

Highlights
- Reduces itching within first few days
- 31-33% achieve clear/almost clear skin in 4 weeks
- Safe for long-term use up to 48 weeks
- 71% symptom improvement in adolescents
- Mild application site reactions (pain, irritation)
Crisaborole is effective for treating mild-to-moderate atopic dermatitis in both children and adults, with significantly more patients achieving clear/almost clear skin compared to vehicle (placebo) treatment
Study Summary | Study Type | Studied Population | Results |
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Crisaborole 2% ointment is effective for treating mild to moderate atopic dermatitis in patients aged 2 years and older. The medication works by reducing inflammation and itching, with about 30-50% of patients achieving clear or almost clear skin after 4 weeks of treatment.
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Severity: mild to moderate Age: 2 years and older
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Crisaborole showed better efficacy than vehicle in achieving clear or almost clear skin | |
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Crisaborole ointment was more effective than placebo in treating mild to moderate eczema in patients aged 2 years and older. About 32% of patients using crisaborole achieved clear or almost clear skin compared to 18-25% using placebo, and the medication showed a good safety profile.
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Clinical Trial |
Severity: mild to moderate Age: 2 years and older
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Significantly more patients using crisaborole achieved clear/almost clear skin with ≥2-grade improvement compared to vehicle |
Crisaborole 2% ointment is effective for treating mild to moderate atopic dermatitis in patients aged 2 years and older. The medication works by reducing inflammation and itching, with about 30-50% of patients achieving clear or almost clear skin after 4 weeks of treatment.
Efficacy and Safety of Crisaborole Ointment, a Novel, Nonsteroidal Phosphodiesterase 4 (PDE4) Inhibitor for the Topical Treatment of Atopic Dermatitis (AD) in Children and AdultsCrisaborole ointment was more effective than placebo in treating mild to moderate eczema in patients aged 2 years and older. About 32% of patients using crisaborole achieved clear or almost clear skin compared to 18-25% using placebo, and the medication showed a good safety profile.
Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults.-
Magic cure?
Jan. 7, 2024So about 3 months ago my cousin suggested I start taking the OTC supplement NAC. He said it cured his eczema on his hands. I thought “what the hell” and gave it a whirl. Ok, this stuff is magic. I haven’t had a flare up yet, haven’t had to use any Eucrisa or steroids, and — for the first time I remember in my adult life— I can wash dishes without gloves! Has anyone else tried it?
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Has anyone tried Eucrisa?
April 7, 2024I have pretty severe hand eczema. I have for over 30 years. Went to the doc recently after a flare up and told the doc I didn’t want steroid cream. He prescribed Eucrisa. Does anyone have any experience with this? I’m under the impression it’s a relatively new drug on the market here (Canada).
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Anyone has luck w Eucrisa on face?
Sept. 6, 2022I’m getting eucrisa tomorrow for the eczema between my nose and mouth. Has anyone else had any luck? What is your experience with it?
The most common side effect is application site pain/discomfort, occurring in about 4-6% of patients. Most side effects are mild to moderate and treatment-related adverse events are infrequent
Study Summary | Study Type | Studied Population | Results |
---|---|---|---|
📄
Crisaborole 2% ointment is effective for treating mild to moderate atopic dermatitis in patients aged 2 years and older. The medication works by reducing inflammation and itching, with about 30-50% of patients achieving clear or almost clear skin after 4 weeks of treatment.
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Severity: mild to moderate Age: 2 years and older
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Crisaborole showed better efficacy than vehicle in achieving clear or almost clear skin | |
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Crisaborole ointment was tested in infants aged 3-24 months with mild-to-moderate eczema. The treatment was well-tolerated with mostly mild side effects, and about 30% of patients achieved clear or almost clear skin after 28 days of treatment.
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Clinical Trial |
Total Patients: 137
Severity: mild to moderate Age: 3-24 months
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Crisaborole 2% ointment is effective for treating mild to moderate atopic dermatitis in patients aged 2 years and older. The medication works by reducing inflammation and itching, with about 30-50% of patients achieving clear or almost clear skin after 4 weeks of treatment.
Efficacy and Safety of Crisaborole Ointment, a Novel, Nonsteroidal Phosphodiesterase 4 (PDE4) Inhibitor for the Topical Treatment of Atopic Dermatitis (AD) in Children and AdultsCrisaborole ointment was tested in infants aged 3-24 months with mild-to-moderate eczema. The treatment was well-tolerated with mostly mild side effects, and about 30% of patients achieved clear or almost clear skin after 28 days of treatment.
Safety, Effectiveness, and Pharmacokinetics of Crisaborole in Infants Aged 3 to < 24 Months with Mild-to-Moderate Atopic Dermatitis: A Phase IV Open-Label Study (CrisADe CARE 1)-
BIG WIN (hopefully!)
July 19, 2024SO. i’ve posted a few times about how ive been dealing with a really bad flare up, and im finally having something done about it. first up, doctor gave me some allergy pills, rupatadine (rupall brand name) and BOY do those help my itch. second, also got prescribed eucrisa. it’s a non steroid treatment cream which ive been using for about 5 or 6 days and have noticed MASSIVE improvement where ive been applying on my arms and legs. have not had any burning or any negative side effects thus far. third, eucerin eczema flare up treatment + 0.5% hydrocortisone on my breasts = big improvement. fourth, i’m seeing an allergist next week. fifth, im seeing a dermatologist in october (thx canada) i finally feel hope. for so many months of hating myself because of this condition, im finally gaining back my confidence. i know ive got a long journey ahead of me and that this is a lifelong battle but ive finally got HOPE. there will be wins and losses and redness and itchiness and smoothness and expensive skincare regimes, but i will get through this and i will continue fighting it. in the grand scheme of things it’s such an almost pathetic condition, but it’s also so debilitating. both physically and mentally. to those of you who are feeling like you’re losing hope and want to give up, DONT. you will find what works for you. it may take weeks or months or years but you will find your treatment. ❤️❤️❤️❤️
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Eucrisa was working wonders. Now it stopped working almost entirely
Nov. 12, 2024So, I had minor eczema on my eyelids, which I started getting around 2018 or 2019, which was perfect timing because Eucrisa had just come out (in Canada). I got half a dozen free samples, which lasted me 4ish years. I only used it to treat flair-ups, and typically, after a few weeks, things would be looking good. During this past summer, while on my last tube, I noticed that I was using more of it, and my eczema flair-up was spreading and not going away. Usually, it was just my eyelid, but now it's reaching towards my temple, into the bridge of my nose, and my eyebrows. It was coming close to the expiry date, so I chalked it up to that, but I went to my pharmacy, got a fresh full tube, and it's still the same. My eczema seems to be getting worse now, and the Eucrisa only gives me temporary relief for an hour or two before I start getting itchy and dry again. Anyways, I was hoping someone may have gone through the same thing here, and if they have any anecdotal stories or advice they can offer while I wait to see my doctor again. Thanks
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How long do you leave Eucrisa on?
Dec. 22, 2021I’m having the worst flare I’ve had in some time - patches on my face and my neck to collar bone is almost completely covered. I’ve been able to manage facial / neck eczema with Eucrisa in the past so I’ve filled my script and I can deal with the burning but I HATE feeling covered in petroleum jelly all day. I absolutely cannot stand feeling sticky and finding my hair caught in it; I’d never put up with this if the itching and pain from the eczema wasn’t so bad right now. My derm said to leave it on but curious if anyone has still had results with Eucrisa if they wipe it off a while after application? I guess what I wish I knew is whether all the active ingredient has absorbed into my skin after an hour or two and I’d be ok to wipe the awful jelly off my skin at that point without diminishing effectiveness of the medication. I don’t mind feeling sticky a few hours a day but it feels like adding insult to injury when I’m still itchy and painful at this point AND I have to be sticky 24/7. Would love to know if anyone has any experience with this!
Crisaborole can be used as a long-term maintenance treatment, with studies showing sustained efficacy and safety over 48-52 weeks of use
Study Summary | Study Type | Studied Population | Results |
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Once-daily crisaborole ointment was tested as a long-term maintenance treatment for mild-to-moderate eczema. Patients using crisaborole stayed flare-free for longer (111 days vs 30 days) compared to those using a placebo ointment, and had fewer flares over the course of a year.
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Clinical Trial |
Total Patients: 497
Severity: mild to moderate Age: ≥3 months
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Once-daily crisaborole ointment helped prevent eczema flares for longer compared to vehicle (placebo), with patients staying flare-free for about 111 days versus 30 days. Patients using crisaborole had fewer flares overall and more flare-free days during the year-long study.
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Total Patients: 270
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Crisaborole significantly delayed time to first flare compared to vehicle |
Once-daily crisaborole ointment was tested as a long-term maintenance treatment for mild-to-moderate eczema. Patients using crisaborole stayed flare-free for longer (111 days vs 30 days) compared to those using a placebo ointment, and had fewer flares over the course of a year.
Once-Daily Crisaborole Ointment, 2%, as a Long-Term Maintenance Treatment in Patients Aged ≥ 3 Months with Mild-to-Moderate Atopic Dermatitis: A 52-Week Clinical StudyOnce-daily crisaborole ointment helped prevent eczema flares for longer compared to vehicle (placebo), with patients staying flare-free for about 111 days versus 30 days. Patients using crisaborole had fewer flares overall and more flare-free days during the year-long study.
288 Once-daily crisaborole as a long-term maintenance treatment in patients with mild-to-moderate atopic dermatitis: A 52-week clinical trial-
Experience with Eucrisa.
May 27, 2017This post is about my experience using Eucrisa so far for people who have or been thinking about getting a prescription for it. So a couple weeks after Dupixent / Dupilumab came out, I went to my dermatologist to see about getting a prescription for it. She was hesitant to give it to me since 1) it's internal, 2) the long-term effects aren't known, 3) she hasn't gotten to visit with a rep yet, and 4) my eczema isn't debilitating, so she wanted to try a "smaller gun" before bringing out the "big guns." First, though, she wanted to clear my current flare, so I went on a two-week round of oral steroids with topical steroids to match. After that, I was cleared up pretty good, and got my prescription for Eucrisa. I started it about a week after finishing my steroids, because my regular pharmacy (Walmart, if you're curious) doesn't have it on hand and had to order it special. You might want to let your derm know that so you make sure to get your meds on time! So I've been on it for about two weeks now, and I'm pretty happy with it! The instructions say to put it on every day, but I've been doing every other day and smearing it on with the rest of my lotion. I had a patch on my hand that went back to flaring after I got off the Prednisone, and the Eucrisa cleared it up! It's even getting back to looking like healthy skin rather than having that steroid shiney-ness. I haven't tried eating dairy products (huge trigger for my eczema!) on the Eucrisa yet, but I want to to see if it can keep my flares under control while I indulge. Anyway, I hope this was helpful. I haven't seen a whole lot of posts here about it, so I thought I'd share my experience. If anyone has questions, I'm happy to answer! EDIT: Thank y'all for commenting your experiences with Eucrisa! I know how discouraging it is to start in on a really niche, specific journey and not be able to find advice or insight about it online. So I'm glad we could amass some anecdotes about Eucrisa for people who will use it in the future!
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Dyshidrotic Eczema / Pompholyx & Scrotal Dermatitis - Eucrisa
Jan. 24, 2018Hello, I wanted to share that I have been having success in the management of dyshidrotic eczema on hands / feet with the new cream Eucrisa. After perhaps 5 years of being more or less symptom free, I went into an intense flare up of dyshidrosis on my hands, with some symptoms on my feet. I also suffered from scrotal dermatitis at this time. I went to a new dermatologist in my area as my old one had retired. Formerly (five years ago), I had been receiving an occasional intramuscular kenalog shot to manage my symptoms. My new doctor was not comfortable with this treatment and initially prescribed clobetasol cream. The clobetasol had no effect whatsoever it seemed. I subsequently received direct injections of kenalog into the lesions on my hands and feet, which would clear up the eczema for a week or so. This requires getting a couple dozen injections into my hands and feet every month for about a week of relief - a bit painful, tedious, and not terribly effective. My doctor then mentioned Eucrisa but felt clobetasol would be more effective. He suggested I do two applications of clobetasol and two applications of Eucrisa for a total of four daily applications. THIS DID NOT WORK. For some reason, when also using the clobetasol I did not have success, so I thought little of Eucrisa for some time. Eventually, out of desperation and fear of what clobetasol might eventually start doing to my skin in terms of damage, I started applying Eucrisa twice a day by itself, morning and night, without also using clobetasol. The results were hard to believe - in short order it cleared my eczema up dramatically and greatly improved my quality of life. Initially, I would apply Eucrisa morning and night under occlusion - under rubber gloves for a couple hours each application. This helped me to still operate in practical terms without smearing the ointment on everything I touched (Eucrisa does not absorb nearly as quickly as say Elidel). In time, as my symptoms improved, I found that two 20-minute applications each day, once in the morning and once at night, without gloves also effectively managed my symptoms. But I suggest starting out with longer applications if possible. I also used twice daily applications of Eucrisa for my scrotal dermatitis and found it to have a similarly dramatic positive effect, clearing my symptoms in a matter of days. I suggest using for some time after your symptoms clear for best / continued results for both dyshidrosis and scrotal dermatitis. I have also been using Cerave daily moisturizing lotion for my hands. While not a cure into itself of course I find it helped to heal my hands quickly and keep the skin in good condition. It is not greasy and absorbs very quickly - good stuff. I wanted to share in hopes that others may also find relief from these challenging conditions. Eczema can be very difficult and demoralizing but I do believe that different people respond to different treatments and that with persistent experimentation you can find treatment options that work for you. I also believe that for me stress is a factor in eczema flares - both work related and personal so try to minimize stressful situations and manage how you respond to them as best you can. As regards expense, with insurance Eucrisa is about $35 - $40 for a 60mg tube. If your insurance does not cover or if you do not have insurance, there is a savings program that you can investigate your eligibility for here: https://www.eucrisa.com/eucrisa-4-you Stay positive and best of luck!
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Applying Eucrisa is fun
Oct. 15, 2021Got approved for a Eucrisa prescription a week ago and it's already helping some stubborn old patches heal. I still scratch, but it's because I don't apply twice a day. My skin is soft and looks less inflamed. I'm a lot less stressed about my skin now because there's something that actually helps with the itching, and isn't going to damage my skin long term. As I float off to sleep, I can feel my eczema patches tingle as they get neutralized. It is a great feeling. When I put it on my skin, I pretty much marvel about how I've had to apply less compared to when I first started using it. I wish I had heard about Eucrisa and biologicals in general sooner.
The medication works quickly, with improvements in itch and skin symptoms seen within the first week of treatment in many patients
Study Summary | Study Type | Studied Population | Results |
---|---|---|---|
📄
Crisaborole 2% ointment is effective for treating mild to moderate atopic dermatitis in patients aged 2 years and older. The medication works by reducing inflammation and itching, with about 30-50% of patients achieving clear or almost clear skin after 4 weeks of treatment.
|
Clinical Trial |
Severity: mild to moderate Age: 2 years and older
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Crisaborole showed better efficacy than vehicle in achieving clear or almost clear skin |
📄
Crisaborole ointment 2% was more effective than placebo in treating mild-to-moderate eczema in children and teenagers. Patients using crisaborole showed faster and greater improvements in both skin appearance and itch compared to those using vehicle (placebo), with benefits seen as early as 8 days after starting treatment.
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Randomized Controlled Trial |
Severity: mild to moderate Age: 2-17 years
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Significantly greater improvement in ISGA scores for crisaborole vs vehicle, particularly in patients with moderate baseline disease |
Crisaborole 2% ointment is effective for treating mild to moderate atopic dermatitis in patients aged 2 years and older. The medication works by reducing inflammation and itching, with about 30-50% of patients achieving clear or almost clear skin after 4 weeks of treatment.
Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor.Crisaborole ointment 2% was more effective than placebo in treating mild-to-moderate eczema in children and teenagers. Patients using crisaborole showed faster and greater improvements in both skin appearance and itch compared to those using vehicle (placebo), with benefits seen as early as 8 days after starting treatment.
Improvement in disease severity and pruritus outcomes with crisaborole ointment, 2%, by baseline atopic dermatitis severity in children and adolescents with mild‐to‐moderate atopic dermatitis-
Eucrisa is a miracle
April 21, 2017My derm prescribe this and after only 1 week I'm eczema free! After a lifetime of eczema, it feels amazing just to be able to not worry about being out in public. Steroids were the only thing that worked for me, but I absolutely hated using them. Still a new drug however, so I'm uncertain how the side effects compare to steroids. Just wanted to share what worked for me. Hopefully insurance will cover it, 700$ a tube is insane. Edit: I also started omega 3 pills and probiotics. The warmer weather also helped I think. I'm not sure which one helped the most, but just wanted to add exactly what I introduced to my body to help.
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eucrisa
Feb. 7, 2021I use eucrisa on my face & it’s helped ALOT. i definitely recommend it for eczema. i started using it like 2 years ago, & before i started using it my face would get SO SO SO dry and it would literally feel like leather, it felt & looked disgusting. i tried SO many products & i could never find anything that really helped. now, my skin has never been softer. the first time i used eucrisa, it burned/stinged like hell & its very uncomfortable, & people complain about it/stop using it for that reason. the burning should go away after a bit, and once you start using it often it should not burn anymore, unless you stop using it for a few days & then use it again. it also makes your skin very greasy obviously, and ive seen people stop using it for this reason as well, but what i do is i put a thick layer on before i go to sleep so that my skin absorbs it overnight & i dont have to go in public with it on. after a few uses there should be a noticeable difference. my skin hasnt been dry at all since ive started using it every night. its my holy grail n i cant see myself ever switching to anything else **edit: i know it doesnt work for everyone, but i would recommend using it for like 1-2 weeks before deciding that it doesnt work. if the burning does get worse over time then yeah i would stop using it. also my eczema hasnt really blistered since i was little so id assume that makes a difference as well
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Eucrisa burning?
Dec. 24, 2020I’m having a reaction on my face (above my eyelids and below my eyes specifically). I’ve used Elidel in the past for delicate areas but my derm recently switched me to Eucrisa, proclaiming it to be “the new Elidel”. I just applied Eucrisa to my affected areas and it BURNS. I’ve never had a topical cream cause such an intense burning sensation before- I seriously thought I had put the wrong cream on and was reacting to it. Has anybody else had a similar reaction to Eucrisa??
Is Eucrisa Right For Me?
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You are 3 months of age or older
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You have mild to moderate atopic dermatitis
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Enjoy 24/7/365 access to your dedicated care team.
Discover effective treatments with board‑certified dermatologists.
Get prescriptions for immediate relief.
Get your medications.
Design a plan for sustained relief with your personal care coordinator.
Experience less itch, reduced inflammation, better sleep, and improved wellbeing.
Enjoy 24/7/365 access to your dedicated care team.
Ensure that you have everything you need to maintain your relief.
Don't worry - your coordinator will remain available to you.
Review progress with your care team and fine-tune your plan.
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What are other patients saying?
The first night of Eucrisa was awful! She said it felt like lava on her face! I learned on this subreddit to put it in the fridge. We did that for the next morning and it was a huge difference. In two days her skin cleared up and has remained clear over the last month.
View SourceEucrisa started working within two days... The itch is still there but my skin doesn't tear off when I scratch it so Eucrisa definitely helps a lot. But it's not a cure.
View SourceI've been on it for about two weeks now, and I'm pretty happy with it! [...] I had a patch on my hand that went back to flaring after I got off the Prednisone, and the Eucrisa cleared it up!
View Source