treatment for a reason, and you don't need to be scared to use them. To get TSW you've gotta been using something like mometasome (elocon) or clobestol (Dermovate) for years, consistently. Even then, TSW isn't fully understood by dermatologists. If your eczema flares up after taking a steroid or applying a steroid, you probably still have a flare with active eczema, and you need to control it. Avoiding steroids does nothing but cause you harm. TSW isn't even fully understood yet. Yes it's definitely a thing, but we don't understand the root causes of it. The fearmongering (kinda) on this sub over steroids is criminal. They aren't dangerous. They are the best option for eczema. This is all coming from someone who has had active, severe eczema for 3 years. I don't have TSW, and I use steroids frequently. At the end of the day, you are probably fine. Keep using your steroid as directed by the doctor, and wean off them if you've been on it a while. Rant over ❤️
  • Hydrocortisone on the face
    June 18, 2024
    I use hydrocortisone lotion on my face to manage flare ups that come every couple of weeks. I use it as prescribed which is twice a day for a week. After three days it’s calmed a lot. The internet has stigmatised steroid creams as dangerous which I hate. Because of that I stopped using steroid creams for my eczema which was hydrocortisone and lucoid for about two and a half months. IT WAS ABSOLUTE HELL! I know TSW is real but I feel like if steroid creams do work for people who suffer with eczema then why not keep using? I would rather live a comfortable life then living with pain mentally and physically. I just want some reassurance I guess. I only use it when I need to and not for long periods of time.
  • Hydrocortisone
    Aug. 22, 2023
    I put hydrocortisone on my face as I had a bad flare. I already have thin skin by I’m afraid that there will be a rebound. Could anyone please share their experience with topical steriods and how they’re able to manage it without these rebounds??
Potent (stronger) topical corticosteroids may be more effective than mild ones for moderate flare-ups, showing better symptom improvement and quality of life scores over 24 weeks
What does the research say?
Study Summary

Using a strong steroid cream (fluticasone) worked better than a mild steroid cream (hydrocortisone) for treating moderate eczema flare-ups in children. Children using the stronger steroid had better symptom improvement and quality of life over 24 weeks.

Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial
Study Type
Randomized Controlled Trial
Studied Population
Total Patients: 32
Severity: moderate
Age: 3 months-17 years
Results
Strong steroid showed significantly better symptom control throughout the study period

What are other patients saying?
  • How many more f*ing drugs do they want me on?
    Nov. 30, 2023
    tag is rant/humor/meme, but this isn't meme or funny. Let's review what these sick fuck derms have put me through my whole life. OH, RASH? EASY FIX: Hydrocortisone - fail. OH DON'T WORRY, BEST DRUG: Alclometasone (Aclovate) - fail. WAIT, STRONGER, WILL FIX: Fluticasone propionate (Cutivate) - fail. EVEN STRONGER, WON'T NEED MORE: Betamethasone dipropionate (Diprolene) - fail. STRONGER STILL, GUARANTEED CLEAR: Desoximetasone (Topicort) - fail. NON-STEROIDAL WONDER DRUG: Tacrolimus (Protopic) - fail. MOAR NON-STEROIDAL WONDER DRUG: Pimecrolimus (Elidel) - fail. HOT NEW SH!T NON-STEROIDAL INTERLEUKIN WILL CHANGE YOUR LIFE: Dupilumab (Dupixent) - fail. OH WAIT NOW WE GOT THAT NEW NEW NEW NEW FOR YOU IT'LL SOLVE EVERYTHING FOREVER: Upadacitinib (Rinvoq) - next step. Forgive me for not believing you sick fucks for creating this addiction in my life, forgive me for finding you to be utterly disgusting for denying the existence of severe side effects and withdrawals from all of these drugs. Forgive me for not believing your next fucking drug is going to solve anything. Allergist found my allergy to dust mites and mold. Food allergy test is next. I'm done looking at these fuckfaces and thinking they have my best interests at heart. Elimination diet, and moving somewhere with less dust mites and mold, is next step.
  • My allergist said to not worry about using steroids
    May 2, 2024
    So my allergist prescribed me a 0.1% triamcinalone ointment for below face and 2.5% hydrocortisone for face. He said to use it 2 times a day 1 week on and 1 week off. Will this cause topical steroid withdrawal? What do you guys think?
  • doctors not listening
    Aug. 2, 2024
    i’ve been to the doctors today for multiple reasons, one being my skin. when discussing treatments with the doctor, i mentioned how i don’t want to use any more topical steroids since they don’t work to fix the root cause and only work for the time they’re used. i also said how i don’t want to use them since they cause more issues in the long run such as thinned skin and tsw. the doctor basically told me to not listen to people online or google, and steroids are fine to use. also when telling him i didn’t want to use them, he said there’s nothing else he can do to help me if i’m not willing to accept the use of steroids. i know it’s their job to hand out help with the resources they have available and as general practitioners they don’t actually specialise in skin specifically, but i do think with eczema being as common as it is, more research should be done on steroids and other treatments by doctors. however, he has referred me to get blood tests so hopefully this is a step in the right direction.
The method of applying topical steroids (whether to wet or dry skin) does not significantly affect treatment outcomes, suggesting flexibility in application methods
What does the research say?
Study Summary

The study compared two ways of applying steroid cream in children with eczema - either on wet skin after a bath (soak and smear) or on dry skin. Both methods worked equally well, improving eczema by about 80-85%.

A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD).
Study Type
Randomized Controlled Trial
Studied Population
Total Patients: 45
Severity: not available
Age: children (specific range not available)
Results
Both methods of applying topical corticosteroids (wet vs. dry skin) showed similar effectiveness

What are other patients saying?
  • How to properly use hydrocortisone?
    Aug. 17, 2023
    Okay, so first of all I'm not a doctor nor an expert. But this doctor visit, where I was told how to properly use hydrocortisone changed my skin so much in such a quick time, that I need to share if someone is struggling. Because I couldn't find it on the internet or elsewhere. 1. Do your skincare as you would normally do, hydrate a little more than usual and apply hydrocortisone only on places where eczema is showing (as a last step in your skincare). 2. 7/3 rule. Use for seven days, then put it aside for three and then you can start again for another seven days... It's so you don't create dependency on it! In the end it's really simple, but I couldn't find if I should do my skincare before or just apply it on a dry skin. I hope it will help someone! And if everyone knows about it, then I'm happy too!
  • FINALLY GOING ON DUPIXENT
    Jan. 6, 2025
    i've told my story a few times in comments here, but worth sharing as a post. i've had eczema for my entire life (f20) and it had gotten so bad as a child that i developed staph OSSA, which went unnoticed until it turned into septic osteomyelitis. it was originally thought that i had several allergies (was diagnosed with 20+) and had been on immunotherapy shots from ages 7-13. these cleared my skin tremendously and even for the 7 years after... until this year. i had been having on and off eczema flares since january, what i originally thought were hives. these didnt look like my normal eczema flares. it was manageable with benadryl and my usual lotions, until overnight it got a million times worse. in august, my eczema was covering the backs of my legs completely, what still looked like hives. then it spread to my arms, my stomach, my chest, my back, and my scalp. i was miserable, barely sleeping from itching and the fear of getting another infection. at first i thought i had idiopathic urticaria due to the nature of the eczema. then, i thought it was duhrings disease (i have celiac and live with 7 other girls, none of whom are celiac, so i thought it was cross contamination). it turns out that my issue is just hot water. every time i shower or bathe, i break out and the eczema doesn't go away. in october, i went to my doctors who prescribed me prednisone and a low dosage TS, and it went away for the week i took it. since it was a weeks dose, it meant i couldn't taper off. my skin suddenly was thick, scaly red all up and down my arms the minute i went off of it. i went to my doctors in tears, as i was losing all self confidence, the ability to sleep, the ability to focus at school, and the ability to be around friends without sickening jealousy. i completely isolated myself these few months. i was prescribed another topical steroid, which cleared my skin nearly instantly. i was prescribed it for 21 days -- nobody would've known i was suffering this skin condition if i hadn't told them. during these 21 days, i managed to get into a relationship with the most amazing man ever. but after the 21 days in november, my skin was getting itchier by the moment. i went to my dermatologist, who said my eczema was spreading over 80% of my body -- she prescribed me more prednisone, clobetasol, hydrocortisone for my face (which was now flaring up and hadn't before) as well as zyrtec and singulair to help with itching. these worked mostly, but i found that clobetasol wasn't working as well as i thought it would. i soon went to the allergist who wrote me a prescription for dupixent. i learned that dupixent would be my only option, as my previous history with severe infections would make taking JAK inhibitors insanely risky. but, insurance denied my dupixent request. i was put on protopic, a non-steroid topical, and my skin broke out into small bumps, what seemed to look like razor burn. they didn't itch whatsoever, but still this made me absolutely miserable. i was scared to use hot water to shower and risk a flare, knowing how bad it was a few months ago. i've been exhausted throughout all of this, looking for answers and battling the depression that came with it. i stopped using the protopic, which helped clear my skin, and started taking the zyrtec and singulair (which i didn't take when prescribed since i thought that was silly), and my skin is a bit itchy but not breaking out into flares anymore. but FINALLY, after my last checkup with my allergist (who said that i've done absolutely everything i possibly could've to treat this), i FINALLY GOT APPROVED FOR DUPIXENT. i will update on this with how it works for me once i get it, but i'm extremely hopeful.
  • Hydrocortisone on the Eyelids?
    Dec. 7, 2015
    Basically I'm sick of heading to my GP and I soon as I say the word "eczema" they send me on my way with a bottle of emollient and some kind of steroid. My eczema gets me down a lot and I want to hear from people in my situation! My flareups are pretty bad in the usual places, but the worse bits are on my face and neck, especially my eyelids and behind my eyes. My eyes get incredibly itchy and flakey and I get so self conscious about it! I once forgot my creams whilst away for a job interview at Dolby Audio and was so self-conscious about my horrid flakey red face that I just totally ballsed up the interview :( I buy myself Aveeno as a moisturiser, which I find great, E45 Anti Itch Cream and use 1% hydrocortisone. Everyone knows about the whole "skin thinning" business, but it's the only thing that works for me after years and years of searching. I usually put a tiny a bit of hydrocortisone on my eyelids 2 days out of 3 and have been doing for a few years now. Am I putting myself at risk here? Any advice would be great, I don't want my skin to go to shit any more than it already has!
Is Hydrocortisone cream Right For Me?
What is Hydrocortisone cream?
Hydrocortisone is a topical steroid cream that you apply directly to your skin. It belongs to a class of medications called corticosteroids, which help reduce inflammation and itching.
What are the requirements for taking Hydrocortisone cream?
Hydrocortisone cream might be right for you if:
  • You are 2 years or older

  • You have itching from skin conditions like eczema, psoriasis, or seborrheic dermatitis

  • You have itching from insect bites

  • You have skin reactions to products like soaps, detergents, jewelry, or cosmetics

  • You have itching from poison ivy, oak, or sumac

How does Hydrocortisone cream work?
Hydrocortisone works by reducing inflammation in your skin. It decreases the release of substances in the body that cause inflammation, redness, and itching.
Is it safe for children?
Do not use on children under 2 years of age without consulting a doctor. For children 2 years and older, it can be used up to 3-4 times daily. For anal and genital itching, children under 12 should consult a doctor.
Is it safe for elderly patients?
Hydrocortisone is generally safe for elderly patients. However, older adults may be more sensitive to its effects and should use it with caution, especially on thin skin areas.
Is it safe during pregnancy?
While hydrocortisone is generally considered safe during pregnancy when used in small amounts on limited areas of skin, you should consult your healthcare provider before using it while pregnant.
Is it safe during breastfeeding?
Hydrocortisone cream is generally considered safe during breastfeeding when used in small amounts on limited areas of skin. However, avoid applying it to the breast area before nursing.