Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial

• Results Overview

  Upadacitinib (an oral medication) combined with topical steroids was significantly more effective than placebo plus topical steroids in treating moderate-to-severe eczema, with 65-77% of patients showing major improvement compared to 26% on placebo.

• Study Summary

  Num Participants:

  901

  Study Type:

  Rct

  Control Group:

  Placebo Plus Topical Corticosteroids

  Efficacy End Points Treatment:

  {'EASI-75': 65, 'vIGA-AD': 40}

  Efficacy End Points Control:

  {'EASI-75': 26, 'vIGA-AD': 11}

  Side Effects Treatment:

  Adverse Event	Severity	Percentage Affected
  Acne	Low	10.0
  Nasopharyngitis	Low	5.0
  Upper Respiratory Tract Infection	Low	5.0

  Side Effects Control:

  Adverse Event	Severity	Percentage Affected
  Acne	Low	2.0