Adding dupilumab injections to nasal steroid spray significantly reduced nasal polyps and improved sense of smell compared to using nasal steroid spray alone in patients with chronic sinusitis.
Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.
Adding dupilumab injections to nasal steroid spray significantly reduced nasal polyps and improved sense of smell compared to using nasal steroid spray alone in patients with chronic sinusitis.
Num Participants:
51
Study Type:
Rct
Control Group:
Placebo Plus Mometasone Furoate Nasal Spray
Efficacy End Points Treatment:
{'Nasal polyp score change': -1.9, 'Lund-Mackay CT score difference': -8.8, 'SinoNasal Outcome Test difference': -18.1, 'UPSIT score difference': 14.8}
Efficacy End Points Control:
{'Nasal polyp score change': -0.3}
Side Effects Treatment:
Adverse Event | Severity | Percentage Affected |
---|---|---|
Nasopharyngitis | Low | 47.0 |
Injection Site Reactions | Low | 40.0 |
Headache | Low | 20.0 |
Side Effects Control:
Adverse Event | Severity | Percentage Affected |
---|---|---|
Nasopharyngitis | Low | 33.0 |
Injection Site Reactions | Low | 7.0 |
Headache | Low | 17.0 |
Author(s)
TBD
Publication Date
2024-01-01 00:00:00
Publication Source
None
Citation Count
656
Related Datasets