lemma health
Ebglyss (lebrikizumab)
Available Online
Injection
Every 2-4 weeks
Copay Card Available
Available by Prescription
As Low as $5
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  • Works quickly - significant itch/sleep improvement in first week
  • 70% of patients saw >75% improvement at 16 weeks
  • Effective across different populations globally
  • Mild to moderate reactions (eye inflammation, headache, injection site reactions)
  • Less than 5% experience common side effects
“I have strong excema since my childhood with several hospitalisations, even Dupixent only helped to reduce the problem but not get rid of it. There is newer version of Dupixent …”
- Patient review
How well does Ebglyss work?
Ebglyss is above average for atopic dermatitis "Biologics" treatments.
What is the evidence behind Ebglyss?
Lebrikizumab significantly improves moderate-to-severe atopic dermatitis symptoms compared to placebo. In phase 3 trials, 58-72% of patients achieved a 75% improvement in disease severity scores after 16 weeks of treatment.
What does the research say?
Study Summary

Lebrikizumab was effective in treating moderate-to-severe eczema in two large clinical trials. After 16 weeks, about 33-43% of patients achieved clear or almost clear skin compared to 11-13% on placebo. The medication also helped reduce itch, and while it caused some eye inflammation (conjunctivitis), most side effects were mild.

Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis.
Study Type
Clinical Trial
Studied Population
Total Patients: 851
Severity: moderate to severe
Age: 12+ years (adolescents and adults)
Results
About 3 times more patients achieved clear or almost clear skin with lebrikizumab compared to placebo
Study Summary

Lebrikizumab was effective in treating moderate-to-severe eczema over 52 weeks. After initial treatment, patients maintained good results whether they received the drug every 2 weeks or every 4 weeks, with about 75-80% of patients maintaining clear or almost clear skin.

Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials.
Study Type
Clinical Trial
Studied Population
Severity: moderate to severe
Age: adolescent and adult
Results
What are other patients saying?
  • Ebglyss (game changer)
    June 7, 2024
    I have strong excema since my childhood with several hospitalisations, even Dupixent only helped to reduce the problem but not get rid of it. There is newer version of Dupixent called Ebglyss (Lebrikizumab) [came to the market on 11/2023] which is very effective. I recommend to try it, it saved me and reduced my problems about 90%!!!
  • Just took first dose of Ebglyss....feeling very hopeful
    Oct. 21, 2024
    Hello everyone, As I posted before, I failed on Dupixent every over week after about 6 months. Then switched to taking it weekly. Some relief, but still got pops regularly, so doctor switched me to Ebglyss. I took my first dose (loading dose) yesterday. I am optimistic after this one dose because I did not wake up with the tingling, low-grade itch/burn that I usually wake up to....Each dose reaches max plasma and efficacy at about 7 to 8 days so I was not expecting anything. I will keep you posted. I'm in the US and the company has a bridge program if your insurance will not cover it. My plan wanted me to try Adbry first but didn't want to go that route because that company has limited copay and other support. So if your insurance does not cover it, you can pay $25 per month as long as your doctor continues to send in periodic prior auth requests to your plan. I think this is good for 2 years. Hopefully, during that time you can get it covered if you are getting results.
  • Eye problems with Dupixent - switch to Ebglyss or Rinvoq/Cibinqo?
    Dec. 9, 2024
    I have been on Dupixent for almost a year now (started in January) and I started developing conjunctivitis around May and it's only gotten worse. I saw an eye doctor who prescribed me steroid eye drops (Lotemax) which helped control the conjunctivitis but since tapering off, eye problems are back again. I have been using them for a week then taking 2 weeks break to avoid more serious eye problems (glaucoma) but the weeks between are just so rough. My dermatologist has given me some alternatives but I'm torn on how to proceed (she also didn't give me great advice) and hoping I could get some input here. She said I could switch to Adbry or Ebglyss (biologics), or a pill like Rinvoq or Cibinqo to alleviate the eye problems. I have major needle anxiety so Adbry is not an option (loading is 4 shots and subsequent are 2 shots). I couldn't find much about Ebglyss but see it targets only IL-13 pathway, which seems to be the pathway linked to eye problems. However, my dermatologist said it's IL-4 that actually causes eye problems. Does anyone had input on eye problems with Ebglyss (what I could find is that all the eczema biologics lead to eye problems)? The alternative would be to use Rinvoq or Cibinqo and I'm a bit hesitant due to the immunosuppressive effects. I work in a lab with biohazards and unfortunately, no one really practices safe handling of biohazards so I don't know how dangerous that could be for me. That said, I found that these pills mainly increase susceptibility to airway and skin infections. I am also unsure about the increase in acne using these medications. Has anyone else made the switch from Dupixent to Ebglyss or to Rinvoq/Cibinqo and found success?
The medication helps reduce itching quickly, with some patients experiencing improvement as early as 2 days after starting treatment. It also helps improve sleep disruption caused by itch.
What does the research say?
Study Summary

Lebrikizumab, a medication that targets IL-13, significantly improved moderate-to-severe atopic dermatitis symptoms in adults. After 16 weeks, about 60% of patients taking lebrikizumab had clear or almost clear skin compared to 16% taking placebo.

Lebrikizumab improved itch and reduced the extent of itch interference on sleep in patients with moderate-to-severe atopic dermatitis: two randomized, placebo-controlled, phase III trials.
Study Type
Clinical Trial
Studied Population
Total Patients: 751
Severity: moderate to severe
Age: 18+
Results
Significantly more patients achieved 75% improvement in eczema symptoms with lebrikizumab
Study Summary

Lebrikizumab helped improve itching and sleep quality in patients with moderate-to-severe eczema. Patients who experienced less itching and better sleep also reported better quality of life after 16 weeks of treatment.

Lebrikizumab monotherapy impacts on quality of life scores through improved itch and sleep interference in two Phase 3 trials.
Study Type
Clinical Trial
Studied Population
Severity: moderate to severe
Age: 16+
Results
Patients who responded to treatment with improved itch and sleep showed significant improvements in quality of life measures
What are other patients saying?
  • Great results so far with Ebglyss
    Oct. 31, 2024
    Hello again, As I mentioned in previous posts, Dupixent stopped working for me and I started Ebglyss. Took first dose on Sunday, October 20th and my overall burn/itch level has decreased DRAMATICALLY. Also, no new flare ups. I feel the way I felt before eczema took over last summer. I hope it continues to work. So thankful for the relief.
  • Lebrikizumab/Ebglyss
    July 15, 2024
    Saw my derm today and he told me this was approved for eczema in the US last week (I think that’s the one he was talking about). I see some older posts on here specifically about clinical trials so I’m curious about anyone’s experiences on this med especially if they’ve been on it a while with the trials. For context, I’m on 30 mg Rinvoq. I’m stable ish now (compared to the past) but still have more eczema than I should at this point. First two years on 15 mg were AMAZING though. I got one dose of Dupixant before rinvoq and developed severe head neck derm. The derm said it’s still a risk with this new med but not as prevalent. So it may be something to look into for me down the line and would love peoples experiences and insights. TIA!
Lebrikizumab has a favorable safety profile with most side effects being mild to moderate. The most common side effects include conjunctivitis (eye inflammation), injection site reactions, and upper respiratory infections. Serious side effects are rare.
What does the research say?
Study Summary

This analysis looked at the safety of lebrikizumab across eight clinical trials in patients with moderate-to-severe eczema. The medication was generally safe, with most side effects being mild or moderate. The most common side effect specific to lebrikizumab was conjunctivitis (eye inflammation), occurring in about 8.5% of patients.

Safety of Lebrikizumab in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: An Integrated Analysis of Eight Clinical Trials
Study Type
Randomized Controlled Trial
Studied Population
Total Patients: 1,720
Severity: moderate to severe
Age: adolescents and adults
Results
Study Summary

Lebrikizumab was found to be generally safe for treating moderate-to-severe atopic dermatitis in adults and adolescents. The most common side effect was conjunctivitis (eye inflammation), occurring in 8.5% of treated patients compared to 2.5% in placebo. Most side effects were mild or moderate.

373 Safety of lebrikizumab in adults and adolescents with moderate-to-severe atopic dermatitis: data from eight trials
Study Type
JournalArticle
Studied Population
Total Patients: 1,720
Severity: moderate to severe
Age: adults and adolescents
Results
What are other patients saying?
  • Ebglyss (game changer)
    June 7, 2024
    I have strong excema since my childhood with several hospitalisations, even Dupixent only helped to reduce the problem but not get rid of it. There is newer version of Dupixent called Ebglyss (Lebrikizumab) [came to the market on 11/2023] which is very effective. I recommend to try it, it saved me and reduced my problems about 90%!!!
  • lebrikizumab
    Feb. 1, 2024
    does anyone know when this drug is supposed to come out? very eager for it to be released, especially given i failed dupixent. currently on cibinqo but i don't want to be on it long term. was considering adbry, but from what i've read it's not very effective.
  • ECZEMA AND STAPH , options i’ve been given please help
    July 17, 2024
    HELLO FROM THE UK 21 YEARS OLD i’ve been suffering with eczema and recently i’ve had to be hospitalised with staph infection , its been cleared from my bloodstream but the staph seems to not stop growing on my face and infecting my face, my eczema is controlled and well but the staph seems to be making my face worse and eczema worse , just been to my NHS dermatology appointment and they’ve given me 3 options , they’ve said it’s to supress my immune system and eliminate the staph option 1- phototherapy (sunlight uv rays) this option seems to be the last option to pick for myself , i have to visit the hospital 3 times a week for this therapy and also risks the chance of skin cancer etc option 2- methotrexate , they’ve given me this option to supress my immune system and hopefully treat my eczema option 3- They’ve given me a option to go on a trial to a new drug that is not on the market yet called lebrikizumab , it’s an injection i have to take once a month and im not exactly sure how it’s going to help or work but that’s why ill be on a trial for it, read the side effects and there’s also a risk of cancer whilst taking this drug. I need help into choosing what would be the best safest option , i know everyone’s body is different and reacts differently but some help would be appreciated , if anyone has had any experiences with any of the options please let me know i just want the staph to go and i don’t mind having to deal with the eczema on its own , it’s just the staph that keeps appearing on my face that’s making it worse i’ve also tried taking probiotics for it , does not work , and normal supplements and vitamins like oregano , ginger , fish oils etc , i seem to believe it’s helping my eczema be controlled but not the staph Also the reason why it’s probably so hard for the staph to go is because my immune system is fucked from the amount of antibiotics i’ve been taking for the past 6 months Any help would be appreciated, thank you
The medication can be given either every 2 weeks or every 4 weeks after initial loading doses, with both dosing schedules showing effectiveness. This flexibility in dosing may be beneficial for patients.
What does the research say?
Study Summary

Lebrikizumab was effective in treating moderate-to-severe eczema over 52 weeks. After initial treatment, patients maintained good results whether they received the drug every 2 weeks or every 4 weeks, with about 75-80% of patients maintaining clear or almost clear skin.

Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials.
Study Type
Clinical Trial
Studied Population
Severity: moderate to severe
Age: adolescent and adult
Results
Study Summary

Lebrikizumab helped maintain clear or almost clear skin in patients with moderate-to-severe eczema for up to 2 years. About half of the patients achieved completely clear skin, and more than 55% reported having no or minimal itching after 2 years of treatment.

708 - Raising the bar of efficacy in atopic dermatitis: lebrikizumab maintains depth of response over 2 years
Study Type
JournalArticle
Studied Population
Severity: moderate-to-severe
Age: not available
Results
About half of patients maintained completely clear skin
What are other patients saying?
  • Great results so far with Ebglyss
    Oct. 31, 2024
    Hello again,As I mentioned in previous posts, Dupixent stopped working for me and I started Ebglyss. Took first dose on Sunday, October 20th and my overall burn/itch level has decreased DRAMATICALLY. Also, no new flare ups. I feel the way I felt before eczema took over last summer. I hope it continues to work. So thankful for the relief.
  • Side Effects on Dupixent / Ebglyss
    Nov. 22, 2024
    Hi, I've had chronic severe eczema all my life for over 20 years, and recently got put on Ebglyss. I was trying to get on Dupixent initially, but the dermatologist suggested me to get ebglyss instead, as one of the most common side effects of dupixent is eye flare-ups, and my eyes area was already pretty considerably bad. I got my first dose (2 injections) a few days ago. I was okay for a while but then I suddenly started getting these moments of extremely intense dizziness now and then. Like maybe once every two hours. It gets really dizzy for about 1~2minutes and it is very similar to how it feels like when being drunk/intoxicated. I feel like losing balance, getting some sort of a 'high'. If it happens when I'm standing, I need to stop and wait it out until it goes away. I've been getting those short moments of strong dizziness, and now today (day4 since injection), the dizziness is lingering for much longer. I feel nauseous and losing balance. On their side effects list, dizziness and lightheadedness is noted but I just don't know if it is okay for me to feel this sort of intense dizziness. Is there anybody who experienced a similar dizziness situation? I am not certain if it is okay to wait it out, tolerate it, or if I should seek medical attention. I'm not even sure if they have anything they can do for me regarding the dizziness. Would be so great if I could hear other people's side effect experiences while being on dupixent/ebglyss, and if there is a way to handle it better. Thank you!
Is Ebglyss Right For Me?
What is Ebglyss?
Lebrikizumab (EBGLYSS) is a prescription medicine given as an injection under the skin that works by targeting a specific protein in your immune system that contributes to atopic dermatitis.
What are the requirements for taking Ebglyss?
Ebglyss might be right for you if:

  • You are 12 years or older

  • You weigh at least 40 kg (88 pounds)

  • You have moderate-to-severe atopic dermatitis

  • Topical prescription treatments don't work well enough for you or aren't recommended for you

How does Ebglyss work?
Lebrikizumab works by blocking a protein called interleukin-13 (IL-13), which plays an important role in causing inflammation in atopic dermatitis. By blocking IL-13, it helps reduce inflammation and symptoms of the disease.
Is it safe for children?
Lebrikizumab is safe and effective for children 12 years and older who weigh at least 40 kg (88 pounds). It has not been tested in children younger than 12 years or in those who weigh less than 40 kg.
Is it safe for elderly patients?
While lebrikizumab has been used in patients 65 years and older, not enough older adults were included in clinical studies to determine if they respond differently from younger adults.
Is it safe during pregnancy?
There isn't enough information to know if lebrikizumab is safe during pregnancy. Animal studies haven't shown harmful effects, but you should discuss the risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.
Is it safe during breastfeeding?
It's not known if lebrikizumab passes into breast milk or what effects it might have on a breastfed baby. You should discuss the benefits of breastfeeding and potential risks with your healthcare provider.