lemma health
Cibinqo (abrocitinib)
Available Online
Oral
Once daily
Copay Card Available
Available by Prescription
As Low as $0
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  • Rapid itch relief within 24 hours
  • 61% of patients see >75% improvement at 12 weeks (200mg dose)
  • Long-term effectiveness in preventing flares
  • Common mild effects include nausea (14%), headache (8%)
  • May cause temporary decrease in blood platelet counts
“Please read. I have had eczema for 20+ years and just came out of an incredibly difficult flareup with periods of suicidal ideation. Partway through this flareup I was on …”
- Patient review
“So I just read on the daily news that pops out on my phone, apparently cibinqo by Pfizer has been approved by the U.S,anyone gonna give it a try...my eczema. …”
- Patient review
“I’ve had eczema since I was little and went through all of the corticosteroid creams we’ve all been through, but I’ve always had pretty bad eczema on my hands. Given …”
- Patient review
How well does Cibinqo work?
Cibinqo is above average for atopic dermatitis "JAK Inhibitors" treatments.
What is the evidence behind Cibinqo?
Abrocitinib is effective at treating moderate-to-severe eczema, with higher doses (200mg) showing better results than lower doses (100mg). After 12 weeks of treatment, 61% of patients on 200mg and 45% on 100mg saw at least 75% improvement in their eczema symptoms, compared to only 10% on placebo.
What does the research say?
What are other patients saying?
  • Why do so few of you use Jak inhibitors?
    March 26, 2024
    I only in the last few weeks reentered the world of eczema after I finished up on a trial of Cibinqo (5 years - was amazing!). I was very lucky that even though my eczema flared back up very quickly I was immediately approved for Rinvoq which worked within days. I'm in Australia so required PBS approval. Eczema gone regain within days. Anyway - it's been so long since I've looked through these forums because I've had no real reason to, but I'm genuinely surprised at the amount of people (or lack there of) who use or discuss the above Jak inhibitors. I thought it would be more wide spread by now. Dupixent gets brought up a lot but little mention of these. So out of curiosity I was wondering why? Is it that you haven't heard of them? Haven't got the point yet where you'd try them? Dermatologist hasn't given the option? Hard to get in your country? Side effects make you apprehensive? Zero judgement on this one - genuinely just interested why you think these aren't more wide spread. **UPDATE** Thanks so much - so many interesting replies. I really didn't realise the cost/insurance issues in the US were so prohibitive so so many people getting access to this - and there are obvious concerns about side effects. I'd really encourage if you love a deep dive, this presentation from someone who ran multiple medical trials is pretty fascinating and does a great job of explaining what a Jak inhibitor actually does and is at least partially reassuring on some of the side effects (but yes - there are still some potential side effects.) [https://www.youtube.com/watch?v=Lec7D5MXkYg](https://www.youtube.com/watch?v=Lec7D5MXkYg) I've had amazing results, zero side effects etc and been on one for 5 years. I'm more than happy to take a pill a day for the rest of my life if it means quality of life but I realise not everyone wants to do that - and some people will experience side effects. Good luck to you all on your journey!
  • THOUGHTS ON CIBINQO
    Sept. 28, 2023
    I have had eczema my entire life and I'm 56 yoa. In December of 2022, I had the worst flare up of my entire life. The eczema covered my entire body. It was horrible. My life changed drastically. I thought it would heal on its own but I had to seek medical treatment in April 2023. I started with the vitamins and supplements but this offered little relief. I went to work and that's pretty much it. I stopped going to the gym which is something that I had done for the last 30 years. I lost about 20 pounds. I tried the cool baths. I had an allergy test and found all known allergens. Anyway, I visited the dermatologist in July and he prescribed Ciginqo. He did a biopsy only to tell me what I already knew...that I had atopic dermatitis. I started the meds about 5 weeks ago. Not sure if it's making much of a difference. It's very expensive. My blood pressure and cholesterol were elevated and that scared me. So right now I stopped taking it ..... Anyone use/ used this? Your thoughts positive or negative? Thank you.
  • Cibinqo? And Pfizer Reimbursement
    May 4, 2024
    My dermatologist prescribed cibinqo for my eczema. I’ve already tried dupixent, rinvoq, and adtralza in that order within the past 5 years. I’m in Ontario, Canada. Dupixent’s patient support program (psp) bridged the cost of the drug once my private insurance ran out. Rinvoq’s psp also bridged. And adtralza’s psp provided the drug for 18 months (my insurance wouldn’t cover this one). Cibinqo’s PfizerFlex program is one of the most frustrating programs I’ve dealt with. I feel like I was on the other medications within 1 month of the initial prescription and this is going to take forever to get on cibinqo. My private insurance will max at $1000. So Pfizer wants me to apply for Trillium. I have a high deductible because I still live with my parents(22 and doing my master’s rn). PfizerFlex initially told me they won’t cover my deductible then I started getting pushy because I’m not going to go through all this just to not being able to afford it. Then they said they can. I’m really frustrated with the lack of transparency and I feel like my caseworker doesn’t listen to me. I ask him if there’s paperwork and he’s like just tell me how much all ur loans are. This isn’t my first rodeo. Idk how is cibinqo for others? Working for eczema? Any experience with PfizerFlex psp? Thank you :)
The medication can provide rapid relief from itch - patients noticed improvement within 24 hours of starting treatment. This quick relief from itching led to significant improvements in quality of life for patients.
What does the research say?
What are other patients saying?
  • Abrocitnib/cibinqo
    Sept. 15, 2024
    Hello all, Dermatologist has prescribed Abrocitnib for severe atopic dermatitis and I wanted to check in before I make the very expensive purchase. Is anyone here using this to help with their dermatitis? Have you found relief? Is it safe to use? What are the short term/long term side effects? How long must one be on it? The doc had prescribed it for 6 months at least but will the flare ups come back after it is stopped? Should it be taken lifelong? Thank you for any help 🙏🏼
  • How long until Dupixent starts working?
    March 15, 2024
    I have severe eczema, the itching is so intense that I scratch until I bleed and I can't sleep at night. I have had two biopsies done both confirming it was eczema. I was previously on rinvoq and cibinqo both not working for me. So, 13 weeks ago I started Dupixent 300mg and I guess it is working some. I would say my condition before starting Dupixent was 1/10(worse) and now I'm probably a 4/10. Is this the best I am going to get on Dupixent at this point or should I wait it out and see if it gets better? I just want my life back and not have to go on prednisone every two weeks. I have been to three different doctors over the past two years and to urgent care 10+ times. Please give me suggestions.
  • Alternatives to Dupixent? Desperately want to help my partner with severe eczema.
    Feb. 23, 2024
    He’s devastatingly disappointed- he was put on Dupixent and told by every doctor and nurse it would be the life changing cure for him. And it was - for a short time. The eczema cleared and his skin was healthy for the first time in his adult life! But very quickly he started getting facial flare ups and eye problems that were so severe he couldn’t function. So now we’re back to square one. The Dupixent is leaving his system and the eczema is back. We’re doing all the small things - constant cleaning, oatmeal baths, infrared sauna, etc. but I know it won’t be enough. My heart just breaks for him because for about a week and a half he was so confident and happy with how he was feeling and looking. He tried cibinqo a while back and doesn’t remember it being as effective as Dupixent, and is also apprehensive about being on an immunosuppressant. Open to any suggestions here, anecdotal or otherwise!
The medication is generally well-tolerated, with most side effects being mild. The most common side effects include nausea (14% with 200mg dose), headache (8%), and upper respiratory infections. Some patients experienced temporary decreases in blood platelet counts, which typically stabilized with continued treatment.
What does the research say?
What are other patients saying?
  • Anyone feedback on Cibinqo?
    Feb. 11, 2022
    Just trying to get a feel if anyone with severe atopic dermatitis or eczema has tried the new JAK1 inhibitor oral drug Cibinqo from Pfizer? I want to know if I should do it or stick with Dupixent?
  • After a wild 4 year flareup, I am finally clear and medicine-free
    Dec. 9, 2023
    Please read. I have had eczema for 20+ years and just came out of an incredibly difficult flareup with periods of suicidal ideation. Partway through this flareup I was on dupixent for some time but had to quit because I was losing my eyesight. The thing that finally allowed my skin to heal up was a sample bottle of Cibinqo. This allowed my immune system a chance to calm down, and finally I am able to be off of everything. No topical steroids, no protopic, no JAKs, no MABs, etc. I just have a skin regiment centered around skin healing and nourishing. **DO NOT MOISTURIZE IMMEDIATELY AFTER WASHING. TREAT IT LIKE A WOUND.** After you wash your skin (shower, or cleaning a very itchy area) do NOT moisturize right away. I learned this the hard way. Twice actually. I had gained this knowledge through tons of experimentation with my skin about 3 years ago, but somehow forgot it through all the chaos of life and after dozens of other treatment experiments. I rediscovered this recently while reading again about wound treatment. When you understand [how creams can prevent wound healing](https://www.bbc.com/news/health-44600618), and then you understand why you have a part that is **incredibly itchy every single day** whereas other parts of your body are not is [because of staph bacteria](https://www.nature.com/articles/d41586-023-03561-x), you then realize you should treat the parts that you were scratching \*as if they are a wound\*. Proper wound treatment means: washing very lightly with light soap and warm then let it dry. Do not apply anything to it. **No creams, no steroids** for some time. First allow your body to build its own natural thin barrier (10-45 minutes), and then you can carefully and lightly add your creams/steroids/etc. Read [that article above which also explains how wounds heal](https://www.bbc.com/news/health-44600618) to internalize to yourself why you are doing this. Whether it will take 10 minutes or 45 minutes for this barrier to form really depends on how badly you've damaged your skin with scratching. **Treat your eczema skin like a model treats their face** That is, very gently and with moisturizing products that are incredibly nourishing, repairing, and safe for sensitive skin. I am now using many products which are meant for the face (where the most sensitive skin is) on the parts of my body where I scratched. This is what I apply, in order (after each layer, allow 5-10m to absorb before going to the next layer): \- A vitamin C serum (Dermadoctor Vitamin C at night, Vanicream Vitamin C serum in the morning) \- Peptides (Inkey List Peptide Moisturizer) \- Niacinamide (aka Nicotinamide) at night (CeraVe Skin Renewing Night Cream) \- General moisturizer with humectants (Bioderma Atoderm) \- Calming moisturizer (XeraCalm Lipid Replenishing Balm) I still get the itch sometimes at night, but my skin heals quite a bit even just over 12 hours now. I feel like I get 5 days worth of healing now in 12 hours. For more details about how this stuff works I suggest reading Skincare Core in r/SkincareAddiction and the materials in r/DIYBeauty as well. But please please remember not to use any products after washing your skin for at least 10-45 minutes (depending on how badly you've damaged it). I really hope this helps some people. PS: For any area I scratch, I grab a small piece of paper towel and spray a copious amount of hypochlorous acid on it, then gently wipe the area I scratched. I'm trying to avoid the bacteria growth explained in the article above.
  • medication recommendation!
    May 5, 2024
    Hi everyone! I just wanted to come on here and say that Dupixent and Rinvoq are not the only options for long term meds, even though those are the only ones i've really seen discussed on here. there are two newer drugs on the market that I would like to recommend to anyone who's failed Rinvoq and Dupixent, as I have. They are Cibinqo and Adbry. I was in the trial for Cibinqo before it was on the market and it worked super well for a while, but after a while it stopped (however that's how my body works, i've failed 5 eczema meds LOL! it truly was a miracle drug for a while and i've seen lots of positive experiences with it). Cibinqo is also pills, not an injection! I still recommend it for anyone who's failed Dupixent or Rinvoq, especially if you're afraid of needles. Adbry is what i'm currently on and it is working wonders. It is an injection (every two weeks) and it takes 1-2 months to build in your system, but now my skin is AMAZING! my water barrier has completely healed and I can move without pain now. I can't remember the last time I could fully straighten my arms without my skin feeling like it would rip open. I'm making this post to let everyone know that if you fail Dupixent or Rinvoq there is still options!!! If anyone has any questions I can do my best to answer them too.
For patients who respond well to initial treatment, continuing the medication helps prevent flare-ups. In a long-term study, only 19% of patients on 200mg experienced a flare-up compared to 81% of those who stopped treatment. If flares occur, restarting treatment is effective at regaining control of symptoms.
What does the research say?
What are other patients saying?
  • Any advice on Cibinqo and naturally healing severe atopic dermatitis?
    Nov. 6, 2024
    Hi there! For context, I've (23F) been struggling with severe atopic dermatitis pretty much my whole life with some pauses due to medications I've taken or random changes my body has had. During the last 2 years i was on a trial for lebrikizumab which was going pretty okay, and for the last ≈10 months I've been medication free. During the summer i noticed i was flaring up again and was hoping to "heal my eczema naturally" as some people put it, but the result is just the worst flare I've had in 5 years. It's on my entire torso, back, arms, face and it's starting to spread to my legs, I just hate it. My dermatologist is about to put me on antibiotics and Cibinqo, as my skin is pretty red and infected and I'm kinda scared, as i really hoped to "fix" myself naturally. Does anyone have any advice or opinions on Cibinqo? Also, can someone share their experience with naturally healing severe eczema? I'm trying my best to stay off sugar, gluten, processed foods, etc., but so far it doesn't seem to do anything. I tried to heal my gut and eat better, as i suspected my digestion had to do with my state, but nothing much has come out of it. I've been following Michelle Mills (eczema coach) on YouTube and trying to find my triggers, but so far I've just crossed some foods off of my list and that's it. I'll be really greatful for any advice!
  • Experience with Cibinqo?
    Aug. 20, 2024
    Long time lurker on this sub, but have never posted. Without getting too in depth, I’ve suffered from eczema from my scalp to the undersides of my feet for my entire life. It’s effected my quality of life greatly (physical pain, mental health etc) up until about 3 months ago. I’ve started on 200mg of Cibinqo and it quite literally changed my life in less than a week, incredibly grateful for that. Unfortunately this medication has been hitting me with some, well, shitty side effects. Just curious if any of you are familiar with the drug, and how you deal with the drowsiness, headaches, nausea and the acne? Don’t get me wrong, I would rather live with these side effects then with the brutal eczema, but do these go away over time? How do you deal with these things? TIA!
  • Dupixent no longer working, what next? I want to give up.
    March 14, 2024
    I’ve been on Dupxient just over a year, it was a miracle drug and cleared my skin for about 6 months and ever since that point it’s got less and less effective. Now at the 12 month point and it’s stopped working completely and I’m in a fully body flare but with eczema now on areas I never had it before (hands face and neck). This could well be TSW too, but either way it’s fucking horrendous and I can’t live without some kind of drug to assist me. So, what next? I’ve been on methotrexate before Dupxient which did nothing for me and was on Azithiaprine in my childhoods for a seperate issue, auto immune entrothopy. I have no idea what to to do or what treatment to choose next but I need some sort of quick relief but I’m so worried about the all the potential side effects of the options (Rinvoq, Cibinqo, Cyclosporine.) Has anyone been in a similar situation and can provide their thoughts/advice? I know I cannot live like this.
Is Cibinqo Right For Me?
What is Cibinqo?
Abrocitinib (CIBINQO) is a JAK inhibitor medication that works by blocking specific enzymes involved in inflammation.
What are the requirements for taking Cibinqo?
Cibinqo might be right for you if:

  • You are 12 years or older

  • You have moderate-to-severe atopic dermatitis

  • Other systemic treatments (including biologics) haven't worked well enough for you

  • You cannot use other systemic treatments

How does Cibinqo work?
It works by blocking an enzyme called JAK1 (Janus kinase 1), which helps reduce inflammation in the body. This helps control the symptoms of atopic dermatitis.
Is it safe for children?
Safe and effective for patients 12 years and older weighing at least 25 kg (55 lbs). Not approved for use in children under 12 years old.
Is it safe for elderly patients?
Can be used in elderly patients but with caution. Older adults (65+ years) had higher rates of side effects and discontinuation in clinical trials. They may be at higher risk for infections (especially shingles), low blood cell counts, and low platelet counts.
Is it safe during pregnancy?
There is not enough data to determine if abrocitinib is safe during pregnancy. Animal studies showed some adverse effects at high doses. All pregnancies should be reported to the pregnancy registry. Discuss risks and benefits with your healthcare provider.
Is it safe during breastfeeding?
Breastfeeding is not recommended during treatment with abrocitinib and for one day after the last dose due to potential serious risks to the infant.