1. Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.


  • Results Overview

    Adding dupilumab injections to nasal steroid spray significantly reduced nasal polyps and improved sense of smell compared to using nasal steroid spray alone in patients with chronic sinusitis.

  • Study Summary

    Num Participants:

    51

    Study Type:

    Rct

    Control Group:

    Placebo Plus Mometasone Furoate Nasal Spray

    Efficacy End Points Treatment:

    {'Nasal polyp score change': -1.9, 'Lund-Mackay CT score difference': -8.8, 'SinoNasal Outcome Test difference': -18.1, 'UPSIT score difference': 14.8}

    Efficacy End Points Control:

    {'Nasal polyp score change': -0.3}

    Side Effects Treatment:

    Adverse Event Severity Percentage Affected
    Nasopharyngitis Low 47.0
    Injection Site Reactions Low 40.0
    Headache Low 20.0

    Side Effects Control:

    Adverse Event Severity Percentage Affected
    Nasopharyngitis Low 33.0
    Injection Site Reactions Low 7.0
    Headache Low 17.0

Study Information

Original Paper

Author(s)

TBD

Publication Date

2024-01-01 00:00:00

Publication Source

None

Citation Count

656

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